School of Medicine Research Day Winners

Congratulations to School of Medicine Research Day award recipients, Biomedical Sciences Ph.D. student Caroline Hunter and Ph.D. candidate Allison Wolf!

CarolineandKoc13

Caroline (on left) with her mentor, Emine Koc, Ph.D.

Best Poster Presentation in the Basic Science Category
BMS Ph.D. student Caroline A. Hunter – Mitochondrial Elongation Factor Tu:  Translational Regulation by Phosphorylation
Mentor: Emine Koc, Ph.D.

 

 

 

 

Allison_W_2014_OralWinner

Allison (on left) receiving award from Mr. Bailey

Best Oral Presentation in the Basic Science Category
BMS Ph.D. candidate M. Allison Wolf – - Benzyl Isothiocyanate Sensitizes Hnscc Cells To Cisplatin, And Inhibits Hnscc Cell Migration And Invasion
Mentor: Pier Paolo Claudio, M.D./Ph.D.

 

 

 

There were many clinical categories in addition to the two basic science categories. Those winners are listed below.

Research Day winners announced

HUNTINGTON, W.Va. – The 26th annual Research Day at the Marshall University Joan C. Edwards School of Medicine wrapped up earlier this week with awards presented to eight students and medical residents.

The two-day event showcases the work of medical students, graduate students, residents and postdoctoral fellows, and includes both poster and oral presentation competitions. This year’s entries included projects that focused on heart disease, children and physical activity, lung and other cancers, drug abuse during pregnancy, and many other areas of biomedical and clinical research.

The winners were:

POSTER PRESENTATIONS

Basic Science Category
Caroline A. Hunter – Mitochondrial Elongation Factor Tu:  Translational Regulation by Phosphorylation
Department of Biochemistry and Microbiology

Clinical Case Study Category (Student)
Jill Goodwin – Posterior Tibial Tendon Dislocation:  A Case Report
Department of Orthopaedics

Clinical Case Study Category (Resident)
M. Adeel Mahmood – An Atypical Presentation of Adrenal Insufficiency in Pregnancy as Recurrent Abdominal Pain
Department of Internal Medicine

Clinical Science Category (Student)
Laura G. Wilson – Withdrawing into Society: Characteristics of Neonatal Abstinence Syndrome on Final Day of Admission
Department of Pediatrics

Clinical Science Category (Resident)
Heidi Michael – Retrospective analysis of patients entering the Maternal Addiction and Recovery Center (MARC) program evaluating pregnancy and neonatal outcomes
Department of Obstetrics and Gynecology

ORAL PRESENTATIONS

Basic Science Category
M. Allison Wolf – Benzyl Isothiocyanate Sensitizes Hnscc Cells To Cisplatin, And Inhibits Hnscc Cell Migration And Invasion
Department of Biochemistry and Microbiology

Clinical Science Category (Student)
Rebecca M. Hayes – Development of Phone Application for Congestive Heart Failure Patients in a Rural Setting
Department of Internal Medicine

Clinical Science Category (Resident)
Jodi Pitsenbarger – Total Postnatal Opiate Exposure Using Two Different Weaning Methods in Infants with Neonatal Abstinence Syndrome
Department of Pediatrics

Dr. Richard M. Niles, vice dean for biomedical sciences at the school of medicine, congratulated all the winners, saying, “We had more than 80 presentations this year and the competition was outstanding. It is quite exciting to see all the fascinating research being done at our medical school and to know these students will be making a real difference in the lives and health of those who live in our communities.”

For more information about Research Day, contact the Office of Continuing Medical Education at 304-691-1770.

Marshall School of Medicine researchers and students

HUNTINGTON, W.Va. – Researchers with the Joan C. Edwards School of Medicine will present their findings at the national Orthopaedic Research Society (ORS) meeting in New Orleans that began Saturday.

Maria Serrat, Ph.D.Dr. Maria A. Serrat, assistant professor in the department of anatomy at the school of medicine and a clinical assistant professor in the department of orthopaedics, will present her team’s research model on the effects of temperature on the acceleration of bone growth in mice.

“We developed a model to study how the application of heat on the body’s surface can stimulate bone elongation,” Serrat said.  “By validating this model, we are looking at future possible clinical treatments to lengthen bones in children with growth issues or orthopaedic trauma using non-invasive methods.”

Serrat’s team includes Dr. Franklin D. Shuler, a professor in the department of orthopaedics, vice chair of research for the department of orthopaedics, and medical director for the Senior Fracture Program at Cabell Huntington Hospital. He says the opportunity to present on this national platform speaks highly of Marshall’s program.

“To have a podium presentation at this high-level meeting truly indicates that the faculty at Marshall are participating in leading-edge musculoskeletal research that has the capability of transforming patient care,” Shuler said.

Along with Serrat and Shuler, the following students participated in the research:

  • Justin M. Godby, first-year medical studentHolly Tamski, Ph.D. student
  • Thomas J. Schlierf, fourth-year medical student
  • Laura M. Stanko, second-year medical student
  • Holly L. Tamski, biomedical sciences doctoral student

Morgan L. Efaw, former biomedical sciences student at Marshall, also was a member of the team.

Also presenting a poster at the ORS meeting is third-year medical student Alexander H. Slocum, Jr., Ph.D. who, along with collaborators from Massachusetts Institute of Technology, will showcase their findings, “Enhancing Orthopaedic Joint Lubrication using Synovial Fluid Impregnated Super-Wetting Porous Coatings,” an investigation reviewing ways of improving the use of prosthetic implants.

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Dr. Maria Serrat also was selected as the featured researcher in Marshall University’s School of Medicine Biomedical Sciences magazine, We Are…Bridging Medicine and Science.

Brain Expo returns Friday

More than 630 elementary school children from around the Tri-state region will visit the Memorial Student Center Friday to participate in activities designed to help them learn about the brain and nervous system.

