Funding for collaborative medical research announced at Marshall University

Translational research aims to transfer discoveries from the laboratory to the bedside quickly

Wednesday, Feb. 27, 2013

HUNTINGTON, W.Va. – Marshall University Joan C. Edwards School of Medicine officials today announced $150,000 in funding for six research grants associated with the school’s translational medicine research program.

The Marshall Health Translational Pilot Grant program, created in 2012, encourages collaborative research between basic scientists and clinical physicians in an effort to speed up the process of laboratory discovery to clinical application for patients.  The grants are funded by Marshall Health.

“We are very pleased that Marshall Health has created this grant program to stimulate research efforts,” said Richard M. Niles, Ph.D., senior associate dean for Biomedical Sciences at the School of Medicine. “Moving Marshall to the next level of medical research takes vision, commitment and of course, funding.  This grant allows 12 researchers, as well as medical residents and students, the opportunity to explore very diverse areas.”

Marshall Health is the faculty practice plan for the Joan C. Edwards School of Medicine and supports the clinical, educational, research and services missions of the school.  Beth Hammers, executive director of the organization, says the pilot grant program provides one year of support at $25,000 for each grantee, with additional funding based on progress of the research.

“Medical research is essential to the development of new medical treatments and cures for patients,” Hammers said.  “We are thrilled to help stimulate a robust, viable grant program which pairs basic scientists from Marshall University with School of Medicine physicians to work on projects which will lead to the betterment of our community.”

The investigators and their projects are listed below:

Dr. Pier Paolo Claudio, Department of Biochemistry and Microbiology, and Dr. Anthony Alberico, Department of Neuroscience – “Chemotherapy resistance and sensitivity testing in tumors of the central nervous system”

Dr. Elaine Hardman, Department of Biochemistry and Microbiology, and Dr. James Jensen, Department of Surgery – “Feasibility and Safety of Nutritional Supplementation with Omega-3 Fatty Acids to Reduce Prostate Specific Antigen Rise in Men with Biochemical Failure after Prostatectomy or External-Beam Radiotherapy”

Dr. Nalini Santanam, Department of Pharmacology, Physiology and Toxicology, and Dr. Paulette Wehner, Department of Cardiology – “Perivascular Fat Relation to Hypertension—Appalachian Heart Study”

Dr. Nalini Santanam, Department of Pharmacology, Physiology and Toxicology, and Dr. Abid Yaqub, Department of Medicine, Endocrinology Section – “Impact of Technology-based Behavioral Intervention on Molecular and Clinical Parameters in Patients with Type 2 Diabetes”

Dr. Monica Valentovic, Department of Pharmacology, Physiology and Toxicology, and Dr. Brenda Dawley, Department of Obstetrics and Gynecology – “Prenatal Exposure to Heavy Metals and Polycyclic Aromatic Hydrocarbons (PAH) Alter Umbilical Cord Blood Levels of Thyroid Hormone and Vitamin D”

Dr. Hongwei Yu, Department of Biochemistry and Microbiology, and Dr. Yoram Elitser, Department of Pediatrics – “Investigate the distribution of segmented filamentous bacteria (SFB) in American children and the presence of SFB with childhood diseases”

Other current translational research under way at the Marshall University Joan C. Edwards School of Medicine includes a partnership with the University of Kentucky (UK) as part of the National Institutes of Health’s Clinical and Translational Science Awards program, which also is aimed at speeding the time for laboratory discoveries to benefit patients.

In 2011, UK and its partners received $20 million for the program to support research at UK’s Center for Clinical and Translational Science, making Marshall part of a select national biomedical research network.


Contact:  Ginny Painter, Communications Director, Marshall University Research Corporation, 304.746.1964, or Leah C. Payne, Director of Public Affairs, Schools of Medicine and Pharmacy, 304-691-1713

Ray awarded the ASBMB Graduate Travel Award

by: Allison Wolf, MU Biomedical Sciences Ph.D. candidate

BMS Ph.D. student Kristeena Ray was awarded The American Society for Biochemistry and Molecular Biology (ASBMB) Graduate Minority Travel Award, which is funded through a grant to the Federation of American Societies. Kristeena will travel to Boston, Massachusetts in April to present her research on the possible role of epigenetics in endometriosis at the 2013 Experimental Biology Conference. 

Kristeena Ray_web

Dr. Nalini Santanam, Kristeena’s mentor, stated, “Not much is known about the etiology of endometriosis. There are recent indications that epigenetics might be playing a role in its etiology. Kristeena’s project will, in the long-term, identify epigenetic markers that can be used as therapeutic targets for the treatment of endometriosis and/or its associated symptoms such as pain.”

