Biomedical sciences researcher to present results of clinical trials on personalized chemotherapy

HUNTINGTON, W.Va. – Dr. Pier Paolo Claudio, a researcher at the Marshall University Joan C. Edwards School of Medicine, is traveling to Paphos, Cyprus, next month to present his work to personalize chemotherapy for cancer treatment.

Claudio was invited to give the talk at the 5th International Conference on Recent Advances in Health and Medical Sciences, which will be held July 6-12.

He will be discussing the results of clinical trials conducted at the Edwards Comprehensive Cancer Center. The studies tested ChemoID, a cell culture method he developed with colleague Dr. Jagan Valluri to measure the sensitivity of patients’ tumors to chemotherapy treatment for lung, brain/spine and breast cancer.

He says more evaluation of the technology is needed, but preliminary tests on a small number of patients found ChemoID 100 percent accurate in predicting which drug is more effective in treating patients affected by brain cancer if the tumor-initiating cancer stem cells were evaluated.

Claudio“Oncologists every day face many challenges in determining the best course of therapy for an individual cancer patient,” says Claudio. “The basic problem is that patients with similar diagnoses don’t always respond to the same chemotherapy. This technology we have developed could help physicians select the appropriate chemotherapy for an individual patient—giving them an edge in the fight against cancer.”

He says the good news for cancer patients is that ChemoID may make possible personalized treatment by predicting the most effective drug combination to successfully target that specific patient’s cancer—increasing the chance the drugs will work and perhaps reducing side effects by helping the patient avoid unnecessary drugs.

In addition to presenting his own research at the conference, Claudio will be moderating a session, “Advances in Oncology and Anticancer Research. Cancer Pathology.”

Summaries of the research presented at the meeting will be published in the journal Frontiers in Bioscience.

###

Contact:  Ginny Painter, Communications Director, Marshall University Research Corporation, 304-746-1964 (o) www.marshall.edu/murc

Researcher receives $432,000 grant to study progression of cancer, involve students

The following news story provides different information about Dr. Sollars’ research than the previous one posted on our News page.

HUNTINGTON, W.Va. – Dr. Vincent E. Sollars, an associate professor of biochemistry and microbiology at the Marshall University Joan C. Edwards School of Medicine, has received a $432,000 grant from the National Cancer Institute to research a cutting edge concept to fight cancer.

The Academic Research Enhancement Award (AREA) will fund a three-year project in “epigenetics,” a relatively new concept in cancer therapies that has shown great promise.

“The basic question we are trying to answer is ‘What are the processes that enable a normal cell to start misbehaving and become cancer cells?’” says Sollars.

As he explains, the process that cells undergo to become cancer cells ultimately produces a cell that stops listening and cooperating with neighboring cells. That communication, however, is necessary for the complex mixture of cells our bodies contain.

He says, “This grant will investigate a process known as ‘canalization.’ Much like a canal for water directs the flow of water, canalization directs a cell as it matures into the specific type of cell needed by the body. Disrupting the canalization process can cause a cell to change and lose its direction, potentially pushing it down paths that lead to cancer.”

Sollars said his team will be testing the role of Vincent-Sollars-2012canalization in the process of maturing cells and cancer development. They will be targeting leukemia specifically with this grant but the results of their study can apply to all types of cancers.

“We think our work can have a great impact on science’s understanding of  how cancer progresses and will even help develop new treatments for most cancers,” he added.

This particular award is specifically designed to give students practical opportunities to participate in cutting-edge academic research. Over the course of the project, Sollars anticipates involving eight students from Marshall’s undergraduate and graduate programs, as well as students from the medical school. The grant also will fund a full-time technician.

The National Cancer Institute, part of the National Institutes of Health, is the federal government’s principal agency for cancer research and training.

Contact:  Ginny Painter, Communications Director, Marshall University Research Corporation, 304-746-1964 (o) or 304-552-1287 (c), www.marshall.edu/murc

###

Grant to fund MU’s new cancer research

HUNTINGTON — A new concept in cancer treatment will be future explored at Marshall University thanks to a grant from the National Cancer Institute.

The U.S. Department of Health and Human Services (HHS) National Cancer Institute awarded a $432,369 three-year Academic Research Enhancement Award to the Marshall Vincent-Sollars-2012University Joan C. Edwards School of Medicine to launch a cancer biology research project in “epigenetics,” a relatively new concept in cancer therapies, according to a press release from Rep. Nick Rahall, D-W.Va.