The sixth Brain Expo at Marshall will feature more than 25 interactive stations where children will explore how the various parts of their nervous system are responsible for how their bodies function and learn how healthy lifestyle choices lead to better brain health. brain expo picture of brainActivities will include testing their reflexes, playing memory games, coloring their own “brain hats” and building brain cell-shaped key chains.

More than 200 Marshall students and faculty from the  College of Science and Psychology Department, as well as the Department of Neuroscience at the Joan C. Edwards School of Medicine, will oversee the activities. The St. Mary’s Medical Center also will be on hand with a station about brain and spinal cord safety.

The event is part of Brain Awareness Week, an annual global effort founded in 1996 by the Dana Alliance for Brain Initiatives. The Brain Expo at Marshall was founded by Dr. Nadja Spitzer and Dr. Brian Antonsen, both of whom are neuroscientists and assistant professors in the Department of Biological Sciences.

“Events like the Brain Expo are an excellent way to increase public awareness of brain research at Marshall and gain the interest of students who may choose a career path in science, technology, engineering or mathematics,” said Spitzer, the program director. “People are fascinated by the brain and there are many fun hands-on activities, like optical illusions, that show how the nervous system works. Our goal is to interest children in science and research at a young age by using games and activities that demonstrate the relevance of neuroscience in everyday life.”

Spitzer said registration for this year’s event is full, but anyone interested in next year’s program can e-mail brainawareness@marshall.edu.

For more information about the Brain Expo and Marshall’s Brain Awareness Program, visitwww.marshall.edu/baw.

The Brain Expo is supported by the National Science Foundation (Cooperative Agreement Award number EPS-1003907) and the College of Science, Department of Biological Sciences, Cell Differentiation and Development Center, and the Joan C. Edwards School of Medicine’s Biomedical Sciences Graduate Program.

This story was taken directly from: http://www.marshall.edu/wamnewsletter/2014/02/25/brain-expo-returns-friday/.

WV Undergraduate Research Day at the Capitol 2014

Image for WVURD14

Following the poster presentations, a luncheon was held to honor the student researchers, their mentors, and to formally recognize the winners of grants awarded by The Higher Education Policy Commission’s (HEPC) Division of Science and Research.

The luncheon was sponsored by the WV HEPC Division of Science and Research; Expansion of STEM Doctoral Education Program, Marshall University; Marshall Health; and WVU’s Office of Graduate Education and Life.

Norton_WVURD_grant'14One of the award recipients is one of Marshall’s own, Dr. Michael Norton. Norton received a Summer Undergraduate Research Experience (SURE) Grant for $210,000.

Congratulations!

 

 

MU biomedical students showcase research

BILL ROSENBERGER
The Herald-Dispatch

HUNTINGTON — Medical research that has an opportunity to affect the health and well-being of the general population should be celebrated, which is one of the reasons for the showcase at Pullman Plaza Hotel.

More than a dozen projects by Marshall University biomedical science graduate students and faculty members showcased their work as part of the ninth annual Biomedical Sciences Retreat. The event gives graduate students in the university’s biomedical sciences program an opportunity to share their research, including projects to study the effects of drugs on the kidney, obesity and type 2 diabetes, and how neurons respond to different patterns of neural activity.

Elsa Mangiarua, a professor in the Department of Pharmacology, Physiology and Toxicology, said Ph.D. students get to share their work with each other, while newly admitted Ph.D. students get to see some of the research they will be getting into.

“There are a lot of good projects with positive results in translational research,” said Rachel Murphy, who is a first-year student from Kansas. “It sets the bar high to help medical science advance to the next step. It’s definitely inspiring.”

Marcus_Terneus2013That was also the observation from Marcus Terneus, senior manager of global EH&S occupational toxicology at Mylan Pharmaceuticals. He is a 2006 graduate of the Marshall Ph.D. program and served as the afternoon’s keynote speaker.

“I’m very proud. It’s exciting to see the growth and what projects are going on,” Terneus said. “I keep close eyes on what students are doing.”

He also told the group that the education and research opportunities he received prepared him for what he’s seen during the past seven years.

“It’s given me what I needed to succeed,” he said.

The research also was noted as impressive because of how groundbreaking the results could be. Second-year student Justin Tomblin’s project centered on the link between obesity and breast cancer and how to block the growth of abnormal tissue.

In West Virginia, which has high obesity rates, that kind of research could help quite a few folks, he said.

“It definitely feels like you are doing something that may help friends or relatives,” Tomblin said.

John Maher, the vice president for research at Marshall and executive director of the Marshall University Research Corporation, said after hearing some presentations that Marshall has a very strong biomedical sciences program. He also noted that they are working on relevant and important problems pertaining to regional health care.

WV-INBRE summer research program wraps up with annual symposium

Undergraduate college students, the majority from West Virginia, showcased their summer research projects at Marshall University in July as part of the 12th Annual West Virginia IDeA Network for Biomedical Research (WV-INBRE) Summer Research Symposium.  MU INBRE and SRIMS Group Photo 2013The projects, which were researched under the direction of faculty mentors during an intensive 9-week period, included studies on the treatment of chronic low back pain, treatment and prevention of obesity, the pathophysiology of infectious diseases, the harmful effects of diabetes on brain and cardiac function among others.

WV-INBRE, which is designed to support biomedical research in the state, is supported by a grant from the National Institutes of Health (NIH) to Marshall University, in cooperation with West Virginia University and eleven other colleges and universities in the state.  The program allows students at undergraduate institutions research opportunities in labs at both Marshall and WVU.  In addition to the formal research Brandon Kirby, WV-INBRE intern from Bluefield State Collegetraining they receive, students attended workshops and seminars aimed at helping them understand the research process and graduate education.

This year’s summer research symposium featured keynote speaker, Brad Goodner, Ph.D., professor of Biology at Hiram College in Ohio.

Students in this year’s WV-INBRE program at Marshall University included Jaya Ale, University of Charleston; Joshua Easterling, University of Charleston; Bishnu Kafley, Berea College; Rebecca Martin, Davis and Elkins College; Hajer Mazagri, University of Charleston; Noah Mitchell, Bluefield State College;  Rishi Reddy, West Virginia State University; Anthony Schnelle, Wheeling Jesuit University; and Linh Vu, University of Charleston.

