Department: Anatomy and Pathology
Research Cluster: Cancer Biology
Office: BBSC 336-V
Phone: (304) 696-3700
Dr. Emine Koc Associate Professor, Biochemistry and Microbiology
Dr. Koc’s multidisciplinary research takes advantage of biochemical, molecular and cell biological, and mass spectrometry-based proteomics technologies. Using this “systems biology” approach, her laboratory has paved the way to study mitochondrial translation by identifying all the protein components of the ribosome and translation initiation factor 3 (mtIF3) in mammalian mitochondria. More recently, they have determined the modification of MRPs by phosphorylation and acetylation at steady-state levels using mass spectrometry-based proteomics. Based on these observations, they have postulated that the mitochondrial translation machinery is regulated by post-translational modifications (PTMs) as NAD+ and ATP levels regulate the activities of many other mitochondrial enzymes involved in oxidative phosphorylation.
Dr. Koc’s current research interests are all integrative and are aimed at determining how components of mitochondrial translation/ribosomes affect oxidative phosphorylation and apoptosis in normal and disease conditions. As her research unveils more about the regulatory roles of MRPs and their PTMs, new strategies will be devised to manipulate mitochondrial function/dysfunction in metabolic diseases, cancer, and aging.
In Fall 2012, Dr. Koc will team-teach Molecular Basis of Medicine and Foundations of Biomedical Science.
Dr. Koc serves as an ad hoc grant reviewer for the National Institutes of Health, the National Science Foundation, and the U.S. Army Research Office. She also serves as a manuscript reviewer for several journals, including Biochemistry, the EMBO Journal (European Molecular Biology Organization), EMBO Reports, Experimental Cell Research, Human Molecular Genetics, Mitochondrion, PLoS (Public Library of Science) Biology, Plant Biology, Plant Cell, and Plant Physiology.
Dr. Koc is a member of the American Association for the Advancement of Science, the American Society for Biochemistry and Molecular Biology, the American Society for Mass Spectrometry, and the United Mitochondrial Disease Foundation.
Telephone: (304) 696-3680