The concept deals with a new chemotheraputic target in cancer treatment, said Dr. Vincent E. Sollars, an associate professor of biochemistry and biology at Marshall.

“It’s a great way for me and the students to get involved in some research I’ve wanted to do for some time,” Sollars said. “We’re targeting leukemia specifically with this grant, but the this could have ramifications on all types of cancers.”

Over the course of the three-year project, Marshall University anticipates involving eight students from undergraduate, master’s and doctoral academic programs, as well as students enrolled in the med school.

Sollars said the medical school also will hire a full time technician through the grant.

BMS associate professor invited to chair at international meeting

Dr. Piyali Dasgupta has been invited to chair a minisymposium entitled “Lung Cancer” at the Experimental Biology (EB) 2014 conference in San Diego. The invitation to chair the special session came from the American Society for Investigative Pathology (ASIP).

When asked to comment on being selected for this position, Dr. Dasgupta replied: “The ‘chair’ is selected based on their research and publications in the field of lung cancer. So, we feel thrilled that our work is being noticed by other researchers at an international level.”

piyali_dasguptaDr. Dasgupta is a member of the ASIP and has regularly presented at Experimental Biology over the past few years, including several oral seminar presentations. In 2012, she was invited to chair a special session at the EB 2012 entitled “Modeling Cancer: Biological and Therapeutic Implications.”

Experimental Biology is an annual meeting that draws almost 14,000 scientists and exhibitors. Scientists attending represent universities, academic institutions, government agencies, private corporations, and non-profit organizations. Participating societies include the ASIP, the American Association of Anatomists (AAA), the American Physiological Society (APS), the American Society for Biochemistry and Molecular Biology (ASBMB) and others.

Dr. Dasgupta is Associate Professor in the Department of Pharmacol­ogy, Physiology, and Toxicology. She received the “Dean’s award for Excellence in Basic Research, 2013” at the Joan C. Edwards School of Medicine, Marshall University. Her research examines the effects of nicotine (the active component of cigarettes) in regulating cellular responses, such as programmed cell death and cell growth, in the context of lung cancer. Dr. Dasgupta will have the opportunity to share her research by giving an oral presentation in addition to serving as chair of the Lung Cancer minisymposium.

Being asked to chair a session at such a prestigious conference is quite an honor. Congratulations to Dr. Piyali Dasgupta!

For more information, please visit: https://www.asip.org/meetings/2014/minisymposia.cfm.

School of Medicine Research Day Winners

Congratulations to School of Medicine Research Day award recipients, Biomedical Sciences Ph.D. student Caroline Hunter and Ph.D. candidate Allison Wolf!

CarolineandKoc13

Caroline (on left) with her mentor, Emine Koc, Ph.D.

Best Poster Presentation in the Basic Science Category
BMS Ph.D. student Caroline A. Hunter – Mitochondrial Elongation Factor Tu:  Translational Regulation by Phosphorylation
Mentor: Emine Koc, Ph.D.

 

 

 

 

Allison_W_2014_OralWinner

Allison (on left) receiving award from Mr. Bailey

Best Oral Presentation in the Basic Science Category
BMS Ph.D. candidate M. Allison Wolf – – Benzyl Isothiocyanate Sensitizes Hnscc Cells To Cisplatin, And Inhibits Hnscc Cell Migration And Invasion
Mentor: Pier Paolo Claudio, M.D./Ph.D.

 

 

 

There were many clinical categories in addition to the two basic science categories. Those winners are listed below.

Research Day winners announced

HUNTINGTON, W.Va. – The 26th annual Research Day at the Marshall University Joan C. Edwards School of Medicine wrapped up earlier this week with awards presented to eight students and medical residents.

The two-day event showcases the work of medical students, graduate students, residents and postdoctoral fellows, and includes both poster and oral presentation competitions. This year’s entries included projects that focused on heart disease, children and physical activity, lung and other cancers, drug abuse during pregnancy, and many other areas of biomedical and clinical research.