Annesha_King and Dr. Koc_3Also participating in this year’s symposium where three students with the university’s Summer Research Internship for Minority Students (SRIMS) who worked closely with WV-INBRE interns.  They included Emmanuel “Manny” Rosas, University of Texas at Brownsville, Annesha King, University of the Virgin Islands and Ashlea Hendrickson, Oakwood University.

In addition to the participants listed above, students and faculty associated with WV-INBRE through other programs were selected to present their research findings in an oral presentation.  They are:

  • Jessica Allen, Concord University
  • Cara Halldin, Ph.D., an alumnus of the WV-INBRE program and currently an epidemiologist with the Centers for the Disease Control and PreventionMahavadi_2013
  • Kathy Loughman, John Marshall High School (WV-INBRE high school component)
  • Rebecca Martin, Davis & Elkins College
  • Sricharan Mahavadi, Shepherd University
  • Jennifer Franko, Ph.D., Biology Department, Bethany College

Applications for next year’s WV-INBRE internship will be available after January 1 at http://www.wv-inbre.net/.

Students interested in applying to the SRIMS program may find the application information at http://www.marshall.edu/wpmu/bms/future-students/summer-research-internship/.

Marshall hosting students from eight institutions for biomedical research internships

Ashlea and Dr. YuHUNTINGTON, W.Va. – Twelve undergraduate students from eight institutions are spending their summer doing biomedical research in Marshall University’s laboratories. The students are participating in nine-week programs sponsored by the West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) and the university’s Summer Research Internship for Minority Students (SRIMS) program.

Dr. Elsa I. Mangiarua, a professor in the Department of Pharmacology, Physiology and Toxicology at Marshall’s Joan C. Edwards School of Medicine, directs the WV-INBRE summer program. She said both programs give participants the opportunity to do meaningful research and much more.

“Over the summer, these students will gain valuable, hands-on experience doing graduate-level research in the labs of some of Marshall’s finest scientists,” she said. “We also teach them how to share their findings at a scientific meeting and to network, all of which helps them build academic competitiveness for graduate school.”

Diana R. Maue, who coordinates the SRIMS program, agreed, adding, “It’s exciting that we are able to provide these in-depth, mentored research opportunities for very talented undergraduates, and it’s equally important that these programs promote awareness of graduate degree programs and careers in biomedical research. We are helping to develop a pipeline for training tomorrow’s scientists.”

Manny (front) and Hajer (back)While at Marshall, the interns are working in state-of-the-art facilities on research projects related to cancer, cardiovascular disease, obesity and diabetes, neuroscience, toxicology and environmental health, infectious diseases and bioinformatics. The students will present their research results at a symposium on July 29 at the university’s Memorial Student Center.

In addition to the formal research training they each receive from their Marshall faculty mentors, the interns are taking part in workshops and seminars about a variety of topics related to research and graduate education. Students in the two programs attend many of the same seminars and interact socially through a bowling outing, ice cream socials and other special events intended to help them get to know one another outside of the laboratory environment. 

Students participating in the WV-INBRE summer program include: 

  • Jaya Ale, University of Charleston (Dr. Eric Blough, mentor)
  • Joshua Easterling, University of Charleston (Dr. Elaine Hardman, mentor)
  • Bishnu Kafley, Berea College (Dr. Travis Salisbury and Dr. Jim Denvir, mentors)
  • Rebecca Martin, Davis and Elkins College (Dr. Piyali Dasgupta, mentor)
  • Hajer Mazagri, University of Charleston (Dr. Richard Egleton, mentor)
  • Noah Mitchell, Bluefield State College (Dr. Nalini Santanam, mentor)
  • Rishi Reddy, West Virginia State University (Dr. Larry Grover, mentor)
  • Anthony Schnelle, Wheeling Jesuit University (Dr. Monica Valentovic, mentor)
  • Linh Vu, University of Charleston (Dr. Gary Rankin, mentor)

The WV-INBRE program also sponsors summer fellowships for instructors. This year’s fellowship recipients are science teacher Olivia Boskovic of Huntington High School and Dr. Sobha Goraguntula, an assistant professor of chemistry at Alderson-Broaddus College. Boskovic is working in the lab of Dr. Emine Koc. Goraguntula’s mentor is Dr. Travis Salisbury.

WV-INBRE is funded through a $16 million grant from the National Institutes of Health. Marshall—in partnership with researchers at West Virginia University—received the award to help build expertise in biomedical research. 

Students in this year’s SRIMS program are:

  • Annesha King, University of the Virgin Islands (Dr. Emine Koc, mentor)
  • Ashlea Hendrickson, Oakwood University (Dr. Hongwei Yu, mentor)
  • Emmanuel Rosas, University of Texas at Brownsville (Dr. Richard Egleton, mentor)

Support for the SRIMS program comes from the university’s Joan C. Edwards School of Medicine Biomedical Sciences Graduate Program and the West Virginia Higher Education Policy Commission’s Division of Science and Research.

Each student receives a stipend. Depending on the program in which they are participating, they may also receive room and board, lab fees, and reimbursement for travel to and from Marshall.

For more information about the WV-INBRE program, visit www.wv-inbre.org or contact Mangiarua at mangiaru@marshall.edu or 304-696-6211. For more information about the SRIMS program, visit www.marshall.edu/bms/future-students/summer-research-internship or contact Maue at maue1@marshall.edu or 304-696-3365.

 

Marshall Biomedical Sciences Graduate Program is well represented at Experimental Biology Meeting

Allison, Miranda, Kristeena

BMS Ph.D. students, Allison, Miranda, and Kristeena, take a time out from research to enjoy a Boston Red Sox game!

