Drs. Claudio and Niles co-edit and publish an ebook on nutrition and cancer featuring BMS professors and students

Cover of "Nutrition and Cancer: From Epidemiology to Biology"Pier Paolo Claudio, M.D./Ph.D., and Richard M. Niles, Ph.D., of the Biomedical Sciences Graduate Program have co-edited and written articles in an ebook entitled “Nutrition and Cancer: From Epidemiology to Biology.” This ebook is one of the latest efforts of cancer researchers at the Marshall University Nutrition and Cancer Center, where the role of nutrition in cancer is actively and successfully investigated. The ebook contains a collection of scientific articles, written by researchers and students in the Marshall University Biomedical Sciences Graduate Program.  

The purpose of this publication is to educate and inform the public regarding the latest knowledge on nutrition and cancer. It focuses on the role of various nutritional components in cancer prevention, as well their present and future use in cancer therapy. According to Dr. Pier Paolo Claudio, “This e-book will be of interest to researchers in the nutrition and cancer field, physicians in family and community medicine, internal medicine and oncology, as well as dieticians providing counseling to cancer patients and cancer survivors.”

Dr. Niles says that the best description of the importance of this book can be found within the foreword, written by Dr. Gary Meadows of Washington State University:

“While we as individuals cannot modify our genetic makeup and may have little control over the multitude of carcinogens in our environment, we have the power to make healthy diet-based choices that can significantly modify cancer risk and progression. The authors have structured this book not only to review the epidemiological studies that support the roles of selected nutrients/phytochemicals in cancer control, but also they review the cellular and molecular pathways involved in their action as well as the clinical data related to their efficacy in cancer treatment. Consequently, this book has wide appeal not only to researchers in the nutrition and cancer field, but also to oncology practitioners, dieticians, as well as cancer survivors, who are interested learning how healthy dietary choices can enhance their quality of life.” 

According to Dr. Niles, editing the book involved reviewing each chapter and making suggestions for improvement of the content handwriting. He also co-wrote a chapter with Dr. Rankin on resveratrol, found in high concentration in red wine, and its ability to inhibit the development or progression of certain types of cancer. Dr. Claudio co-wrote an article with Ph.D. candidate M. Allison Wolf on isothiocyanates, phytochemicals found in cruciferous vegetables, which his lab found to target carcinogenesis during tumor initiation, promotion, and progression.

The following authors and articles are found within the ebook:

Richard M. Niles, Ph.D. and Gary O. Rankin, Ph.D.
Resveratrol, A Phytoalexin with a Multitude of Anti-Cancer Activities

Jamie K. Lau, Kathleen C. Brown, Aaron M. Dom and Piyali Dasgupta, Ph.D.
Capsaicin: Potential Applications in Cancer Therapy

W. Elaine Hardman, Ph.D.
Omega-3 Fatty Acids as an Adjuvant to Cancer Therapy

Richard Egleton, Ph.D.
Green Tea Catechins and Cancer

Kinsley Kelley Kiningham, Ph.D., and Anne Silvis
Receptor Independent Effects of Retinoids

Vincent E. Sollars, Ph.D.
Epigenetics as a Mechanism for Dietary Fatty Acids to Affect Hematopoietic Stem/Progenitor Cells And Leukemia – Royal Jelly for the Blood

Monica Valentovic, Ph.D. and Nalini Santanam, Ph.D./M.P.H.
Nutrition, Oxidative Stress and Cancer

John Wilkinson IV, Ph.D.
Is there an Etiologic Role for Dietary Iron and Red Meat in Breast Cancer Development?

M. Allison Wolf and Pier Paolo Claudio, M.D./Ph.D.
Isothiocyanates Target Carcinogenesis During Tumor Initiation, Promotion and Progression

The ebook can be ordered directly online through the Bentham Science website at the following link: http://198.247.95.142/ebooks/9781608054473/index.htm

Biomedical Sciences students recognized at international science meeting

M. Allison Wolf, Ph.D. candidateHUNTINGTON, W.Va. – Two Marshall University students received special recognition for their research at this year’s international Experimental Biology conference held April 21-25 in San Diego.
 
