Professor and Research Cluster Coordinator
Department: Biochemistry and Microbiology; Pediatrics
Research Cluster: Infectious and Immunological Diseases
Office: BBSC 336-S | Laboratories: BBSC 315 and 331
Phone: (304) 696-7356 | Fax: (304) 696-7207
The following story from the Marshall University Research Corporation (MURC) features Progenesis Technologies, co-founded by Biomedical Sciences Graduate Program professors Dr. Hongwei Yu and Dr. Richard Niles. Progenesis is a research and development company focused on demonstrating the feasibility of manufacturing its genetically-engineered bacterial alginates on an industrial scale. It is one of the “high-tech spinout companies” from Marshall University mentioned in the article.
The largest annual global event for the biotechnology industry, the BIO International Convention attracts an audience of more than 15,000 biotech business leaders, scientists, executives and investors from around the world.
Dr. John Maher, Marshall’s vice president for research, says the Bioscience Association of West Virginia (BioWV)—along with the West Virginia Development Office and the Biotech Alliance of the Huntington Area Development Council (HADCO)—is hosting a West Virginia Pavilion at the convention.
Maher, who is also vice-chairman of BioWV, said the Marshall-related companies to be featured at the pavilion include Vandalia Research, Progenesis Technologies and Cordgenics. All three businesses were founded based on technologies developed at Marshall and are headquartered in the state.
“The West Virginia Pavilion will highlight key participants in our state’s life sciences community,” he said. “There is a great deal of very exciting biotechnology work happening here at Marshall and we are pleased to have this opportunity to share it with conference attendees from the rest of the country and around the world.”
Bryan Brown, executive director of BioWV, added, “Not only will the West Virginia Pavilion highlight the outstanding bioscience companies in West Virginia and the excellent biomedical research at our major universities, we will also showcase all the state has to offer in terms of quality of life and increased business competitiveness to our colleagues from the rest of the country and around the world. We hope that participation in this event will help to attract new entrepreneurs, inventors, researchers, investors and businesses to West Virginia.”
BIO International Convention attendees include a mix of biotechnology, pharmaceutical, plant and life science, medical diagnostic, instrumentation and technology companies of all sizes, including the top 10 pharmaceutical companies in the world. Also represented are economic development organizations and businesses that support the industry, including law firms, service providers, investors, and suppliers of laboratory equipment and products. Representatives from more than 200 universities and academic communities also attend for networking, educational sessions and collaboration opportunities. There is a strong international attendance, with participants from approximately 60 countries.
Marshall University is a founding member of the Bioscience Association of West Virginia. The purpose of the association is to promote and strengthen the bioscience industry in the state by developing a cohesive community that unites biotechnology, pharmaceutical, medical device and research organizations. To advance this mission, BioWV provides educational, networking and commercial opportunities for its members, and serves as an educational and information resource to advance public understanding about the bioscience industry. For more information, visit www.biowv.org.
HUNTINGTON Hongwei Yu, chief science officer and co-founder of Progenesis Technologies, is in the market for new business cards after the company hosted a grand opening in its new Huntington office and lab in the Red Cross Building.
As West Virginia’s only locally owned and operated genetic engineering company, Progenesis recently changed its address from South Charleston to Huntington, a move that was celebrated during a grand opening at the new office Friday.
The company has long had ties to Huntington, as it is a spin-off of sorts from Marshall University, where Yu is a professor.
The company, which was founded in 2008, had been operating out of South Charleston until moving into the Red Cross Building and beginning renovations in January.
Most of the Progenesis work force lives in Huntington, so Friday’s grand opening had been eagerly anticipated, Yu said.
“We are very excited to get to work so close to home,” Yu said. “It will make a big difference between shuttling back and forth. We work with the Biotechnology Center at Marshall, so this will allow us to come in anytime we want to or need to and be able to do our work more efficiently.”
Progenesis is a research and development company, which is focused on demonstrating the feasibility of manufacturing its genetically-engineered bacterial alginates on an industrial scale.
Bacterial alginates absorb water quickly, which makes them useful in everything from the agricultural and food industries to the cosmetic and drug markets.
In addition to the new office space, Progenesis’ new digs include a bigger, brighter lab space for employees to do their work in, said Richard Niles, CEO of Progenesis.
“It really is going to be a wonderful place to work,” Niles said. “We are on an upward curve of developing our product and the company, and these new facilities are part of the attraction of significant revenue that will allow us to add more employees, which is what we need to continue to produce and test the product of this company.”
While the company is the only one of its kind in the state, Niles said he sees a bright future for biotechnology in Huntington.
“We are part of a new group of companies, which, locally, includes Vandalia, in biotechnology, which is a growing field. It’s one that is going to diversify the economy in Huntington,” Niles said. “Anyone who is curious about what we do is welcome to come and look at what it is we’re doing. All it takes is giving us a call setting up a time to visit.”
The following article was taken from the website of the Huntington Herald-Dispatch. It highlights the work of many of the professors researching in the Biomedical Sciences Graduate Program at Marshall University.