Marshall University’s Biomedical Sciences (BMS) Graduate Program was well represented at the Experimental Biology Meeting that recently took place in Boston, MA. The annual national meeting involves over 14,000 scientists and exhibitors representing fields of study ranging from anatomy, physiology, pathology, and biochemistry to epigenetics, nutrition, cancer biology, and pharmacology. Some Marshall School of Medicine faculty and students were invited to give oral presentations of their research, while others were able to present their research during the poster sessions. The list of attendees is given below.

Oral presentations by:

Piyali Dasgupta, Ph.D.

Piyali Dasgupta, Ph.D. -
Invited speaker for special session “Molecular Biology of Lung Malignancy” – Title: “Nicotine increases the expression of alpha7-nicotinic receptors (alpha7-nAChRs) in human squamous cell lung cancer cells via Sp1/GATA pathway”

 

 

W. Elaine Hardman, Ph.D.W. Elaine Hardman, Ph.D. – Invited speaker for special session “What Comes First: The Food or the Nutrient?” – Title: “Whole foods or their bioactive components? Potential of walnuts in cancer prevention and treatment.” 

 

 

Maria Serrat, Ph.D.

Maria Serrat, Ph.D. – Invited speaker for special session “Bone Physiology under Environmental Stress” – Title: “Temperature effects on the growth plate and its vasculature”

 

 

 

Allison Wolf, Ph.D. CandidateM. Allison Wolf, BMS Ph.D. Candidate – Invited speaker for special session – Title: “Benzyl isothiocyanate enhances chemosensitivity and inhibits migration and invasion of head and neck squamous cell carcinoma”

 

 

 

 

Katie_Brown_EB

Katie Brown, M.S. – Invited speaker for special session “Molecular Biology of Lung Malignancy” – Title: “Inhibition of cholinergic signaling causes apoptosis in human bronchioalveloar carcinoma”

 

 

Ron, Miranda, Allison, Johannes, Kristeena_EB

Poster presentations by:
Miranda Carper, BMS Ph.D. Candidate
Johannes Fahrmann, BMS Ph.D. Candidate Christopher McNees, MU student 
Rounake Nande, BMS Ph.D. Student
Chris Racine, BMS Ph.D. Student
Kristeena Ray, BMS Ph.D. Student
Cody Stover, MU student
Brent Thornhill, MU graduate
Monica Valentovic, Ph.D., Toxicology and Environmental Health Sciences’ Research Cluster Coordinator
Gary Rankin, Ph.D., Toxicology and Environmental Health Sciences’ 
Research Cluster

Dr. Maria Serrat, Assistant Professor in the Department of Anatomy and Pathology and researcher within the Neuroscience and Developmental Biology Research Cluster, had the opportunity to give an oral presentation as well as participate in a focus group that evaluated anatomy education material for a publisher. 

Johannes at Poster

Serrat said she was happy to see Marshall well represented at the meeting and that “the large number of Marshall attendees says a lot about the expanding research emphasis of our institution.”

Kristeena at Poster

Carper at Poster

 

 

Marshall’s BMS students recognized at the national level

Marshall’s BMS students recognized on a NATIONAL level for their recent Young Adult Science Café! The American Society for Biochemistry and Molecular Biology posted a press release on their Public Outreach website. Check it out: www.asbmb.org/PublicOutreach/Templates/PubOutreachDefault.aspx?id=40020

Funding for collaborative medical research announced at Marshall University

Translational research aims to transfer discoveries from the laboratory to the bedside quickly

Wednesday, Feb. 27, 2013

HUNTINGTON, W.Va. – Marshall University Joan C. Edwards School of Medicine officials today announced $150,000 in funding for six research grants associated with the school’s translational medicine research program.

The Marshall Health Translational Pilot Grant program, created in 2012, encourages collaborative research between basic scientists and clinical physicians in an effort to speed up the process of laboratory discovery to clinical application for patients.  The grants are funded by Marshall Health.

“We are very pleased that Marshall Health has created this grant program to stimulate research efforts,” said Richard M. Niles, Ph.D., senior associate dean for Biomedical Sciences at the School of Medicine. “Moving Marshall to the next level of medical research takes vision, commitment and of course, funding.  This grant allows 12 researchers, as well as medical residents and students, the opportunity to explore very diverse areas.”

Marshall Health is the faculty practice plan for the Joan C. Edwards School of Medicine and supports the clinical, educational, research and services missions of the school.  Beth Hammers, executive director of the organization, says the pilot grant program provides one year of support at $25,000 for each grantee, with additional funding based on progress of the research.

“Medical research is essential to the development of new medical treatments and cures for patients,” Hammers said.  “We are thrilled to help stimulate a robust, viable grant program which pairs basic scientists from Marshall University with School of Medicine physicians to work on projects which will lead to the betterment of our community.”

The investigators and their projects are listed below:

Dr. Pier Paolo Claudio, Department of Biochemistry and Microbiology, and Dr. Anthony Alberico, Department of Neuroscience – “Chemotherapy resistance and sensitivity testing in tumors of the central nervous system”

Dr. Elaine Hardman, Department of Biochemistry and Microbiology, and Dr. James Jensen, Department of Surgery – “Feasibility and Safety of Nutritional Supplementation with Omega-3 Fatty Acids to Reduce Prostate Specific Antigen Rise in Men with Biochemical Failure after Prostatectomy or External-Beam Radiotherapy”

Dr. Nalini Santanam, Department of Pharmacology, Physiology and Toxicology, and Dr. Paulette Wehner, Department of Cardiology – “Perivascular Fat Relation to Hypertension—Appalachian Heart Study”

Dr. Nalini Santanam, Department of Pharmacology, Physiology and Toxicology, and Dr. Abid Yaqub, Department of Medicine, Endocrinology Section – “Impact of Technology-based Behavioral Intervention on Molecular and Clinical Parameters in Patients with Type 2 Diabetes”

Dr. Monica Valentovic, Department of Pharmacology, Physiology and Toxicology, and Dr. Brenda Dawley, Department of Obstetrics and Gynecology – “Prenatal Exposure to Heavy Metals and Polycyclic Aromatic Hydrocarbons (PAH) Alter Umbilical Cord Blood Levels of Thyroid Hormone and Vitamin D”

Dr. Hongwei Yu, Department of Biochemistry and Microbiology, and Dr. Yoram Elitser, Department of Pediatrics – “Investigate the distribution of segmented filamentous bacteria (SFB) in American children and the presence of SFB with childhood diseases”

Other current translational research under way at the Marshall University Joan C. Edwards School of Medicine includes a partnership with the University of Kentucky (UK) as part of the National Institutes of Health’s Clinical and Translational Science Awards program, which also is aimed at speeding the time for laboratory discoveries to benefit patients.

