Philippe Georgel, Ph.D., a professor in Marshall’s Biomedical Sciences Graduate Program Cancer Biology Research Cluster, was invited to speak at the recent Asilomar Chromatin and Chromosomes Conference, which was held on December 16th in Pacific Grove, CA. He presented entirely new research, for which he designed most of the experimental procedure, and was performed by Dr. Ata Abbas, a postdoctoral fellow in his laboratory.
The study reports the positive effect of omega-3 fatty acid treatment on various breast cancer cell lines. The omega-3 treatment modified the profile of expression of Human Leukocyte Antigen G (HLA-G), a molecule important in the immune evasion properties displayed by numerous types of cancerous cells. The treated cells display an HLA-G expression profile that resembles that of normal epithelial breast cells as well as a reduced ability to migrate (a property that can be indicative of lower metastatic abilities).
When asked what this research means to “non-scientists,” Georgel good-naturedly responded, “Our research is one additional piece of evidence to support the role of diet in preventing and/or helping find a cure for breast cancer (as well as other cancer types). An increase in omega-3 fatty acid (FA) in our regular diet can be easily achieved by substituting corn oil (rich in omega-6 FA and poor in omega-3 FA) with canola oil (rich in omega-3 FA and low in omega-6 FA), and also by eating more fish (omega-3-FA-rich).”
This project will be expanded to include the analysis of HLA-G expression profile in tissues from breast cancer patients’ biopsies and a small scale clinical trial involving daily consumption of omega-3 fatty acids (in collaboration with Dr. Rajesh Sehgal, Medical Oncologist at the Edwards Comprehensive Cancer Center). The results will be used as preliminary material for a submission to the National Institutes of Health and/or the Department of Defense.