M. Allison Wolf, a biomedical sciences doctoral candidate from Parkersburg, received first place in her group in a poster competition held as part of the conference’s Diet and Cancer mini-symposium. The mini-symposium was funded by the American Society of Nutrition.
 
Wolf’s presentation focused on her research on the anticancer effects of isothiocyanates—a natural compound extracted from cruciferous vegetables—on head and neck cancer. Her work shows the compound both inhibits head and neck metastasis and greatly increases sensitivity to chemotherapy in therapy-resistant head and neck cancers. Wolf works in the lab of Dr. Pier Paolo Claudio, an associate professor in the Biomedical Sciences Graduate Program and the Departments of Biochemistry and Microbiology and Surgery at the university’s Joan C. Edwards School of Medicine.
 
Wolfe said she gained a great deal from the experience of attending the program and presenting her work.
 
“I really enjoyed this conference, particularly the Nutrition and Cancer Research Interest group, because it allowed me to be surrounded by people in my field,” she said. “Discussing my research with others also interested in or working on isothiocyanates gave me some promising future directions to pursue.”
 
Aaron Dom, a first-year MUSOM student and graduate of the Biomedical Sciences Graduate ProgramIn addition, Aaron M. Dom, a first-year medical school student from Wellersburg, Pa., was invited to do a special oral “blitz” presentation about his research on how a synthetic drug called MG624 can prevent new blood vessel growth in small cell lung cancer and could potentially serve as a therapy for the disease. Dom was invited to present by the Blood Vessel Club of the American Society for Investigative Pathology (ASIP). ASIP held its annual meeting in conjunction with the Experimental Biology conference. The club sponsors the short oral presentations to present exciting new vascular biology research and to give audience members an opportunity to provide feedback and suggestions about the research.
 
Dom, who is the president of the medical school’s Class of 2015, did the research in the lab of Dr. Piyali Dasgupta, assistant professor in the Department of Pharmacol­ogy, Physiology and Toxicology.
 
He said of the experience, “Our lab is honored that I was selected to present at this special session, and we were excited to share some of the work that we are doing here at the medical school. Experiences like these—in both helping with this research and in presenting at and attending a conference of this size—have helped me gain a greater appreciation for research in medicine.”
 
Nearly 14,000 scientists and exhibitors representing academic institutions, government agencies, non-profit organizations and private corporations attend the annual Experimental Biology meeting to share information about recent developments in anatomy, physiology, biochemistry, pathology, nutrition and pharmacology.

Biomedical Sciences students recognized at international science meeting

M. Allison Wolf, Ph.D. candidateHUNTINGTON, W.Va. – Two Marshall University students received special recognition for their research at this year’s international Experimental Biology conference held April 21-25 in San Diego.

M. Allison Wolf, a biomedical sciences doctoral candidate from Parkersburg, received first place in her group in a poster competition held as part of the conference’s Diet and Cancer mini-symposium. The mini-symposium was funded by the American Society of Nutrition.

Wolf’s presentation focused on her research on the anticancer effects of isothiocyanates—a natural compound extracted from cruciferous vegetables—on head and neck cancer. Her work shows the compound both inhibits head and neck metastasis and greatly increases sensitivity to chemotherapy in therapy-resistant head and neck cancers. Wolf works in the lab of Dr. Pier Paolo Claudio, an associate professor in the Biomedical Sciences Graduate Program and the departments of Biochemistry and Microbiology and Surgery at the university’s Joan C. Edwards School of Medicine.

Wolfe said she gained a great deal from the experience of attending the program and presenting her work.