In 2011, UK and its partners received $20 million for the program to support research at UK’s Center for Clinical and Translational Science, making Marshall part of a select national biomedical research network.


Contact:  Ginny Painter, Communications Director, Marshall University Research Corporation, 304.746.1964, or Leah C. Payne, Director of Public Affairs, Schools of Medicine and Pharmacy, 304-691-1713

BMS Graduate Student Organization participates in the Jared Box Project

by Saeed Keshavarzian, keshava1@live.marshall.edu

BMS students from left: Brad, Bill, Holly, Miranda, Allison, Johannes, and Saeed

As the holiday season approaches, we are reminded to think about others outside of our busy lives. This year, the Biomedical Sciences (BMS) Graduate Student Organization (GSO) would like to share with you Jared’s story. He was a special five-year-old boy who, in 1999, was diagnosed with an incurable brainstem tumor; he unfortunately lost his battle with cancer in November 2000. In his short time on Earth, Jared went from doctor appointment to doctor appointment and always carried a backpack filled with his favorite toys and games. Those toys and games brought Jared such joy that, for a brief moment, he was not thinking about his illness, but was just being a child captivated in play.

This is the second year the BMS GSO has participated in the Jared Box Project, an endeavor to share the same joy and relief that toys brought to Jared with other children suffering similar childhood illnesses. Allison Wolf, GSO President and a BMS Ph.D. candidate, along with other BMS students organized the toy drive and a bake sale to contribute to filling Jared boxes.

Miranda and Allison, all smiles, with the toys for the children at Cabell Huntington Hospital

The GSO members delivered the toys to children at Cabell Huntington Hospital and St. Mary’s Medical Center on Friday, December 7th.  Allison said, “We have a wonderful group of students and faculty in our program who make events, such as the Jared Box Project, a success.” Miranda Carper, BMS Ph.D. candidate agreed, and also said that, “this is the second year I have participated and the experience left me feeling happy, humbled, and heart-broken all at the same time. Seeing the children’s faces light up when I handed them a gift warmed my heart, but also left me feeling amazed by their strength and determination.” 

Johannes organizing presents for the children

GSO Vice President, Johannes Fahrmann, who helped organize the Jared Box Project for the second time said that “being a part of this project is a great feeling and instills a sense of unity amongst the organization and the community. It also highlights the warmth that people have in their hearts and highlights one of the main goals, in my opinion, of the GSO which is to give back to those less fortunate.”

For more information on the Jared Box Project, please visit this website: http://www.thejaredbox.com/.

Marshall biomedical sciences’ researchers publish e-book on nutrition and cancer

Cover of "Nutrition and Cancer: From Epidemiology to Biology"Researchers at Marshall University’s Joan C. Edwards School of Medicine have collaborated on an electronic book, “Nutrition and Cancer From Epidemiology to Biology,” recently published by Bentham Science Publishers.

This ebook is one of the latest efforts of researchers at the Marshall University Nutrition and Cancer Center.

A collection of scientific articles written by Marshall faculty members and students, the publication was edited by Dr. Richard M. Niles, professor and chairman of the university’s Department of Biochemistry and Microbiology, and Dr. Pier Paolo Claudio, associate professor in the Department of Biochemistry and Microbiology and director of the McKown Translational Genomic Research Institute.

According to the publisher, various estimates suggest that between 30-40% of all human cancers are related to dietary patterns. Strong epidemiological evidence from studies points to dietary constituents that either contribute or protect against the development of various forms of cancer.

This e-book reviews some traditional and relatively new areas of nutrition and cancer. Epidemiological data is combined with molecular biology research and, where available, clinical trial data. The emerging science of “Nutrigenomics” is discussed with chapters on the biological role of various nutrition components from red wine, peppers, green tea, fish oil, cruciferous vegetables, retinoids; and the intersection of nutrition and epigenetics in hematopoiesis.

The publication will be of interest to researchers in the nutrition and cancer fields, physicians in family and community medicine, internal medicine and oncology, and dieticians providing counseling to cancer patients and cancer survivors.

by Ginny Painter
Director of Communications
Marshall University Research Corporation 
ginny.painter@marshall.edu 
www.marshall.edu/murc  

 

You are invited to enjoy the fall 2012 issue of “We Are…Bridging Medicine and Science”

Marshall University’s Biomedical Sciences Graduate Program invites you to enjoy reading the Fall 2012 | Issue 2 of We Are…Bridging Medicine and Science!

Click the publication’s front cover below to link to the magazine: 

 

 

 

 


 

 

 

 

 

 

 

 

 

Drs. Claudio and Niles co-edit and publish an ebook on nutrition and cancer featuring BMS professors and students

Cover of "Nutrition and Cancer: From Epidemiology to Biology"Pier Paolo Claudio, M.D./Ph.D., and Richard M. Niles, Ph.D., of the Biomedical Sciences Graduate Program have co-edited and written articles in an ebook entitled “Nutrition and Cancer: From Epidemiology to Biology.” This ebook is one of the latest efforts of cancer researchers at the Marshall University Nutrition and Cancer Center, where the role of nutrition in cancer is actively and successfully investigated. The ebook contains a collection of scientific articles, written by researchers and students in the Marshall University Biomedical Sciences Graduate Program.  

