Christopher Racine, a fourth year Biomedical Sciences Ph.D. Candidate, won the Ohio Valley Regional Chapter/Charles River Laboratories Best Ph.D. Student Poster Presentation Award at the Ohio Valley Regional Society of Toxicology meeting held at the University of Louisville, Louisville Kentucky.
Mr. Racine’s poster was entitled, “Role of renal biotransformation in 1,2,3-trichloro-4-nitrobenzene induced nephrotoxicity in vitro,” and co-authored by Travis Ferguson, Deborah Preston, Dianne K. Anestis and Dr. Gary O. Rankin. The project was designed to begin to determine how 1,2,3-trichloro-4-nitrobenzene, a commonly used chemical intermediate, causes damage to the kidney. Racine’s work explored if the kidney could directly change the chemical to a toxic form and whether oxidative damage might play a role in how the nitrobenzene compound damaged kidneys. His work documented that several different metabolizing enzyme systems could change the nitrobenzene compound to new toxic compounds called metabolites that harmed the kidney cells. He also found that chemical-induced oxidative damage was contributing to the mechanism by which the nitrobenzene was causing kidney toxicity.
Future work will explore which toxic metabolites are formed from 1,2,3-trichloro-4-nitrobenzene and what parts of the kidney cells these metabolites attack. Mr. Racine is currently conducting his research in the laboratory of Dr. Gary O. Rankin, Professor and Chair of the Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine.