Biomedical Sciences graduate students present at the Annual Research Day

Anne Silves, Biomedical Sciences Ph.D. candidateThe Joan C. Edwards School of Medicine recently held its 23rd Annual Research Day. This event highlights the basic and clinic research work of basic scientists, medical students, graduate students, physicians, residents, and other interested health professionals. The goal of the Annual Research Day is to involve the community in the ongoing research being performed at the School of Medicine by allowing participants to formally present their research in oral or poster presentations.

Aileen Marcelo, Biomedical Sciences Ph.D. CandidateGraduate Students in the Biomedical Sciences Program at Marshall University had a strong showing at the event. Juliana Akinsete (Ph.D. Candidate), Aaron Dom (M.S. Medical Sciences Student), Meagan Valentine (Ph.D. Student), Anne Silvis (Ph.D. Candidate), and Gabriela Ion, Ph.D. (Post-doctoral Fellow) gave oral presentations. Ben Owen (M.S. Research Student), Siva Nalabotu (Ph.D. Candidate), and Aileen Marcelo (Ph.D. Candidate) presented posters.

One oral presenter and one poster presenter awarded in each of the three categories: clinical vignettes, clinical science, and basic science. In the basic science category, Anne Silvis and Aileen Marcello were the award winners.

BMS Ph.D. candidate publishes in International Journal of Nanomedicine

FOR IMMEDIATE RELEASE

Thursday, Nov. 17, 2011

Contact: Ginny Painter, Communications Director, Marshall University Research Corporation, 304-746-1964

ginny.painter@marshall.edu

Marshall University study shows nanoparticles being used as additives

in diesel fuels can travel from lungs to liver, causing damage

Eric Blough, Ph.D.HUNTINGTON, W.Va. – Recent studies conducted at Marshall University have demonstrated that nanoparticles of cerium oxide – common diesel fuel additives used to increase the fuel efficiency of automobile engines – can travel from the lungs to the liver and that this process is associated with liver damage.

The data in the study by Dr. Eric R. Blough and his colleagues at Marshall’s Center for Diagnostic Nanosystems indicate there is a dose-dependent increase in the concentration of cerium in the liver of animals that had been exposed to the nanoparticles, which are only about 1/40,000 times as large as the width of a human hair. These increases in cerium were associated with elevations of liver enzymes in the blood and histological evidence consistent with liver damage. The research was published in the Oct. 13 issue of the peer-reviewed research journal International Journal of Nanomedicine.

Cerium oxide is widely used as a polishing agent for glass mirrors, television tubes and ophthalmic lenses. Cerium oxide nanoparticles are used in the automobile industry to increase fuel efficiency and reduce particulate emissions. Some studies have found that cerium oxide nanoparticles may also be capable of acting as antioxidants, leading researchers to suggest these particles may also be useful for the treatment of cardiovascular disease, neurodegenerative disease and radiation-induced tissue damage.

Blough, the center’s director and an associate professor in the university’s Department of Biological Sciences, said, “Given the ever-increasing use of nanomaterials in industry and in the products we buy, it is becoming increasingly important to understand if these substances may be harmful. To our knowledge, this is the first report to evaluate if inhaled cerium oxide nanoparticles exhibit toxic effects in the liver.”

Dr. Siva K. Nalabotu, the study’s lead author and a Ph.D. student in Blough’s lab, said, “The potential effects of nanomaterials on the environment and cellular function is not yet well understood. Interest in nanotoxicity is rapidly growing.

“Our studies show that cerium oxide nanoparticles are capable of entering the liver from the lungs through the circulation, where they show dose-dependent toxic effects on the liver. Our next step is to determine the mechanism of the toxicity.”

The research was supported with funding from the U.S. Department of Energy, grant DE-PS02-09ER09-01.

For more information, contact Blough at blough@marshall.edu or 304-696-2708.