Daron-Mathis successfully earns her Ph.D.

Sarah Daron-Mathis has successfully defended her dissertation entitled: Cancer Stem Cells in the Screening of Anticancer Drugs for Central Nervous System Tumors. This research focused on the development of a test to predict the outcome of specific therapeutic treatments to give an individual patient the best results. After a surgery, it is often difficult to know which anti-cancer drug(s) will be most effective in continuing to treat a tumor. Daron-Mathis stated,The test is novel in that it not only looks at the whole tumor, but also at the subpopulation that is resistant and causes relapse in a patient. Determining the chemotherapeutic drug that will work on the whole of the tumor and also this resistant population, we can better predict which drug will give the patient the most optimal outcome.”

Sarah Daron-Mathis 4.28.15 Use2Pier Paulo Claudio. M.D./Ph.D., Sarah’s mentor, noted that Sarah has “conducted progressive, out-of-the-box, cancer research in the Translational Laboratories at the McKown Translational Genomic Research Institute (TGRI), Edwards Cancer Center,” as well as spending six months doing research at the National Center for Research in Rome, Italy. For that experience, “several experiments involving the effects of microgravity on stem cell growth were repeated by an independent laboratory,” Dr. Claudio stated. Claudio also pointed out several successful presentations at STaR Symposium, the American Society for Gravitational Space Biology, the American Institute for Cancer Research conference in Washington DC, the Cell Differentiation and Development Center symposium, the Center for Clinical and Translational Science Spring Conference, the Annual Marshall University Research Day at the School of Medicine, the Appalachian Regional Cell Conference, and Life in Space for Life on Earth that was held in France. Notably, Sarah won three First Place Posters during these conferences.

As Daron-Mathis reflected upon her time in the Biomedical Program, she found that it had not been easy but she had the strength to persevere. “I worked with people from all over the world and not only gained scientific experience but also culture and friendship. I am very thankful to my committee for their understanding as I worked through medical problems. If it wasn’t for that support, I would not have finished. In the last six years I was diagnosed with Multiple Sclerosis, married, began to raise a family, learned Bujinkan Budo Taijutsu, had a baby girl, and now have received my Ph.D. Getting the Ph.D. was the second hardest thing I have ever done (having my daughter is by far #1.)”

Congratulations, Sarah Daron-Mathis, Ph.D. on everything that you have accomplished!

Nande successfully defends dissertation

NandeRounak P. Nande successfully defended his dissertation: Investigation of ultrasound -targeted microbubbles as a therapeutic gene delivery system for prostate cancer. Nande’s research in the laboratory of Pier Paulo Claudio, M.D./Ph.D., focused on utilizing these microbubbles to carry adenoviral vectors with therapeutic genes to a cancerous tumor site. This delivery is shielded from discovery and quick deterioration by the immune system. According to Rounak, “this is particularly important in cancer gene therapy for potentially inaccessible tumors because the microbubbles may also limit the amount of inflammatory response to the viruses and may allow repeated injections. Thus, our novel viral delivery technique mediated by microbubbles and ultrasound brings new hope to the frontier of gene therapy and its use in clinical settings.​​”

Rounak has presented several posters of his research at different conferences in the USA such as American Society of Gene and Cell Therapy (ASGCT), Star Symposium, Center for Clinical and Translational Science (CCTS), Experimental Biology Conference (EB), Annual Research Day at the school of medicine, and the Appalachian Regional Cell Conference (ARCC). Also, he has presented orally at the annual research day for four consecutive years. Rounak’s “accolades include receiving a travel award from Marshall University for the Experimental Biology Conference, and a paid trip to an international meeting for winning the Best Overall Performance as a Graduate Student award in 2014. Additionally, since ARCC’s inception, Rounak has won 1st or 2nd place in poster competition for every ARCC conference entered. Lastly, he has received the NASA West Virginia space grant in the years 2013-2014 and 2014-2015,” said Dr. Pier Paulo Claudio, Nande’s mentor. Claudio also stated that Nande’s research has resulted in two publications – a first author and a second author – in addition to a book chapter in Cutting Edge Therapies for Cancer in the 21st Century.

Congratulations on your graduation, Rounak Nande, Ph.D.!

Marshall University Joan C. Edwards School of Medicine hosts 27th annual Research Day – Winners Announced

Congratulations to two Biomedical Sciences Ph.D. students for winning best oral and best poster presentations at the recent Marshall University JCE School of Medicine 27th Annual Research Day!

Winner of Basic Science Poster Presentation
Fischer, AdamAdam Fischer, Ph.D. student
, works in Dr. Sarah Miles’ laboratory and presented a poster titled “Normoxic accumulation and activity of HIF-1 is associated with ascorbic acid transporter expression and localization in human melanoma”. The other author is Sarah L. Miles.