CHARLESTON - There is no shortage of exciting research going on in the laboratories at Marshall University. Scientists and technicians from this region and from around the world have converged at Marshall to do research on topics such as heart disease, cancer and many others. Their research might one day save a life, or at least make someone’s life better.Their work might not be easy for the layperson to understand, but university and business officials are working diligently to help ensure the work West Virginia’s scientists are doing also results in three simple words: dollars and cents.
The economic potential for bioscience research in West Virginia is still hard to grasp, but there is a lot happening already and much optimism for the future.
“We are looking at a pipeline of commercial opportunities coming out of research being done in West Virginia,” said John Maher, vice president for research at Marshall University.
Officials from Marshall, West Virginia University and several business related to the bioscience industry gathered last week for the Second Annual West Virginia Bioscience Summit, held Wednesday at the Marriott Hotel in Charleston.
“This conference is a unique opportunity for people interested in the biosciences to get together and get an update on the status of the industry over the last year,” said Derek Gregg, CEO of Vandalia Research here in Huntington and chairman of BioWV.
The summit featured presentations from West Virginia University, Marshall, Mountwest Community & Technical College, Vandalia Research, Protea, TRAX Biodiscovery, and others to talk about what their organizations have accomplished over the past year.
“This also allows new collaborations and partnerships to be developed,” Gregg said. “Additionally, we had substantial representation from out-of-state organizations looking for new partners and opportunities.”
The biosciences in West Virginia are growing rapidly and the state’s credibility is increasing in the United States and around the world, Gregg said.
“We are spinning out new enterprises, and some of those enterprises are raising capital and hiring people,” he said. “Protea was recently recognized world-wide as having one of the top 10 innovations of 2011. They now employee over 50 people.”
Four companies are now being housed and supported at Vandalia Research’s facility in Huntington, including Progenesis, Maven Analytical and Parabon Nanolabs. These companies sell to pharmaceutical, chemical and diagnostic companies around the world, Gregg said.
Marshall has a lot of exciting research under way right now, said Dr. Richard Niles, senior associate dean for Research and Graduate Education at Marshall’s Joan C. Edwards School of Medicine.
Here are some examples:
Dr. Piyali Dasgupta is looking at lung cancer and at how capsaicin, the hot stuff in chili peppers, which inhibits the growth of cancer cells in animals.
Dr. Nalini Santanam is looking at the effects of age and gender on the fat around the heart, and at oxidative stress in endometriosis.
Dr. Eric Blough of the Center for Diagnostic Nanosystems has 16 different projects going on.
Dr. Jingwei Xie is working with glass tubes for bone tissue engineering.
Dr. Hongwei Yu is working on genetic regulation of biofilm formation by pseudomonas aeruginosa, a bacterium that can cause disease in animals.
Dr. Pier Paolo Claudio is doing cancer research that involves gene therapy using microbubbles for delivery of a virus.
Niles is co-founder with Yu on the biotech business Progenesis, which provides natural, biodegradable polymers for industrial and medical applications through genetic engineering of bacteria. He talked about his experience of starting a biotech business at Wednesday’s Summit.
The universities are working to help others make discoveries and translate them into businesses as well. And the state is helping.
Both Marshall and WVU have received state funding for research through the West Virginia Research Trust Fund, providing $35 million to WVU and $15 million to Marshall for research, provided they come up with a match. WVU has reached its goal and Marshall has $9.4 million secured in gifts and pledges and the potential to reach, or go beyond, its goal very shortly, Maher said.
The universities also have attracted a lot of federal grant funding, all of which rolls over in the local economies as it provides high-paying jobs that attract scientists to the community.
Also in Huntington, Mountwest Community and Technical College is hard at work training students to become biological technicians, environmental science and environmental protection technicians, biomedical laboratory technicians and health technicians, said Jean Chappel, dean of Allied Health at MCTC.
It has a state-of-the-art lab where they can learn molecular diagnostics, tissue culturing, electrophoresis and use a digital fluorescent microscope.
MCTC also works on community outreach, not only targeting science teachers but high school and middle school students. It has a camp where “they’re isolating DNA just like they do on CSI,” Chappel said.
Over the course of one week, students’ aspirations might change from working a minimum wage job to becoming a PhD scientist, she said.
The college wants to help the state have “a well-rounded, educated workforce that wants to stay right here,” Chappel said.
It’s great to see several different parties working toward the same goal, said Laura Gibson, deputy director of the Mary Babb Randolph Cancer Center and a professor at WVU.
“The greatest measure of our success is really how we partner,” she said.
Capital formation, attraction and retention of talent, and community development are focus areas for Bio West Virginia in the coming years, Gregg said.
“Incentivizing investment in this area is critical,” he said, “Nearly all of our neighboring states have a program or programs for stimulating investment in high-technology, high-growth, high-RISK businesses to stimulate economic development. West Virginia has had programs in the past that were successful in helping companies raise capital, such as the High Growth Business Investment Tax Credit.
“BioWV is strongly encouraging the renewal of this and other programs that can help companies transition from the campus to the market.”