Lawrence M. Grover, Ph.D.

Larry Grover, Ph.D.Professor
Department: Pharmacology, Physiology & Toxicology
Research Cluster: Neuroscience and Developmental Biology
Office: 435Q
Phone: 304-696-7328

Research Interests

  1. Impact of REM sleep loss on hippocampal memory functions.The hippocampus is one of the major brain structures required for memory formation. Memory formation occurs through enhancement (potentiation) of synaptic function, and memory formation is impaired by sleep disruption. We are examining how deprivation of the Rapid Eye Movement (REM) portion of sleep affects hippocampal synaptic functions related to memory. We are also examining hippocampal-dependent learning using a spatial memory task (Morris water maze). One area of focus is the potential role of hormones as mediators for the effects of REM sleep loss on hippocampal function.
  2. Models of signaling mechanisms in LTP. In the hippocampus, brief periods of high activity at excitatory synapses cause long lasting potentiation (LTP) of synaptic transmission. LTP is widely used as a cellular model for the synaptic changes which occurs during memory formation. In this project we combined experimental (my laboratory) and computation (Bill Holmes, Ohio University) approaches to model processes occurring at the cell, synapse and molecular levels during LTP.

Selected Publications

Kim E, Owen B, Holmes WR, Grover LM. Decreased afferent excitability contributes to synaptic depression during high frequency stimulation in hippocampal area CA1. J Neurophysiol. 2012 Jul 5.

Spitzer N, Sammons GS, Butts HM, Grover LM, Price EM. Multipotent progenitor cells derived from adult peripheral blood of swine have high neurogenic potential in vitro. J Cell Physiol. 2011 Dec;226(12):3156-68. 

Growth hormone rescues hippocampal synaptic function after sleep deprivation. Am J Physiol Regul Integr Comp Physiol. 2010 Jun; 298(6): R1588-96.

Mahmoud GS, Grover LM. Growth Hormone Enhances Excitatory Synaptic Transmission in Area CA1 of Rat Hippocampus. J Neurophysiol. 95: 2962-2974, 2006.

Holmes WR, Ambros-Ingerson J, Grover LM. Fitting experimental data to models that use morphological data from public databases. J Comput Neurosci 20: 349-365, 2006.

Kim EY, Mahmoud GS, Grover LM. REM sleep deprivation inhibits LTP in vivo in area CA1 of rat hippocampus. Neurosci Lett 388: 163-167, 2005.

Grover LM. Evidence for postsynaptic induction and expression of NMDA receptor independent LTP. J Neurophysiol 79: 1167-1182, 1998.

Patterson SL, Grover LM, Schwartzkroin PA, Bothwell M. Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9: 1081-1088, 1992.

Grover LM, Teyler TJ. Two components of long-term potentiation induced by different patterns of afferent activation. Nature 347: 477-479, 1990.