 

 

 

 

Winner of Basic Science Oral Presentation
Kristeena Ray_web
Kristeena Wright, Ph.D. candidate, works in Dr. Nalini Santanam’s laboratory and gave an oral presentation titled “Polycomb group and associated proteins as potential therapeutic targets for endometriosis”. Other authors include Brenda Mitchell and Nalini Santanam. 

 

 

Winners of clinical categories are as follows:

Clinical Science Oral Presentation, Student CategoryBrandon J. Smith
“Impact of influenza vaccination on clinical outcomes of patients admitted in a university affiliated large medical center in Pittsburgh, Pennsylvania”

Clinical Science Oral Presentation, Resident CategoryA. Allison Roy
“Evaluating Buprenorphine Metabolism in Cord Blood from Neonates Born to Opiate Addicted Mothers as a Predictor of Neonatal Abstinence Syndrome in Rural Appalachia”

Clinical Case Poster Presentation, Student CategoryPaul Viscuse
“Fatigue, bruising, and weight loss in a teenage female with previously diagnosed thrombocytopenia”

Clinical Case Poster Presentation, Post-Graduate CategoryZain Qazi
“Atypical Growth of an Osteochondroma in a 31 year old female”

Clinical Science Poster Presentation, Student CategoryMaria Espiridion
The Medicare Annual Wellness Visit: Barriers and Patient Perceptions”

Clinical Science Poster Presentation, Post-Graduate CategoryJared Brownfield
“Placental ADRB1 mRNA as a Potential Predictor of Outcome and Possible Therapeutic Target in High Risk Pregnancies”

Earlier Press Release:

HUNTINGTON, W.Va. – Nearly 100 research projects and a keynote presentation focused on one of the region’s most pressing health problems, obesity, will mark the Joan C. Edwards School of Medicine’s Health Sciences Center 27th Annual Research Day at Marshall University.

The two-day research event begins at 5:30 p.m. Monday, March 23, with a community seminar on obesity, co-sponsored by Cabell Huntington Hospital (CHH) and its Senior Services Program.

Richard J. Johnson, M.D., chief of the division of renal disease and hypertension at the University of Colorado, will serve as special guest speaker for both the community event and Marshall’s academic event.

Johnson graduated from the University of Minnesota Medical School and then completed a residency in internal medicine and fellowships in nephrology and infectious diseases at the University of Washington in Seattle.

Johnson’s community presentation, “Obesity,” is focused on the causes of weight gain and overall energy balance and concerns about the intake of added sugars containing fructose in the Western diet.  The lecture, which is free and open to the public, begins at 5:30 p.m. in the Harless Auditorium of the Marshall University Medical Center on the campus of Cabell Huntington Hospital.  The following day, Tuesday, March 24, Johnson also will deliver a lecture to medical students, residents and other medical personnel in the Harless Auditorium. The lecture, which begins at 11:30 a.m., is titled, “The Role of Sugar (Fructose) in the Great Epidemics of Diabetes and Obesity.”

Research Day showcases research conducted by medical students, graduate students, residents and postdoctoral fellows.   This year’s entries include a variety of projects that focus on various areas in medical and biomedical research. “The topic of our research day, obesity, is very important since most of the serious health care disparities affecting West Virginians result from obesity,” said Uma Sundaram, M.D., vice dean for research at the School of Medicine. “The presentations by Dr. Johnson and the cutting-edge research that will be presented during the research day illustrate our commitment to education, prevention and treatment of obesity and its many complications in West Virginia.”

For more information about Research Day contact the Office of Continuing Medical Education at 304-691-1770.

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Recent Biomedical Sciences graduate, Miranda Carper, PhD, publishes in prestigious journal

Miranda Carper, Ph.D., a December 2014 graduate of Marshall University’s Joan C. Edwards School of Medicine Biomedical Sciences Ph.D. program, had her manuscript published in Genes and Cancer, a leading journal in the field. Dr. Carper worked in the lab of Pier Paolo Claudio, M.D./Ph.D.

RGS16, a novel p53 and pRb cross-talk candidate inhibits migration and invasion of pancreatic cancer cells focuses on the identification of a protein that is able to inhibit Carper, Miranda_12.14.14pancreatic cancer cell invasion and migration. The research provides information on why this protein is down-regulated in metastatic pancreatic cancer and makes the case for continued investigation. Read the entire article here (November Issue): http://www.impactjournals.com/Genes&Cancer/files/papers/1/43/43.pdf.

Congratulations on your publication and recent graduation, Dr. Miranda B. Carper!

Multi-million dollar federal grant renewed for Marshall researchers and statewide collaborators

HUNTINGTON, W.Va. – Dr. Gary Rankin with the Marshall University Joan C. Edwards School of Medicine and co-investigators at institutions around West Virginia, including West Virginia University, have received a five-year renewal grant from the National Institutes of Health (NIH) totaling more than $17 million for the West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE).

