Department: Pharmaceutical Science and Research (School of Pharmacy)
Office: BBSC 241-N | Laboratories: BBSC 241R and CEB 108A
Phone: (304) 696-2708 | Fax: (304) 696-7136
I have a broad and long-standing interest in the field of chronic disease and muscle biology. Previous work in my laboratory has centered on examining the effects of aging and disease on striated (skeletal and cardiac) and smooth muscle structure and function. Human, rodent and cell culture models are commonly employed. Recently we have expanded upon these efforts and have begun to examine how nanotechnology can be used to improve disease diagnosis and detection.
The outcomes of this work have resulted in the formation of the Center for Diagnositc Nanosystems. The Center for Diagnostic Nanosystems is focused on developing novel molecular based diagnostic tests that can be used by individuals and public health systems to facilitate personalized medicine. This center is divided into three divisions: 1.) Basic Science Division, 2.) Translational Medicine Division and 3.) Nanomedicine Division. Each division is headed by a senior scientist. There are currently fifteen projects under investigation some of which include the following: (i.) Development of nanowire sensors for the detection of circulating and / or exhaled miRNA. (ii.) Effect of disease on miRNA expression, (iii.) Investigation of nanoparticles for the treatment of lung disorders, (iv.) Investigation of nanoparticles for the treatment of cardiac dysfunction, (v.-x.) Molecular mechanisms associated with insulin resistance, cardiac hypertrophy, muscle atrophy, cancer cachaxia, endothelial dysfunction, and the role of reactive oxygen species in disease (several subprojects). Other work includes the investigation of nanoparticle toxicity and the development of novel bionanomotor platforms.
The following have been selected from 50 peer-reviewed publications.
Diminished muscle growth in the obese Zucker rat following overload is associated with hyperphosphorylation of AMPK and dsRNA-dependent protein kinase. Katta A, Kakarla SK, Manne ND, Wu M, Kundla S, Kolli M, Nalabotu SK, Blough ER. J Appl Physiol. 2012 May 31.
Chronic paracetamol treatment influences indices of reactive oxygen species accumulation in the aging Fischer 344 X Brown Norway rat aorta.Rice KM, Meduru S, Kakarla SK, Katta A, Mupparaju SP, Kidd B, Goebel LJ, Blough ER. Ann Clin Lab Sci. 2012 Spring;42(2):152-61.
Regulation of iron-related molecules in the rat hippocampus: sex- and age-associated differences. Thulluri S, Wu M, Blough ER, Manne ND, Litchfield AB, Wang B. Ann Clin Lab Sci. 2012 Spring;42(2):145-51.
Acetaminophen: beyond pain and Fever-relieving. Blough ER, Wu M. Front Pharmacol. 2011;2:72. Epub 2011 Nov 9.
Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats. Nalabotu SK, Kolli MB, Triest WE, Ma JY, Manne ND, Katta A, Addagarla HS, Rice KM, Blough ER. Int J Nanomedicine. 2011;6:2327-35. Epub 2011 Oct 14.
Submicron bioactive glass tubes for bone tissue engineering. Xie J, Blough ER, Wang CH. Acta Biomater. 2012 Feb;8(2):811-9. Epub 2011 Sep 10.
Long-term efficacy of deferasirox in preventing cardiovascular complications in the iron-overloaded gerbil. Al-Rousan RM, Manzoor K, Paturi S, Arvapalli RK, Laurino JP, Darnon L, Walker EM, Blough ER. J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):117-25. Epub 2011 May 18.
Transport of single cells using an actin bundle-myosin bionanomotor transport system. Takatsuki H, Tanaka H, Rice KM, Kolli MB, Nalabotu SK, Kohama K, Famouri P, Blough ER. Nanotechnology. 2011 Jun 17;22(24):245101. Epub 2011 Apr 20.
Deferasirox protects against iron-induced hepatic injury in Mongolian gerbil. Al-Rousan RM, Rice KM, Katta A, Laurino J, Walker EM, Wu M, Triest WE, Blough ER. Transl Res. 2011 Jun;157(6):368-77. Epub 2011 Jan 13.
Akt/protein kinase B in skeletal muscle physiology and pathology. Wu M, Falasca M, Blough ER. J Cell Physiol. 2011 Jan;226(1):29-36. Review.
Effect of aging on cellular mechanotransduction. Wu M, Fannin J, Rice KM, Wang B, Blough ER. Ageing Res Rev. 2011 Jan;10(1):1-15. Epub 2009 Nov 20. Review.