The winners were:

POSTER PRESENTATIONS

Basic Science Category
Caroline A. Hunter – Mitochondrial Elongation Factor Tu:  Translational Regulation by Phosphorylation
Department of Biochemistry and Microbiology

Clinical Case Study Category (Student)
Jill Goodwin – Posterior Tibial Tendon Dislocation:  A Case Report
Department of Orthopaedics

Clinical Case Study Category (Resident)
M. Adeel Mahmood – An Atypical Presentation of Adrenal Insufficiency in Pregnancy as Recurrent Abdominal Pain
Department of Internal Medicine

Clinical Science Category (Student)
Laura G. Wilson – Withdrawing into Society: Characteristics of Neonatal Abstinence Syndrome on Final Day of Admission
Department of Pediatrics

Clinical Science Category (Resident)
Heidi Michael – Retrospective analysis of patients entering the Maternal Addiction and Recovery Center (MARC) program evaluating pregnancy and neonatal outcomes
Department of Obstetrics and Gynecology

ORAL PRESENTATIONS

Basic Science Category
M. Allison Wolf – Benzyl Isothiocyanate Sensitizes Hnscc Cells To Cisplatin, And Inhibits Hnscc Cell Migration And Invasion
Department of Biochemistry and Microbiology

Clinical Science Category (Student)
Rebecca M. Hayes – Development of Phone Application for Congestive Heart Failure Patients in a Rural Setting
Department of Internal Medicine

Clinical Science Category (Resident)
Jodi Pitsenbarger – Total Postnatal Opiate Exposure Using Two Different Weaning Methods in Infants with Neonatal Abstinence Syndrome
Department of Pediatrics

Dr. Richard M. Niles, vice dean for biomedical sciences at the school of medicine, congratulated all the winners, saying, “We had more than 80 presentations this year and the competition was outstanding. It is quite exciting to see all the fascinating research being done at our medical school and to know these students will be making a real difference in the lives and health of those who live in our communities.”

For more information about Research Day, contact the Office of Continuing Medical Education at 304-691-1770.

WV Undergraduate Research Day at the Capitol 2014

Image for WVURD14

Following the poster presentations, a luncheon was held to honor the student researchers, their mentors, and to formally recognize the winners of grants awarded by The Higher Education Policy Commission’s (HEPC) Division of Science and Research.

The luncheon was sponsored by the WV HEPC Division of Science and Research; Expansion of STEM Doctoral Education Program, Marshall University; Marshall Health; and WVU’s Office of Graduate Education and Life.

Norton_WVURD_grant'14One of the award recipients is one of Marshall’s own, Dr. Michael Norton. Norton received a Summer Undergraduate Research Experience (SURE) Grant for $210,000.

Congratulations!

 

 

MU biomedical students showcase research

BILL ROSENBERGER
The Herald-Dispatch

HUNTINGTON — Medical research that has an opportunity to affect the health and well-being of the general population should be celebrated, which is one of the reasons for the showcase at Pullman Plaza Hotel.

More than a dozen projects by Marshall University biomedical science graduate students and faculty members showcased their work as part of the ninth annual Biomedical Sciences Retreat. The event gives graduate students in the university’s biomedical sciences program an opportunity to share their research, including projects to study the effects of drugs on the kidney, obesity and type 2 diabetes, and how neurons respond to different patterns of neural activity.

Elsa Mangiarua, a professor in the Department of Pharmacology, Physiology and Toxicology, said Ph.D. students get to share their work with each other, while newly admitted Ph.D. students get to see some of the research they will be getting into.

“There are a lot of good projects with positive results in translational research,” said Rachel Murphy, who is a first-year student from Kansas. “It sets the bar high to help medical science advance to the next step. It’s definitely inspiring.”

Marcus_Terneus2013That was also the observation from Marcus Terneus, senior manager of global EH&S occupational toxicology at Mylan Pharmaceuticals. He is a 2006 graduate of the Marshall Ph.D. program and served as the afternoon’s keynote speaker.

“I’m very proud. It’s exciting to see the growth and what projects are going on,” Terneus said. “I keep close eyes on what students are doing.”

He also told the group that the education and research opportunities he received prepared him for what he’s seen during the past seven years.

“It’s given me what I needed to succeed,” he said.

The research also was noted as impressive because of how groundbreaking the results could be. Second-year student Justin Tomblin’s project centered on the link between obesity and breast cancer and how to block the growth of abnormal tissue.

In West Virginia, which has high obesity rates, that kind of research could help quite a few folks, he said.

“It definitely feels like you are doing something that may help friends or relatives,” Tomblin said.

John Maher, the vice president for research at Marshall and executive director of the Marshall University Research Corporation, said after hearing some presentations that Marshall has a very strong biomedical sciences program. He also noted that they are working on relevant and important problems pertaining to regional health care.