Rankin, who is chairman of the department of pharmacology, physiology and toxicology, serves as the grant’s principal investigator.

Gary O. Rankin, Ph.D.“We are really happy to be able to continue the work of the WV-INBRE program across our state,” Rankin said. “These funds will provide much-needed support for investigators at West Virginia colleges and universities to develop biomedical research programs and receive critical new equipment for their research activities.”

Rankin explained that researchers with the WV-INBRE research network are already studying many important health issues germane to West Virginia including cancer and cardiovascular disease, and the grant allows for expansion in those areas.

“The grant will also allow us to continue providing biomedical research opportunities for undergraduate students and faculty in all parts of West Virginia and help us train the state’s future workforce in science and technology,” Rankin said.

WV-INBRE is part of NIH’s Institutional Development Award (IDeA) program housed in the National Institute of General Medical Sciences (NIGMS) at NIH. The goals of the IDeA programs are to enhance biomedical research capacity, expand and strengthen the research capabilities of biomedical faculty, and, for INBREs, provide access to biomedical resources for promising undergraduate students throughout the 23 eligible states and Puerto Rico in the IDeA program.

“Our INBRE puts the IDeA approach into action by enhancing the state’s research infrastructure through support of a statewide system of institutions with a multidisciplinary, thematic scientific focus,” Rankin said. “For WV-INBRE this focus is cellular and molecular biology, with a particular emphasis on chronic diseases. We have also started an initiative to support natural products research in the areas of cancer and infectious disease research.”

Rankin said the research goals are accomplished through mentoring and administrative support provided by both Marshall University and West Virginia University.

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Contact: Leah C. Payne, Director of Public Affairs, Schools of Medicine and Pharmacy, 304-691-1713

Pier Paolo Claudio, M.D., Ph.D. shares ChemoID results with prominent scientists

Pier Paolo Claudio, M.D., Ph.D. (Marshall University Graduate Faculty, Cancer Biology research cluster), was an invited speaker at the prestigious Cancer Stem Cell Conference at Case Western University in August. Claudio traveled to Cleveland, OH to provide the ChemoID clinical trial data for the Central Nervous System (CNS) tumor series in a presentation titled: Chemosensitivity Assay for Targeting Cancer Stem-Like Cells in Malignant Brain Tumors. His work was well-received by the 500 world-renowned, national, and international cancer scientists who attended the conference. The opportunity to present his results was “extremely rewarding,” said Claudio.

ChemoID is the result of Claudio’s focus on translational research which is aimed at taking laboratory discoveries to a patient’s bedside. He and his collaborators have developed a method of forecasting the efficacy of particular chemotherapy drugs on specific individuals diagnosed with certain types of cancers. This tool for choosing the best personalized therapy for cancers such as brain, lung, or breast, in addition to others, has shown very positive results in the clinical trials leading to hospital use of the technology.

ClaudioOn October 15, the Edwards Comprehensive Cancer Center will implement ChemoID. Additionally, transportation stability studies have shown that national and international samples can be safely sent to Claudio’s lab paving the way for broad use of this method.

Claudio noted that, “among all the talks presented at the meeting, we were one of the few institutions presenting an actual completed clinical trial with promising results. This certainly increased our national exposure and the number of collaborations with other leading institutions in the field.”

Philippe Georgel, Ph.D. shares research expertise internationally

Philippe Georgel, Ph.D., a member of the Biomedical Sciences Graduate Program faculty in the Cancer Biology and Neuroscience and Developmental Biology research clusters, and the Biochemistry and Microbiology Department of the Joan C. Edwards School of Medicine, was recently invited to share his research on prostate cancer and diet. The first Indo-Global Health Care Summit and Expo in Hyderabad, India, hosted his presentation to over 4000 international health care professionals on June 20-23.

Philippe Georgel, Ph.D.Dr. Georgel’s work focuses on the role of the biomolecule sulforaphane (abundant in broccoli, cauliflower and several other cruciferous plants) on prostate cancer cells. The videos of his appearance are available through the Indus Foundation web sites: http://indus.org/healthcare/Secientific_Sessions.html and http://indus.org/healthcare/gallery.html .

After the summit, Dr. Georgel met with students and faculty from universities in the Hyderabad area as an ambassador for INTO Marshall University. This program offers international students learning experiences and services that promote academic, professional and personal success at Marshall University’s Huntington campus. Often, these students then matriculate into Marshall’s undergraduate or graduate degree courses. Dr. Georgel discussed some potential benefits of studying at Marshall University such as the supportive local community, small campus setting, friendly people, and travel highlights of living in the Tri-State region. He also provided detailed information about the curricula offered by the College of Science.

Thank you, Dr. Georgel, for spreading the word internationally about the outstanding research and opportunities at Marshall.