Zijian Xie, PhD

Zijian Xie, Ph.D.
Director, Marshall Institute of Interdisciplinary Research (MIIR)
Department: Pharmacology, Physiology and Toxicology
Office: Robert C. Byrd Biotechnology Science Center, Suite 220
Phone: (304) 696-3852
E-mail: xiez@marshall.edu

Research Interests

  • Molecular mechanism of membrane transported-mediated signal transduction
  • Development of novel agonists and antagonists of receptor Na+/K+-ATPase
  • Renal and cardiac physiology of endogenous cardiotonic steroids

A molecular biologist/pharmacologist, Dr. Xie has focused his research for nearly 30 years on an enzyme commonly referred to as the “sodium-potassium pump” because it controls the levels of potassium and sodium entering and exiting cells. This pumping process is vital to transporting essential nutrients like glucose and amino acids into cells and maintaining the electrical charge within cells, which is particularly important in controlling normal functions in nerves and muscles, as well as in the kidney and heart.

Dr. Xie’s research shows that in addition to its critical pumping function, which was discovered by scientists in the 1950s, this “pump” plays a second, distinct role by directing a variety of cellular processes in the heart, kidneys and other tissues. Through their studies to learn more about the molecular mechanisms by which this cellular signaling occurs, Dr. Xie and his colleagues are working to develop new treatments for cancer, heart and kidney disease.

Dr. Xie holds international patents and patent applications on seven medical inventions resulting from his research. He has served as principal investigator, project leader or co-investigator on National Institutes of Health-funded projects totaling more than $10 million, and has established active international collaborations with total funding of more than $1 million. He has been involved with the creation of two spin-off companies from his research.

Selected Publications 

For a full listing of publications, please access PubMed.

Drummond CA, Sayed M, Evans KL, Shi H, Wang X, Haller ST, Liu J, Cooper CJ, Xie Z, Shapiro JI, Tian J. (2014)  Reduction of Na/K-ATPase affects Cardiac Remodeling and Increases c-kit cell abundance in Partial Nephrectomized Mice. Am J Physiol Heart Circ Physiol. 2014 Apr 18. [Epub ahead of print]

Wang Y, Ye, Q, Liu C, Xie JX, Yan Y, Lai F, Duan Q, Li X, Tian J, Xie Z (2014) Involvement of Na/K-ATPase in hydrogen peroxide-induced activation of the Src/ERK pathway in LLC-PK1 cells. Free Radic Biol Med. 2014 Apr 1. pii: S0891-5849(14)00153-1. doi: 10.1016/j.freeradbiomed.2014.03.036. [Epub ahead of print]

Xie JX, Li X and Xie Z (2013) Regulation of renal function and structure by the signaling Na/K-ATPase. IUBMB Life, in press.

Yan Y, Shapiro AP, Haller S, Katragadda V, Liu L, Tian J, Basrur V, Malhotra D, Xie ZJ, Abraham NG, Shapiro JI, Liu J. (2013) The Involvement of Reactive Oxygen Species in a Feed-Forward Mechanism of Na/K-ATPase Mediated Signaling Transduction. J Biol Chem, in press

Lai F, Madan N, Ye Q, Duan Q, Li Z, Wang S, Si S, Xie Z (2013) Identification of a Mutant α1 Na/K-ATPase That Pumps but is Defective in Signal Transduction. J. Biol. Chem. 288(19):13295-304

Ye Q., Lai F., Banerjee M., Duan Q., Li Z., Si S., and Xie Z. (2013) Expression of Mutant a1 Na/K-ATPase Defective in Conformational Transition Attenuates Src-mediated Signal Transduction. J Biol Chem 288:5803-5814.

Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, Westfall K, Tian J, Bartlett DJ, Tang WH, Xie Z, Shapiro JI, Silverstein RL. (2013) CD36 and Na/K-ATPase-α1 form a proinflammatory signaling loop in kidney. Hypertension, 61:216-224. PMID: 23172921

Liu C, Bai Y, Chen Y, Wang Y, Sotterjeau Y, Liu L, Li X, Lingrel JB, Malhotra D, Cooper CJ, Shapiro JI, Xie ZJ and Tian J. Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. J. Biol. Chem 2012 in press

Li Z, Zhang Z, Xie JX, Li X, Tian J, Cai, T, Cui, H, Ding H, Shapiro J. and Xie Z. Na/K-ATPase mimetic pNaKtide inhibits the growth of human cancer cells. J Biol. Chem. 286: 32394-403, 2011

Liu J, Yan Y, Liu L, Xie Z, Malhotra D, Joe B, Shapiro JI Impairment of Na/K-ATPase signaling in renal proximal tubule contributes to Dahl salt-sensitive hypertension. J Biol. Chem. 286:22806-13, 2011

Chen Y., Li X., Ye, Q., Tian J., Jin R., and Xie Z Regulation of a1 expression by cholesterol. J Biol. Chem. 286: 15517-24, 2011.

Ye Q, Li Z, Tian J, Xie J, Liu, L and Xie Z Identification of a potential receptor that couples ion transport to protein kinase activity. J Biol Chem 286:6225-32, 2011.

Zhang Z, Li Z, Tian J, Jiang W, Wang Y, Zhang X, Li Z, You Q, Shapiro JI, Si S, and Xie Z. Identification of Hydroxyxanthones as Na/K-ATPase ligands. Mol Pharmacol, 77:961-7, 2010.

Tian, J., Haller, S., Periyasamy, S., Brewster, P., Zhang, H., Adlakha, S., Fedorova, OV., Xie Z., Bagrov, AY., Shapiro JI., and Cooper CJ. Renal ischemia regulates marinobufagenin release in humans. Hypertension, 56:914-9, 2010.

Quintas, L.E., Pierre, S.V., Liu, L., Bai, Y., Liu, X., and Xie, Z.J.  Alterations of Na(+)/K(+)-ATPase function in caveolin-1 knockout cardiac fibroblasts.  J. Mol. Cell. Cardiol., 49:525-31,2010.

Laboratory Personnel

Sandrine V Pierre, PhD – Associate Investigator & Education Coordinator
Moumita Banerjee, PhD – Post-doctoral Fellow
Namrata Madan – Graduate Student
Rosana Alves, MD – Visiting Scholar
Xiaoyu Cui – Graduate Student
Xiaoliang Wang, MD – Graduate Student
Hui Yu, MD, PhD – Visiting Scholar
Yunhui Xu – Graduate Student
Jue Zhang, MD – Graduate Student
Ying Wang – Post-doctoral Fellow
Lanqing Wu – Research Assistant
Minqi Huang – Biomedical Sciences, MS Student
Jainne Martins Ferreira, PhD – Visiting Scholar