Department: Biochemistry and Microbiology
Research Cluster: Cancer Biology
Office: BBSC 336-S | Laboratory: BBSC 315
Phone: (304) 696-7339 | Fax: (304) 696-7207
My research interests are to identify the mechanisms of action of omega-3 fatty acids to increase the efficacy and reduce the side effects of cancer chemotherapy and to prevent cancer. It seems so simple, yet there are good biological explanations for the how dietary omega-3 fatty acids can profoundly affect the efficacy of cancer chemotherapeutic agents. These activities include altering: the potential for lipid peroxidation and free radical damage to cancer cells, prostaglandin production in cancer and normal cells, cell membrane fluidity, membrane transport, membrane permeability, the activities of the peroxisome proliferator activated receptor and/or nuclear factor kB, membrane receptor function, estrogen metabolism and the inflammatory process. We have completed much preclinical work. My future plans include continued investigation of mechanisms and conducting small clinical trials to determine whether omega 3 will provide benefit to patients with cancer.
University of Texas Health Science Center at San Antonio, Ph.D., Cell Biology, 1992
Instructor, Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, TX, 1993-1997
Research Assistant Professor, Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, TX, 1997 – 2001
Assistant Professor, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, 2001 to 2005
Associate Professor, Marshall University School of Medicine, Dept. of Biochemistry and Microbiology Huntington, WV, 2005 to 2011
Professor, Marshall University School of Medicine, Dept. of Biochemistry and Microbiology Huntington, WV, 2011 to present
Akinsete, JA, Ion, G., Witte, TR and Hardman, WE. Consumption of omega 3 fatty acids slows progression of prostate cancer in C(3)1 TAg mice. Carcinogenesis, Nov. 2011
Hardman, WE, Ion, G, Akinsete, JA, Witte, TR. Dietary walnut suppressed mammary gland tumorigenesis in the C(3)1 TAg mouse. Nutrition and Cancer, online: 20 Jul 2011
Varney, ME, Buchanan, JT, Dementieva,Y, Hardman, WE, and Vincent E. Sollars. A high omega-3 fatty acid diet has different effects on early and late stage myeloid progenitors Lipids 2011 Jan;46(1):47-57. Epub 2010 Oct 31
Hardman, WE, Sun, L.Z., Short, N. and Cameron, IL. Dietary omega-3 fatty acids and ionizing irradiation on human breast cancer xenograft growth and angiogenesis. Cancer Cell Int. 2005 Apr 28;5(1):12.
Hardman, WE. Omega 3 fatty acids to augment cancer therapy. J Nutr.132: 3508S-3512S, 2002.
Hardman, WE, Moyer, MP and Cameron, IL. Small amounts of a concentrated omega-3 fatty acid product, INCELL AAFA, in the diet reduces the side-effects of the cancer chemotherapy drug, CPT-11 (irinotecan). Br J Cancer 86(6): 983-8, 2002.
Hardman, WE, Munoz, J. and Cameron, IL. Role of lipid peroxidation and antioxidant enzymes in omega 3 fatty acids induced suppression of breast cancer xenograft growth. Cancer Cell International, 2:10, 2002.
Hardman, WE, Avula, CPR, Fernandes, G. and Cameron, IL. Three percent dietary fish oil concentrate increased efficacy of doxorubicin against MDA-MB 231 breast cancer xenografts. Clin. Cancer Res. 7: 2041-2049, 2001.
Hardman, WE and Cameron, IL. Fish oil supplementation enhances CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorates intestinal side effects. Br. J. Cancer, 81:440-448, 1999.