Ray is the second BMS student to be notified of receiving a travel award to attend this international research conference. Dr. Santanam is pleased that Kristeena is one of the students selected for the ASBMB travel award and said that this opportunity will allow Kristeena to “meet peers from around the country, as well as listen and interact with expert scientists in basic and biomedical sciences.” 

Congratulations, Kristeena!

Marshall biomedical professor invited to present her research internationally

Nalini Santanam, Ph.D., M.P.H., professor in the Department of Pharmacology, Physiology and Toxicology in the Joan C. Edwards School of Medicine at Marshall University, has been invited to present her research, yet again.

2nd World Congress on Fertility and Antioxidants Therapy 2012Dr. Santanam will be presenting her research internationally at the International Society of Antioxidants in Nutrition and Health’s (ISANH) 2nd World Congress on Fertility and Antioxidants Therapy, December 6 – 7, 2012 in Paris, France.

Santanam’s talk is relevant to all with a condition called Endometriosis. Endometriosis is a clinical condition that afflicts 10-15% of women of reproductive age (mainly diagnosed between the ages of 25 and 35), posing a major cause for infertility and chronic pain. Since the etiology of this disease is still unknown, very few treatment options are available. Surgery is currently the best treatment; however, due to a high recurrence rate, the disease commonly returns within three to six months post-surgery. The conference provides attendees the opportunity to present and discuss new research relating to the condition. Dr. Santanam’s talk scheduled for Friday, December 7th, is titled “Prostaglandin-Like Lipid Oxidation Products in the peritoneal Fluid of Women with Endometriosis Respond to Antioxidant Therapy.” In addition to her presentation, she also will be co-sharing the meeting on December 7th, 2012. Dr. Santanam would like to acknowledge the continued collaboration with Dr. Brenda Dawley from the Department of Obstetrics and Gynecology. 

It is quite an honor to be selected at such a high level in her field, and though Dr. Santanam is not foreign to these invites, she remains humble. This is the second time she has been recognized and invited to present her research in just two months. Dr. Santanam recently presented her research at the American Heart Association’s Scientific Sessions in Los Angeles, California in November. Her talk was titled  “Sex differences in epicardial fat biomarkers,” which highlighted the research she has conducted over the past three years in collaboration with Marshall’s Department of Cardiology and Department of Cardiovascular and Thoracic Surgery. She studied the adipose tissue surrounding the heart and blood vessels in patients with coronary artery disease. 

This epicardial and perivascular fat has unique biomarkers that show differences between Nalini Santanam, Ph.D., M.P.H. the sexes; she states that with this study, they are “trying to identify biomarkers unique to this particular fat so that we can use it in the future to diagnose or in the treatment of coronary artery disease.”  Additionally, the biomarkers found in the adipose tissue have been correlated to patients with hypertension. This study is part of the West Virginia Appalachian Heart Study; therefore most of the individuals included in this study are Appalachians. Dr. Santanam would like to acknowledge: Dr. Christopher Adams, Dr. Nepal Chowdhury, Dr. Todd Gress, and Dr. Paulette Wehner.

Dr. Santanam is the chair of the Cardiovascular Disease, Obesity, and Diabetes research cluster within Marshall’s Joan C. Edwards School of Medicine Biomedical Sciences Graduate Program, and is a member of its Department of Pharmacology, Physiology and Toxicology. 

Congratulations on your continued achievements, Dr. Santanam!

Marshall biomedical sciences’ researchers publish e-book on nutrition and cancer

Cover of "Nutrition and Cancer: From Epidemiology to Biology"Researchers at Marshall University’s Joan C. Edwards School of Medicine have collaborated on an electronic book, “Nutrition and Cancer From Epidemiology to Biology,” recently published by Bentham Science Publishers.

This ebook is one of the latest efforts of researchers at the Marshall University Nutrition and Cancer Center.

A collection of scientific articles written by Marshall faculty members and students, the publication was edited by Dr. Richard M. Niles, professor and chairman of the university’s Department of Biochemistry and Microbiology, and Dr. Pier Paolo Claudio, associate professor in the Department of Biochemistry and Microbiology and director of the McKown Translational Genomic Research Institute.

According to the publisher, various estimates suggest that between 30-40% of all human cancers are related to dietary patterns. Strong epidemiological evidence from studies points to dietary constituents that either contribute or protect against the development of various forms of cancer.