Iron-induced cardiac damage: role of apoptosis and deferasirox intervention. Wang Y, Wu M, Al-Rousan R, Liu H, Fannin J, Paturi S, Arvapalli RK, Katta A, Kakarla SK, Rice KM, Triest WE, Blough ER. J Pharmacol Exp Ther. 2011 Jan;336(1):56-63. Epub 2010 Oct 14.
Impaired overload-induced hypertrophy is associated with diminished mTOR signaling in insulin-resistant skeletal muscle of the obese Zucker rat. Katta A, Kundla S, Kakarla SK, Wu M, Fannin J, Paturi S, Liu H, Addagarla HS, Blough ER. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1666-75. Epub 2010 Oct 6.
Acetaminophen improves protein translational signaling in aged skeletal muscle. Wu M, Liu H, Fannin J, Katta A, Wang Y, Arvapalli RK, Paturi S, Karkala SK, Rice KM, Blough ER. Rejuvenation Res. 2010 Oct;13(5):571-9. Epub 2010 Sep 6.
Important roles of Akt/PKB signaling in the aging process. Wu M, Wang B, Fei J, Santanam N, Blough ER. Front Biosci (Schol Ed). 2010 Jun 1;2:1169-88. Review.
Deferasirox decreases age-associated iron accumulation in the aging F344XBN rat heart and liver. Arvapalli RK, Paturi S, Laurino JP, Katta A, Kakarla SK, Gadde MK, Wu M, Rice KM, Walker EM, Wehner P, Blough ER. Cardiovasc Toxicol. 2010 Jun;10(2):108-16.
Application of poly(amidoamine) dendrimers for use in bionanomotor systems. Kolli MB, Day BS, Takatsuki H, Nalabotu SK, Rice KM, Kohama K, Gadde MK, Kakarla SK, Katta A, Blough ER. Langmuir. 2010 May 4;26(9):6079-82.
The role of DHEA in relation to problem solving and academic performance. Wemm S, Koone T, Blough ER, Mewaldt S, Bardi M. Biol Psychol. 2010 Sep;85(1):53-61. Epub 2010 May 26.
Chronic acetaminophen attenuates age-associated increases in cardiac ROS and apoptosis in the Fischer Brown Norway rat. Kakarla SK, Fannin JC, Keshavarzian S, Katta A, Paturi S, Nalabotu SK, Wu M, Rice KM, Manzoor K, Walker EM Jr, Blough ER. Basic Res Cardiol. 2010 Jul;105(4):535-44. Epub 2010 Apr 21.
Shear stress activates Akt during vascular smooth muscle cell reorientation. Rice KM, Kakarla SK, Mupparaju SP, Paturi S, Katta A, Wu M, Harris RT, Blough ER. Biotechnol Appl Biochem. 2010 Feb 18;55(2):85-90.
Utilization of myosin and actin bundles for the transport of molecular cargo. Takatsuki H, Rice KM, Asano S, Day BS, Hino M, Oiwa K, Ishikawa R, Hiratsuka Y, Uyeda TQ, Kohama K, Blough ER. Small. 2010 Feb 5;6(3):452-7.
Possible molecular mechanisms underlying age-related cardiomyocyte apoptosis in the F344XBN rat heart. Kakarla SK, Rice KM, Katta A, Paturi S, Wu M, Kolli M, Keshavarzian S, Manzoor K, Wehner PS, Blough ER. J Gerontol A Biol Sci Med Sci. 2010 Feb;65(2):147-55. Epub 2010 Jan 7.
Fluprostenol-induced MAPK signaling is independent of aging in Fischer 344/NNiaHSd x Brown Norway/BiNia rat aorta. Rice KM, Walker EM, Kakarla SK, Paturi S, Wu M, Narula S, Blough ER. Ann Clin Lab Sci. 2010 Winter;40(1):26-31.
Impaired overload-induced hypertrophy in obese Zucker rat slow-twitch skeletal muscle. Paturi S, Gutta AK, Kakarla SK, Katta A, Arnold EC, Wu M, Rice KM, Blough ER. J Appl Physiol. 2010 Jan;108(1):7-13. Epub 2009 Sep 24.
Miaozong Wu, Ph.D.
Cuifen Wang, Ph.D. – Visiting Scientist
Selvaraj Vellaisamy, Ph.D. – Postdoctoral Researcher
Prasanna “Nandini” Manne – Ph.D. Student
Steven Rogers – Ph.D. Student
Erin Fankhanel – Undergraduate Student
Srinivasa Roa Thulluri – Research Technician
Ravi Arvapalli – Research Technician
Sravanthi Bodapati – Research Technician