Joseph I. Shapiro, MD, FAHA, FACP, FASN

Dean, Joan C. Edwards School of Medicine
Department: Internal Medicine
Office: Marshall University Medical Center (MUMC) 3408
Phone: (304) 691-1700 | Fax: (304) 691-1726

Research Interests

I have been an active researcher for my entire career. My research has focused on the mechanisms by which renal disease progresses and causes cardiovascular (CV) disease. During these investigations, I have, through my collaborations with Drs. Zijian Xie, Jiang Liu and Nader Abraham become interested in the role of Reactive Oxygen Species (ROS) in Na/K-ATPase signaling and the potential for this signaling process to serve as a therapeutic target in renal and CV disease.

Slide15 Slide18

Clinical Interests

Acid-Base and Electrolyte Disturbances
Cellular Energy Metabolism
Mechanisms of Acute and Chronic Renal Failure
Renal Transplantation



American Physiological Society Cardiovascular Fellow (2013-present)
Phi Kappa Phi Honor Society (2013-present)
Castle Connolly Top Doctors (2012-present)
America’s Best Doctors (2009-present)
America’s Top Doctors (2009-present)
St. Vincent- University of Toledo Internal Medicine Excellence in Education Award (2009)

Selected Publications 

For a full listing of publications, please access PubMed.

Stenting and medical therapy for atherosclerotic renal-artery stenosis. Cooper CJ, Murphy
TP, Cutlip DE, Jamerson K, Henrich W, Reid DM, Cohen DJ, Matsumoto AH, Steffes M,
Jaff MR, Prince MR, Lewis EF, Tuttle KR, Shapiro JI, Rundback JH, Massaro JM,
D’Agostino RB Sr, Dworkin LD; CORAL Investigators. N Engl J Med. 2014 Jan
2;370(1):13-22. PMID: 24245566

Cardiotonic Steroids in Adaptation to Dietary Salt Intake. Dial L, Liu J, Shapiro JI. Curr Clin Pharmacol. 2013 Nov 11. PMID: 24219001

Involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase-mediated signaling transduction. Yan Y, Shapiro AP, Haller S, Katragadda V, Liu L, Tian J, Basrur V, Malhotra D, Xie ZJ, Abraham NG, Shapiro JI, Liu J. J Biol Chem. 2013 Nov 22;288(47):34249-58. PMID: 24121502

Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. Fedorova LV, Tamirisa A, Kennedy DJ, Haller ST, Budnyy G, Shapiro JI, Malhotra D. BMC Nephrol. 2013 Oct 4;14:209. PMID: 24090408

Passive immunization against marinobufagenin attenuates renal fibrosis and improves renal function in experimental renal disease. Haller ST, Drummond CA, Yan Y, Liu J, Tian J, Malhotra D, Shapiro JI. Am J Hypertens. 2014 Apr;27(4):603-9. PMID: 24014658

PPARδ binding to heme oxygenase 1 promoter prevents angiotensin II-induced adipocyte dysfunction in Goldblatt hypertensive rats. Sodhi K, Puri N, Kim DH, Hinds TD, Stechschulte LA, Favero G, Rodella L, Shapiro JI, Jude D, Abraham NG. Int J Obes (Lond). 2014 Mar;38(3):456-65. PMID: 23779049

Peroxisome proliferator-activated receptor δ agonist, HPP593, prevents renal necrosis under chronic ischemia. Fedorova LV, Sodhi K, Gatto-Weis C, Puri N, Hinds TD Jr, Shapiro JI, Malhotra D. PLoS One. 2013 May 15;8(5):e64436. Print 2013. PMID: 23691217

Principles of management of severe hyponatremia. Tzamaloukas AH, Malhotra D, Rosen BH, Raj DS, Murata GH, Shapiro JI. J Am Heart Assoc. 2013 Jan 23;2(1):e005199. doi: 10.1161/JAHA.112.005199. Review. No abstract available. Erratum in: J Am Heart Assoc. 2013 Aug;2(4):e000240. PMID: 23525443

Increased heme-oxygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade. Vanella L, Sodhi K, Kim DH, Puri N, Maheshwari M, Hinds TD Jr, Bellner L, Goldstein D, Peterson SJ, Shapiro JI, Abraham NG. Stem Cell Res Ther. 2013 Mar 12;4(2):28. PMID: 23497794

Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis. Haller ST, Kalra PA, Ritchie JP, Chrysochou T, Brewster P, He W, Yu H, Shapiro JI, Cooper CJ. Hypertension. 2013 Apr;61(4):894-900. PMID: 23399713

CD36 and Na/K-ATPase-α1 form a proinflammatory signaling loop in kidney. Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, Westfall K, Tian J, Bartlett DJ, Tang WH, Xie Z, Shapiro JI, Silverstein RL. Hypertension. 2013 Jan;61(1):216-24. PMID: 23172921

Gender differences in the development of uremic cardiomyopathy following partial nephrectomy: Role of progesterone. Drummond CA, Buddny G, Haller ST, Liu J, Yan Y, Xie Z, Malhotra D, Shapiro JI, Tian J. J Hypertens (Los Angel). 2013 Jan 31;2. PMID: 24404431

Stem cell transplantation increases antioxidant effects in diabetic mice. Li M, Vanella L, Zhang Y, Shi M, Takaki T, Shapiro JI, Ikehara S. Int J Biol Sci. 2012;8(10):1335-44. PMID: 23139632

Molecular mechanisms of experimental salt-sensitive hypertension. Joe B, Shapiro JI. J Am Heart Assoc. 2012 Jun;1(3):e002121. PMID: 23130148

How safe is unilateral nephrectomy? Shapiro JI, Dial LD. Hypertension. 2012 Dec;60(6):1383-4. PMID: 23071125

Ouabain-stimulated trafficking regulation of the Na/K-ATPase and NHE3 in renal proximal tubule cells. Yan Y, Haller S, Shapiro A, Malhotra N, Tian J, Xie Z, Malhotra D, Shapiro JI, Liu J. Mol Cell Biochem. 2012 Aug;367(1-2):175-83. PMID: 22618525

Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling. Liu J, Kennedy DJ, Yan Y, Shapiro JI. Int J Nephrol. 2012;2012:381320. PMID: 22518311

Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. Liu C, Bai Y, Chen Y, Wang Y, Sottejeau Y, Liu L, Li X, Lingrel JB, Malhotra D, Cooper CJ, Shapiro JI, Xie ZJ, Tian J. J Biol Chem. 2012 May 11;287(20):16390-8. PMID: 22451662

Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure. Haller ST, Kennedy DJ, Shidyak A, Budny GV, Malhotra D, Fedorova OV, Shapiro JI, Bagrov AY. Am J Hypertens. 2012 Jun;25(6):690-6. PMID: 22378033

Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia. Fedorova L, Gatto-Weis C, Smaili S, Khurshid N, Shapiro JI, Malhotra D, Horrigan T. Reprod Biol Endocrinol. 2012 Feb 23;10:15. PMID: 22360878

Ouabain and insulin induce sodium pump endocytosis in renal epithelium. Gupta S, Yan Y, Malhotra D, Liu J, Xie Z, Najjar SM, Shapiro JI. Hypertension. 2012 Mar;59(3):665-72. PMID: 22311908

Laboratory Personnel

Jiang Liu, MD, PhD – Associate Professor
Yanling Yan, PhD – Postdoctoral Fellow
Muhammad Chaudhry, MS – Research Associate
Hong C. Li, PhD – Postdoctoral Fellow
Kyle Maxwell, BS – Lab Assistant