The purpose of this publication is to educate and inform the public regarding the latest knowledge on nutrition and cancer. It focuses on the role of various nutritional components in cancer prevention, as well their present and future use in cancer therapy. According to Dr. Pier Paolo Claudio, “This e-book will be of interest to researchers in the nutrition and cancer field, physicians in family and community medicine, internal medicine and oncology, as well as dieticians providing counseling to cancer patients and cancer survivors.”

Dr. Niles says that the best description of the importance of this book can be found within the foreword, written by Dr. Gary Meadows of Washington State University:

“While we as individuals cannot modify our genetic makeup and may have little control over the multitude of carcinogens in our environment, we have the power to make healthy diet-based choices that can significantly modify cancer risk and progression. The authors have structured this book not only to review the epidemiological studies that support the roles of selected nutrients/phytochemicals in cancer control, but also they review the cellular and molecular pathways involved in their action as well as the clinical data related to their efficacy in cancer treatment. Consequently, this book has wide appeal not only to researchers in the nutrition and cancer field, but also to oncology practitioners, dieticians, as well as cancer survivors, who are interested learning how healthy dietary choices can enhance their quality of life.” 

According to Dr. Niles, editing the book involved reviewing each chapter and making suggestions for improvement of the content handwriting. He also co-wrote a chapter with Dr. Rankin on resveratrol, found in high concentration in red wine, and its ability to inhibit the development or progression of certain types of cancer. Dr. Claudio co-wrote an article with Ph.D. candidate M. Allison Wolf on isothiocyanates, phytochemicals found in cruciferous vegetables, which his lab found to target carcinogenesis during tumor initiation, promotion, and progression.

The following authors and articles are found within the ebook:

Richard M. Niles, Ph.D. and Gary O. Rankin, Ph.D.
Resveratrol, A Phytoalexin with a Multitude of Anti-Cancer Activities

Jamie K. Lau, Kathleen C. Brown, Aaron M. Dom and Piyali Dasgupta, Ph.D.
Capsaicin: Potential Applications in Cancer Therapy

W. Elaine Hardman, Ph.D.
Omega-3 Fatty Acids as an Adjuvant to Cancer Therapy

Richard Egleton, Ph.D.
Green Tea Catechins and Cancer

Kinsley Kelley Kiningham, Ph.D., and Anne Silvis
Receptor Independent Effects of Retinoids

Vincent E. Sollars, Ph.D.
Epigenetics as a Mechanism for Dietary Fatty Acids to Affect Hematopoietic Stem/Progenitor Cells And Leukemia – Royal Jelly for the Blood

Monica Valentovic, Ph.D. and Nalini Santanam, Ph.D./M.P.H.
Nutrition, Oxidative Stress and Cancer

John Wilkinson IV, Ph.D.
Is there an Etiologic Role for Dietary Iron and Red Meat in Breast Cancer Development?

M. Allison Wolf and Pier Paolo Claudio, M.D./Ph.D.
Isothiocyanates Target Carcinogenesis During Tumor Initiation, Promotion and Progression

The ebook can be ordered directly online through the Bentham Science website at the following link: http://198.247.95.142/ebooks/9781608054473/index.htm

First Annual Appalachian Regional Cell Conference to be held in October

Appalachian Regional Cell Conference Posterby Allison Wolf

A collaborative effort between students at Marshall University, WVU, UK and OU has led to the organization of the first annual Appalachian Regional Cell Conference (ARCC). The goal of this scientific symposium is to foster interaction and future collaboration among students. Miranda Carper, former President of the GSO, calls the event a “a dynamic and interactive opportunity for research students to present their work to their peers.” The conference will host poster and oral presentations.

The event will be held on October 12, 2012 at the Charleston Area Medical Center in Charleston, WV. A grant received from the American Society for Cell Biology will provide the funding.

Dr. Vinay Pathak, who has worked with the National Cancer Institute since 1999 as a Senior Investigator, will deliver the keynote speech. Dr. Pathak’s lab focuses mostly on research projects relating to HIV drug resistance.

According to Graduate Student Organization (GSO) Vice President, Johannes Fahrmann, “one of the biggest advantages to a student run conference is the fact that it takes out some of the intimidation factor that may be involved with a larger scale meeting that is run by mostly established individuals.” GSO secretary Ben Owen adds that, “because this meeting is a smaller conference, as compared to national conferences sponsored by societies, students will have a better chance of networking with others in a more relaxed atmosphere.”

If you would like to receive an application, or have any questions about the ARCC conference, please contact Allison Wolf (teter6@marshall.edu).

Dr. Marcia A. Harrison publishes a book chapter

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Marcia A. Harrison, Ph.D.Marcia A. Harrison, Ph.D., recently had a chapter published in a 2012 release by Springer Science + Media. Dr. Harrison is a researcher within the Neuroscience and Developmental Biology research cluster in the Biomedical Sciences Graduate Program.

The book, published by Springer Science + Business Media, is entitled Phytohormones and Abiotic Stress Tolerance in Plants. This publication summarizes what is currently known regarding phytohormones, which are chemicals that regulate plant growth, and how they are influenced by the environmental stresses that plants encounter. Dr. Harrison penned Chapter 2, “Cross-Talk Between Phytohormone Signaling Pathways Under Both Optimal and Stressful Environmental Conditions.”

Dr. Harrison is a professor in the Department of Biological Sciences. Her research focuses on the role of the plant hormone ethylene in regulating plant growth and growth movements. Ethylene often acts as a signal that triggers growth changes in response to changing environmental conditions.

Excellent work, Dr. Harrison!To learn more and to download the book, visit Springer’s website: http://www.springer.com/life+sciences/plant+sciences/book/978-3-642-25828-2.

Dr. Georgel presents at international scientific conference

Philippe Georgel, Ph.D.

Dr. Philippe Georgel recently traveled to San Antonio to present his research at the 20th International Analytical Ultracentrifugation Conference.