This e-book reviews some traditional and relatively new areas of nutrition and cancer. Epidemiological data is combined with molecular biology research and, where available, clinical trial data. The emerging science of “Nutrigenomics” is discussed with chapters on the biological role of various nutrition components from red wine, peppers, green tea, fish oil, cruciferous vegetables, retinoids; and the intersection of nutrition and epigenetics in hematopoiesis.

The publication will be of interest to researchers in the nutrition and cancer fields, physicians in family and community medicine, internal medicine and oncology, and dieticians providing counseling to cancer patients and cancer survivors.

by Ginny Painter
Director of Communications
Marshall University Research Corporation
ginny.painter@marshall.edu
www.marshall.edu/murc

 

Marshall WV-INBRE summer research program intern receives ABRCMS travel award

Mardochee Isme, MU WV-INBRE InternMardochee Isme, a senior student at Bluefield State College in Bluefield, West Virginia, and a 2012 participant in West Virginia IDeA Network of Biomedical Research Excellence’s (WV-INBRE) Summer Research Program at Marshall University, is the winner of a Student Travel Award from the Annual Biomedical Research Conference for Minority Students (ABRCMS). Isme will attend the 2012 ABRCMS conference located in San Jose, CA, November 7 – 10, 2012 to present her research. The travel award is worth $1,500 and can go toward any travel-related expenses to the conference and/or conference registration fees.

Isme, among other students, performed research at Marshall University with Dr. Nalini Santanam, a professor in the Department of Pharmacology, Physiology and Toxicology at Marshall University’s School of Medicine and Coordinator of the Cardiovascular Disease, Obesity, and Diabetes Research Cluster. The abstract for her research is titled, “Epigenetics of endometriosis-associated pain.” Dr. Santanam’s laboratory is interested in the etiology of endometriosis and Mardochee’s research looked at the epigenetics of the disease, which as Dr. Santanam stated, “is a new area of research.”  

Kristeena Ray, a Marshall University Biomedical Sciences Ph.D. candidate in Dr. Santanam’s laboratory, helped Mardochee with her research and will continue this work as the focus of her own Ph.D. research. Dr. Santanam’s laboratory also has submitted a request for an NIH grant for further research in this field. Dr. Santanam would like to thank Dr. Brenda Dawley from the Department of Obstetrics and Gynecology at Joan C. Edwards School of Medicine for providing samples for this research project.

JCE School of Medicine Faculty Present Research at the National IDeA Meeting

Every two years the National IDeA Symposium of Biomedical Research Excellence (NISBRE) meeting is held in Washington D.C. to bring together faculty, fellows and students that participate in the National Institutes of Health’s Institutional Development Award (IDeA) programs. This year the NISBRE meeting was held June 25-27, 2012 at the Benja Lamyaithong Marshall INBRE studentOmni Shoreham Hotel and was attended by six faculty members from the Joan C. Edwards School of Medicine, Marshall University in the West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) program, three from West Virginia University and one each from Bluefield State College, Concord College, West Virginia State University, West Virginia Wesleyan College and the University of Charleston. Several of the Marshall University faculty presented research during the meeting including Drs. Monica Valentovic, Nalini Santanam Nalini Santanam, Ph.D./M.P.H.and Travis Salisbury from the Department of Pharmacology, Physiology and Toxicology and Dr. Donald Primerano from the Department of Biochemistry and Microbiology. Also presenting research was Andre Benja Lamyaithong, an undergraduate student at Wheeling Jesuit University, who has been conducting research on antidotes for acetaminophen overdose with Dr. Valentovic for two summers as part of the West Virginia INBRE summer research program. Other JCE School of Medicine faculty members attending the meeting were: Dr. Jim Denvir, Department of Biochemistry and Microbiology, who co-authored the work with Dr. Primerano; and Dr. Gary Rankin, Department of Pharmacology, Physiology and Toxicology, who is a member of the Executive Planning Committee for the NISBRE meeting.

 

Monica Valentovic, Ph.D.Dr.Valentovic’s research on how a component of grapes and red wine (resveratrol) can reduce damage to the kidney caused by a commonly used drug (cisplatin) to treat cancer was presented in a regular research session and highlighted in a special session on clinical and translational research. In addition, Dr. Primerano’s research into the genetics of families with high blood cholesterol was highlighted in a special session on cardiovascular disease.