“I really enjoyed this conference, particularly the Nutrition and Cancer Research Interest group, because it allowed me to be surrounded by people in my field,” she said. “Discussing my research with others also interested in or working on isothiocyanates gave me some promising future directions to pursue.”

Aaron Dom, a first-year MUSOM student and graduate of the Biomedical Sciences Graduate ProgramIn addition, Aaron M. Dom, a first-year medical school student from Wellersburg, Pa., was invited to do a special oral “blitz” presentation about his research on how a synthetic drug called MG624 can prevent new blood vessel growth in small cell lung cancer and could potentially serve as a therapy for the disease. Dom was invited to present by the Blood Vessel Club of the American Society for Investigative Pathology (ASIP). ASIP held its annual meeting in conjunction with the Experimental Biology conference. The club sponsors the short oral presentations to present exciting new vascular biology research and to give audience members an opportunity to provide feedback and suggestions about the research.

Dom, who is the president of the medical school’s Class of 2015, did the research in the lab of Dr. Piyali Dasgupta, assistant professor in the Department of Pharmacol­ogy, Physiology and Toxicology.

He said of the experience, “Our lab is honored that I was selected to present at this special session, and we were excited to share some of the work that we are doing here at the medical school. Experiences like these—in both helping with this research and in presenting at and attending a conference of this size—have helped me gain a greater appreciation for research in medicine.”

Nearly 14,000 scientists and exhibitors representing academic institutions, government agencies, non-profit organizations and private corporations attend the annual Experimental Biology meeting to share information about recent developments in anatomy, physiology, biochemistry, pathology, nutrition and pharmacology.

BMS researchers present at international scientific meetings

HUNTINGTON, W.Va. – Marshall University biomedical sciences researchers are presenting their work in the fields of toxicology and cancer biology at international scientific meetings this month and in April.

Monica Valentovic, Ph.D.Dr. Monica Valentovic, a professor in the Department of Pharmacology, Physiology and Toxicology, presented at last week’s Society of Toxicology Annual Meeting in San Francisco. Her talk focused on her lab’s work to evaluate ways to reduce the side effects of cancer chemotherapeutic drugs.

Mike Brown, a biomedical sciences doctoral candidate working in Valentovic’s lab, also presented at the conference. He discussed his research examining ways to reduce liver damage caused by acetaminophen use.

In addition, Valentovic served as chairman of the meeting’s Renal Toxicology Session.

The conference is the largest toxicology meeting and exhibition in the world, with attendance of more than 7,500 scientists from academia, government and industry from around the globe.

Another biomedical sciences doctoral candidate, Johannes Fahrmann, will be presenting his research to explore the effects of omega-3 fatty acids in early stage chronic lymphocytic leukemia at next month’s Experimental Biology conference in San Diego.

W. Elaine Hardman, Ph.D.

Fahrmann works in the lab of Dr. W. Elaine Hardman, a professor in the Department of Biochemistry and Microbiology. Valentovic will also be presenting at Experimental Biology. In that talk, she will discuss her work to examine the mechanisms for reducing cancer chemotherapy adverse effects to the kidney. That research was funded by the National Institutes of Health.

Also presenting at Experimental Biology 2012 will be M. Allison Wolf, a biomedical sciences doctoral candidate in the lab of Pier Paolo Claudio, M.D., Ph.D. She is disseminating her research on the anticancer effects of isothiocyanates, a natural compound extracted from cruciferous vegetables, on head and neck cancer. Her work shows that isothiocyanates both inhibit head and neck metastasis and greatly increase the sensitivity to chemotherapy in therapy-resistant head and neck cancers.

Nearly 14,000 scientists and exhibitors representing academic institutions, government agencies, non-profit organizations and private corporations attend the annual Experimental Biology meeting to share information about recent developments in anatomy, physiology, biochemistry, pathology, nutrition and pharmacology.

For more information, contact Valentovic at 304-696-7332 or valentov@marshall.edu, or Hardman at 304-696-7339 or hardmanw@marshall.edu.

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