The following Marshall University press release highlights Dr. Philippe Georgel’s recent participation in the 20th International Analytical Ultracentrifugation Conference. In addition to teaching Biological Sciences at the main Marshall campus, Dr. Georgel is an Associate Professor in the Department of Biochemistry and Molecular Biology in the Biomedical Sciences Graduate Program. Dr. Georgel researches in two research clusters: Cancer Biology and Neuroscience and Developmental Biology.


Huntington, W.Va.  – Dr. Philippe Georgel, a professor of biological sciences at Marshall University, recently traveled to San Antonio to present his research at the 20th International Analytical Ultracentrifugation Conference.

The biennial conference is focused on research done using a specific laboratory technique to characterize the size, shape and interactions of molecules and macromolecules in solutions. Analytical ultracentrifugation is widely used in molecular biology, biochemistry and polymer science.

Georgel studies the effects of chromatin—the combination of DNA and proteins that make up the contents of the nucleus of a cell—on nuclear functions. His conference presentation focused on his use of a new method called Quantitative Agarose Gel Electrophoresis, or QAGE. QAGE, allows for analysis of structure and composition of nucleo-protein complexes, and is complementary to the use of analytical ultracentrifugation.

The research Georgel presented was a collaborative effort among his group at Marshall; Dr. James Denvir, associate professor of biochemistry and microbiology at the university’s Joan C. Edwards School of Medicine; and Dr. Stuart Lindsay and Dr. Qiang Fu from Arizona State University.
Georgel has already been invited back to present at the 2014 conference, which will be held in Japan.

For more information, contact Georgel at georgel@marshall.edu or 304-696-3965.

Dr. Maria Serrat featured in the Neuron for MU-Advance fellowship

Maria Serrat, Ph.D.Dr. Maria Serrat has been featured in the Spring 2012 issue of the Neuron, the West Virginia Journal of Science and Research. She was featured for being named one of this year’s faculty fellows and mini-grant recipients by MU-ADVANCE. Dr. Serrat is an Assistant Professor in the Department of Anatomy and Physiology and studies the impact of environmental factors on bone elongation through real-time imaging.

The Neuron is a quarterly journal of science and research that contains features about research, researchers, and science-related news from West Virginia.

MU-ADVANCE, funded by the National Science Foundation (NSF), seeks to support the research and professional development of female faculty in STEM disciplines (science, technology, engineering and mathematics).

To read the story (featured on page four of the issue), download the pdf of the Spring 2012 issue of the Neuron:
http://www.wvresearch.org/wp-content/uploads/2012/04/Spring-Neuron-2012.pdf.

To learn more about MU-ADVANCE, consult: http://www.marshall.edu/muadvance.

Graduate student Ben Owen to present at the National Student Research Forum

Benjamin Michael OwenBen Owen, a second-year student in the Biomedical Sciences M.S. program, has been selected to present a poster at the National Student Research Forum. The forum seeks to provide an opportunity for graduate students, medical students, interns, and residents conducting research in the biomedical sciences to assemble and receive recognition and feedback from established scientists. This event takes place yearly at the University of Texas Medical Branch campus in Galveston, TX and is planned and managed by students.

Ben’s project is entitled “Short-Term Activity-Dependent Changes in Axonal Function in Hippocampal CA3 Pyramidal Neurons.” The hippocampus is a region of the brain that is essential for normal memory function. Ben’s study examines how pyramidal neurons in the hippocampus function when they are activated at high frequencies (between 30 and 100 Hertz). This type of high-frequency activity in the neurons is common to normal processes, such as encoding and retrieving memory, as well as pathological processes, including seizures. Although scientists thoroughly understand how neurons create action potentials (the spike in electrical potential that is responsible for communication between neurons), little experimental attention has been given to how high frequency activation affects generation of action potentials. Ben researches within Dr. Larry Grover’s lab in the Robert C. Byrd Biotechnology Science Center.

Ben says that he is excited to have the chance to share his research with fellow students and scientists on the national level. Congratulations to Ben on being selected for this opportunity!

Dr. Maria Serrat awarded faculty fellowship and mini-grant by MU-ADVANCE

Maria Serrat, Ph.D.

The Biomedical Sciences Graduate Program at Marshall University’s Joan C. Edwards School of Medicine is proud to announce that Dr. Maria Serrat has been awarded an MU-ADVANCE fellowship and mini-grant. Dr. Serrat is an Assistant Professor in the Department of Anatomy and Physiology who researches within two biomedical science research clusters: Neuroscience and Developmental Biology and Toxicology and Environmental Health Science. The Marshall University news release below highlights Dr. Serrat and the other award winners. Congratulations, Dr. Serrat!


MU Press Release Contact: Ginny Painter, ginny.painter@marshall.edu

Marshall University’s MU-ADVANCE program has named four faculty fellows and awarded five mini-grants as part of the program to enhance the research and professional development of female faculty members in the fields of science, technology, engineering and mathematics.MU-ADVANCE is funded through a National Science Foundation (NSF) initiative called “Advancement of Women in Academic Science and Engineering Careers,” or ADVANCE for short. The national program supports projects, like the one at Marshall, to help institutions transform long-standing practices and academic climate that discourage women from pursuing careers in high-tech fields.

MU-ADVANCE faculty fellowships, intended for tenure-track faculty members, are awarded competitively based on a formal research proposal submitted by each applicant. Each of the four faculty fellows selected this year will receive $15,000 to be used for her research, and $5,000 for a senior research collaborator to help foster her professional development and success while preparing for tenure.

This year’s faculty fellows include Dr. Kristi Fondren, assistant professor in the Department of Sociology, who uses the Appalachian Trail and its hikers to analyze how humans develop relationships with the environment; Dr. Hyoil Han, associate professor in the Department of Computer Science, who is working to develop a system to help biomedical researchers quickly access evidence-based literature regarding breast cancer; Dr. Elizabeth Niese, assistant professor in the Department of Mathematics, who will use her award to further her work in algebraic combinatorics and to provide research opportunities for math students at Marshall; and Dr. Maria Serrat, assistant professor in the Department of Anatomy and Pathology, whose research uses real-time imaging to determine the impact of environmental factors like nutrition, temperature and physical activity on bone elongation.

