Professor and Chair
Department: Pharmacology, Physiology and Toxicology
Research Clusters: Office: BBSC 435-F | Laboratory: BBSC 405
Phone: (304) 696-7319
- Succinimide-induced nephrotoxicity: The succinimide ring is incorporated into hundreds of chemicals used as drugs, agricultural fungicides, and industrial agents. Toxicity to the kidney (nephrotoxicity) has been associated with exposure to succinimide antiepileptic agents and some agricultural fungicides. Recent work has determined that succinimide metabolites are responsible for inducing the kidney damage, females are more sensitive than males to succinimide-induced nephrotoxicity, and the stereochemistry of the metabolites contributes to nephrotoxic potential. This project seeks to determine the exact nature of the toxic metabolites and sub-cellular renal targets of the metabolites, how metabolites gain entry into the kidney and the toxicogenomics of succinimide-induced nephrotoxicity.
- Chloroanilines are commonly used chemical intermediates in the manufacture of dyes, drugs, agricultural herbicides and fungicides and thousands of other products. Exposure to a chloroaniline can result in a number of toxicities including toxicity to the blood, liver and kidney. This project seeks to determine the chemical species (parent compound or metabolite) responsible for liver and kidney damage and the mechanism by which nephrotoxicity occurs.
- Drugs and non-therapeutic chemicals are often converted to sulfate or glucuronide metabolites in the body. These metabolites are primarily formed in the liver and excreted in the bile or via the kidney. However, very little is known about how the kidney handles these metabolites. The kidney contains a number of membrane bound protein molecules that transport organic anions. This project seeks to determine if these types of metabolites are substrates for renal transporters and if so which ones are responsible for secretion or reabsorption of these types of metabolites.
- Methadone is a drug used to reduce the dependence of heroin adducts on heroin. However, some methadone users die unexpectedly when using normal doses of methadone. Preliminary studies have suggested that there may be a defect in the inactivation of methadone in the liver in these individuals who die unexpectedly. The purpose of this study is to determine if genetic polymorphisms are responsible for these deaths.
G.O. Rankin, S.K. Hong, D.K. Anestis, J.G. Ball and M. A. Valentovic. 2012.Role of leukotrienes in N-(3,5-dichlorophenyl) succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fisher 344 rats. Toxicology 300, 92-99. Epub: June 15, 2012.
G.O. Rankin, C. Racine, A. Sweeny, A. Kraynie, D.K. Anestis, and J.B. Barnett. 2008. In vitro nephrotoxicity induced by propanil. Environment. Toxicol., 23: 435-442.
G.O. Rankin, S.K. Hong, D.K. Anestis, J.G. Ball, and M.A. Valentovic. 2008. Mechanistic aspects of 4-amino-2,6-dichlorophenol-induced in vitro nephrotoxicity. Toxicology, 245: 123-129.
G.O. Rankin, S.K. Hong, and D.K. Anestis. 2008. Nephrotoxicity induced by N-(3,5-dichlorophenyl)-3-hydroxysuccinimide (3-NDHSA) in male and female Fischer 344 rats. J. Appl. Toxicol., 28(7): 867-873.
H. Luo, G.O. Rankin, Z. Li, l. Depriest and Y.C. Chen. 2011. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chemistry, 128: 513-519.
H. Luo, G.O. Rankin, N. Juliano, B.H. Jiang and Y.C. Chen. 2012. Kaemperfol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFkB-cMyc-p21 pathway. Food Chemistry 130, 321-328.
Christopher Racine – Ph.D. Candidate; M.S. from West Virginia State University
Taha Ahmad – Ph.D. Candidate; M.S. in Forensic Sciences, Marshall University School of Medicine