The IDeA program was started in 1993 to help increase the biomedical research competitiveness in states that receive only small amounts of research funding from the National Institutes of Health. The IDeA program is composed of two award programs, one (Centers Of Biomedical Research Excellence; COBRE) that is designed to create centers with a biomedical research focus at larger research schools and a second program (INBRE) designed to build the biomedical research infrastructure at smaller colleges and universities and provide biomedical research training primarily to undergraduate students. Currently, 23 states and Puerto Rico Travis Salisbury, Ph.D.are eligible to compete for COBRE or INBRE grants. Marshall University was awarded an INBRE grant as the lead institution in 2004 with West Virginia University serving as a partner lead institution.  Dr. Gary Rankin, Professor and Chair of the Department of Pharmacology, Physiology and Toxicology at Marshall University is the Principal Investigator for the WV-INBRE program.

Drs. Claudio and Niles co-edit and publish an ebook on nutrition and cancer featuring BMS professors and students

Cover of "Nutrition and Cancer: From Epidemiology to Biology"Pier Paolo Claudio, M.D./Ph.D., and Richard M. Niles, Ph.D., of the Biomedical Sciences Graduate Program have co-edited and written articles in an ebook entitled “Nutrition and Cancer: From Epidemiology to Biology.” This ebook is one of the latest efforts of cancer researchers at the Marshall University Nutrition and Cancer Center, where the role of nutrition in cancer is actively and successfully investigated. The ebook contains a collection of scientific articles, written by researchers and students in the Marshall University Biomedical Sciences Graduate Program.  

The purpose of this publication is to educate and inform the public regarding the latest knowledge on nutrition and cancer. It focuses on the role of various nutritional components in cancer prevention, as well their present and future use in cancer therapy. According to Dr. Pier Paolo Claudio, “This e-book will be of interest to researchers in the nutrition and cancer field, physicians in family and community medicine, internal medicine and oncology, as well as dieticians providing counseling to cancer patients and cancer survivors.”

Dr. Niles says that the best description of the importance of this book can be found within the foreword, written by Dr. Gary Meadows of Washington State University:

“While we as individuals cannot modify our genetic makeup and may have little control over the multitude of carcinogens in our environment, we have the power to make healthy diet-based choices that can significantly modify cancer risk and progression. The authors have structured this book not only to review the epidemiological studies that support the roles of selected nutrients/phytochemicals in cancer control, but also they review the cellular and molecular pathways involved in their action as well as the clinical data related to their efficacy in cancer treatment. Consequently, this book has wide appeal not only to researchers in the nutrition and cancer field, but also to oncology practitioners, dieticians, as well as cancer survivors, who are interested learning how healthy dietary choices can enhance their quality of life.” 

According to Dr. Niles, editing the book involved reviewing each chapter and making suggestions for improvement of the content handwriting. He also co-wrote a chapter with Dr. Rankin on resveratrol, found in high concentration in red wine, and its ability to inhibit the development or progression of certain types of cancer. Dr. Claudio co-wrote an article with Ph.D. candidate M. Allison Wolf on isothiocyanates, phytochemicals found in cruciferous vegetables, which his lab found to target carcinogenesis during tumor initiation, promotion, and progression.

The following authors and articles are found within the ebook:

Richard M. Niles, Ph.D. and Gary O. Rankin, Ph.D.
Resveratrol, A Phytoalexin with a Multitude of Anti-Cancer Activities

Jamie K. Lau, Kathleen C. Brown, Aaron M. Dom and Piyali Dasgupta, Ph.D.
Capsaicin: Potential Applications in Cancer Therapy

W. Elaine Hardman, Ph.D.
Omega-3 Fatty Acids as an Adjuvant to Cancer Therapy

Richard Egleton, Ph.D.
Green Tea Catechins and Cancer

Kinsley Kelley Kiningham, Ph.D., and Anne Silvis
Receptor Independent Effects of Retinoids

Vincent E. Sollars, Ph.D.
Epigenetics as a Mechanism for Dietary Fatty Acids to Affect Hematopoietic Stem/Progenitor Cells And Leukemia – Royal Jelly for the Blood

Monica Valentovic, Ph.D. and Nalini Santanam, Ph.D./M.P.H.
Nutrition, Oxidative Stress and Cancer

John Wilkinson IV, Ph.D.
Is there an Etiologic Role for Dietary Iron and Red Meat in Breast Cancer Development?

M. Allison Wolf and Pier Paolo Claudio, M.D./Ph.D.
Isothiocyanates Target Carcinogenesis During Tumor Initiation, Promotion and Progression

The ebook can be ordered directly online through the Bentham Science website at the following link: http://198.247.95.142/ebooks/9781608054473/index.htm