Serrat said, “The MU-ADVANCE fellowships allowed me to establish and maintain a formal collaboration with a senior faculty mentor from Cornell University, whose expertise in biophysical imaging was critical to the progression of my microscopy research here at Marshall.”

For Serrat, this newest grant is a continuation of the faculty fellowship award she received last year. She is also one of five MU-ADVANCE mini-grant recipients this year.

The mini-grants are awarded in amounts up to $1,000, and fund tuition for professional development courses, registration and travel expenses for national meetings, development of grant proposals, interdisciplinary research efforts and manuscript preparation.

All five of this year’s mini-grant recipients are assistant professors at Marshall and, in addition to Serrat, include Dr. April Fugett-Fuller and Dr. Jennifer Tiano of the Department of Psychology, Dr. Anna Mummert of the Department of Mathematics, and Dr. Bin Wang of the Department of Chemistry.

“The best thing about the fellowships and mini-grants, in addition to the research funding, is that they provide a structure for outlining your professional goals and a means for documenting when and how you will achieve them,” added Serrat. “MU-ADVANCE recognizes that it is hard being a new assistant professor, and their funding opportunities have been invaluable to my professional development by helping me articulate and carry out a research plan alongside my teaching and service commitments.”

According to Dr. Marcia A. Harrison, professor of biological sciences at Marshall and the principal investigator on the MU-ADVANCE grant from NSF, the fellowships and mini-grants complement the recruitment, retention and policy efforts undertaken at the university over the past five years as part of the program.

“MU-ADVANCE’s support of networking has been crucial in enhancing faculty career development,” Harrison said. “The fellowships and mini-grants provide networking opportunities by funding travel to professional conferences and workshops, and laboratory visits to connect faculty members with other professionals worldwide.

“The program also sponsors campus networking events to foster collegiality and collaborations at Marshall, and has brought in experts to teach faculty critical career advancement skills like writing, delegation and time management.”

According to the NSF, women continue to be significantly underrepresented in almost all science and engineering fields. In fact, although 41 percent of all faculty members at Marshall are women, only 27 percent of science, technology, engineering and mathematics faculty members are female.

Research indicates that the lack of women’s full participation in science and engineering academic careers is unrelated to their ability, interest and technical skills, but is more often a systemic consequence of the culture and organizational structure at institutions of higher education. Difficulty balancing work and family demands also plays a key role.

The MU-ADVANCE program was established in 2006 with a $1.2 million NSF grant. In 2009, Marshall’s program was awarded funding for an additional two years, funded in part through the American Recovery and Reinvestment Act.

For more information about MU-ADVANCE, contact Harrison at harrison@marshall.edu or visit www.marshall.edu/mu-advance.

BMS graduate student Ben Owen debriefs on National Student Research Forum

Ben Owen, Ph.D. candidateA few months ago, we announced that Ben Owen, a BMS graduate student, would be attending the National Student Research Forum in Galveston, Texas. Ben has since attended and returned from this event, and I sat down with him recently to discuss his experience. 

This was Ben’s first time presenting outside of Marshall, and he feels that it was a great experience. His greatest hope for this conference was to get a sense of what to expect at the Society for Neuroscience National Meeting, taking place in November. As described in the last article, the National Student Research Forum provides an opportunity for graduate students, medical students, interns, and residents conducting research in the biomedical sciences to assemble and receive recognition and feedback from established scientists. This event takes place yearly at the University of Texas Medical Branch campus in Galveston, TX and is planned and managed by students. 

While at the conference, Ben met a lot of other presenters, who he was surprised to find were mostly medical students. In addition to being able to mingle and discuss their projects, they were able to have a bit of free time fun as well. About sixty students were in attendance by Ben’s count. He says that he would recommend the conference highly, especially to medical students. To him, the forum has many benefits to graduate and medical students alike. It’s not a lengthy event that takes a lot out of one’s work time, it’s small and somewhat laidback, and it offers an opportunity to discuss one’s research with people who are studying very similar topics. For example, Ben was able to interact with researchers studying the hippocampus, and he was able to recommend Dr. Egleton’s work to a student researching the blood brain barrier. Mostly, the event offers an opportunity to break through one’s first-time anxiety at a smaller conference and prepare for the larger events in one’s area of research.

Ben’s project is entitled “Short-Term Activity-Dependent Changes in Axonal Function in Hippocampal CA3 Pyramidal Neurons,” and he researches in Dr. Larry Grover’s lab. To learn more about Dr. Grover’s research and his lab, navigate to his faculty page.

Dr. Sollars and Jasjeet Bhullar to be published in Immunogenetics

A paper by Dr. Vincent Sollars and Ph.D. candidate Jasjeet Bullar of the Biomedical Sciences Graduate Program will be published in an upcoming edition of Immunogenetics. This journal spotlights research concerning the genetic control of the immune system, including immune response and susceptibility to disease. More about the journal can be found at the Immunogenetics website.

The paper is entitled “YB-1 expression and function in early hematopoiesis.” YB-1 is a gene that encodes for a “cold shock” protein that is a part of the stress response system. It is expressed broadly during development and serves as a cell survival factor, regulating the transcription and/or translation of numerous genes controlling cellular growth and death. According to their research, YB-1 is already known to be involved in the progression of cancers, and he is investigating its possible role in leukemia. His research specifically focuses on the characterization of the expression pattern and role of the YB-1 gene in early hematopoiesis and leukemia. YB-1 and Hsp90, another gene studied by Dr. Sollars, comprise a new arena of cancer therapeutic targets that offer aJasjeet Bhullar, Ph.D. candidate lot of promise. Jasjeet Bhullar was the primary author of the paper.

To learn more about the exciting biomedical research being performed by Dr. Sollars and other professors at the Marshall University Biomedical Sciences Graduate Program and the Joan C. Edwards School of Medicine, please visit the Marshall University Nutrition and Cancer Center website.