Funding for collaborative medical research announced at Marshall University

Translational research aims to transfer discoveries from the laboratory to the bedside quickly

Wednesday, Feb. 27, 2013

HUNTINGTON, W.Va. – Marshall University Joan C. Edwards School of Medicine officials today announced $150,000 in funding for six research grants associated with the school’s translational medicine research program.

The Marshall Health Translational Pilot Grant program, created in 2012, encourages collaborative research between basic scientists and clinical physicians in an effort to speed up the process of laboratory discovery to clinical application for patients.  The grants are funded by Marshall Health.

“We are very pleased that Marshall Health has created this grant program to stimulate research efforts,” said Richard M. Niles, Ph.D., senior associate dean for Biomedical Sciences at the School of Medicine. “Moving Marshall to the next level of medical research takes vision, commitment and of course, funding.  This grant allows 12 researchers, as well as medical residents and students, the opportunity to explore very diverse areas.”

Marshall Health is the faculty practice plan for the Joan C. Edwards School of Medicine and supports the clinical, educational, research and services missions of the school.  Beth Hammers, executive director of the organization, says the pilot grant program provides one year of support at $25,000 for each grantee, with additional funding based on progress of the research.

“Medical research is essential to the development of new medical treatments and cures for patients,” Hammers said.  “We are thrilled to help stimulate a robust, viable grant program which pairs basic scientists from Marshall University with School of Medicine physicians to work on projects which will lead to the betterment of our community.”

The investigators and their projects are listed below:

Dr. Pier Paolo Claudio, Department of Biochemistry and Microbiology, and Dr. Anthony Alberico, Department of Neuroscience – “Chemotherapy resistance and sensitivity testing in tumors of the central nervous system”

Dr. Elaine Hardman, Department of Biochemistry and Microbiology, and Dr. James Jensen, Department of Surgery – “Feasibility and Safety of Nutritional Supplementation with Omega-3 Fatty Acids to Reduce Prostate Specific Antigen Rise in Men with Biochemical Failure after Prostatectomy or External-Beam Radiotherapy”

Dr. Nalini Santanam, Department of Pharmacology, Physiology and Toxicology, and Dr. Paulette Wehner, Department of Cardiology – “Perivascular Fat Relation to Hypertension—Appalachian Heart Study”

Dr. Nalini Santanam, Department of Pharmacology, Physiology and Toxicology, and Dr. Abid Yaqub, Department of Medicine, Endocrinology Section – “Impact of Technology-based Behavioral Intervention on Molecular and Clinical Parameters in Patients with Type 2 Diabetes”

Dr. Monica Valentovic, Department of Pharmacology, Physiology and Toxicology, and Dr. Brenda Dawley, Department of Obstetrics and Gynecology – “Prenatal Exposure to Heavy Metals and Polycyclic Aromatic Hydrocarbons (PAH) Alter Umbilical Cord Blood Levels of Thyroid Hormone and Vitamin D”

Dr. Hongwei Yu, Department of Biochemistry and Microbiology, and Dr. Yoram Elitser, Department of Pediatrics – “Investigate the distribution of segmented filamentous bacteria (SFB) in American children and the presence of SFB with childhood diseases”

Other current translational research under way at the Marshall University Joan C. Edwards School of Medicine includes a partnership with the University of Kentucky (UK) as part of the National Institutes of Health’s Clinical and Translational Science Awards program, which also is aimed at speeding the time for laboratory discoveries to benefit patients.

In 2011, UK and its partners received $20 million for the program to support research at UK’s Center for Clinical and Translational Science, making Marshall part of a select national biomedical research network.


Contact:  Ginny Painter, Communications Director, Marshall University Research Corporation, 304.746.1964, or Leah C. Payne, Director of Public Affairs, Schools of Medicine and Pharmacy, 304-691-1713

Marshall biomedical sciences’ researchers publish e-book on nutrition and cancer

Cover of "Nutrition and Cancer: From Epidemiology to Biology"Researchers at Marshall University’s Joan C. Edwards School of Medicine have collaborated on an electronic book, “Nutrition and Cancer From Epidemiology to Biology,” recently published by Bentham Science Publishers.

This ebook is one of the latest efforts of researchers at the Marshall University Nutrition and Cancer Center.

A collection of scientific articles written by Marshall faculty members and students, the publication was edited by Dr. Richard M. Niles, professor and chairman of the university’s Department of Biochemistry and Microbiology, and Dr. Pier Paolo Claudio, associate professor in the Department of Biochemistry and Microbiology and director of the McKown Translational Genomic Research Institute.

According to the publisher, various estimates suggest that between 30-40% of all human cancers are related to dietary patterns. Strong epidemiological evidence from studies points to dietary constituents that either contribute or protect against the development of various forms of cancer.

This e-book reviews some traditional and relatively new areas of nutrition and cancer. Epidemiological data is combined with molecular biology research and, where available, clinical trial data. The emerging science of “Nutrigenomics” is discussed with chapters on the biological role of various nutrition components from red wine, peppers, green tea, fish oil, cruciferous vegetables, retinoids; and the intersection of nutrition and epigenetics in hematopoiesis.

The publication will be of interest to researchers in the nutrition and cancer fields, physicians in family and community medicine, internal medicine and oncology, and dieticians providing counseling to cancer patients and cancer survivors.

by Ginny Painter
Director of Communications
Marshall University Research Corporation
ginny.painter@marshall.edu
www.marshall.edu/murc

 

Drs. Claudio and Niles co-edit and publish an ebook on nutrition and cancer featuring BMS professors and students

Cover of "Nutrition and Cancer: From Epidemiology to Biology"Pier Paolo Claudio, M.D./Ph.D., and Richard M. Niles, Ph.D., of the Biomedical Sciences Graduate Program have co-edited and written articles in an ebook entitled “Nutrition and Cancer: From Epidemiology to Biology.” This ebook is one of the latest efforts of cancer researchers at the Marshall University Nutrition and Cancer Center, where the role of nutrition in cancer is actively and successfully investigated. The ebook contains a collection of scientific articles, written by researchers and students in the Marshall University Biomedical Sciences Graduate Program.  

The purpose of this publication is to educate and inform the public regarding the latest knowledge on nutrition and cancer. It focuses on the role of various nutritional components in cancer prevention, as well their present and future use in cancer therapy. According to Dr. Pier Paolo Claudio, “This e-book will be of interest to researchers in the nutrition and cancer field, physicians in family and community medicine, internal medicine and oncology, as well as dieticians providing counseling to cancer patients and cancer survivors.”

Dr. Niles says that the best description of the importance of this book can be found within the foreword, written by Dr. Gary Meadows of Washington State University:

“While we as individuals cannot modify our genetic makeup and may have little control over the multitude of carcinogens in our environment, we have the power to make healthy diet-based choices that can significantly modify cancer risk and progression. The authors have structured this book not only to review the epidemiological studies that support the roles of selected nutrients/phytochemicals in cancer control, but also they review the cellular and molecular pathways involved in their action as well as the clinical data related to their efficacy in cancer treatment. Consequently, this book has wide appeal not only to researchers in the nutrition and cancer field, but also to oncology practitioners, dieticians, as well as cancer survivors, who are interested learning how healthy dietary choices can enhance their quality of life.” 

According to Dr. Niles, editing the book involved reviewing each chapter and making suggestions for improvement of the content handwriting. He also co-wrote a chapter with Dr. Rankin on resveratrol, found in high concentration in red wine, and its ability to inhibit the development or progression of certain types of cancer. Dr. Claudio co-wrote an article with Ph.D. candidate M. Allison Wolf on isothiocyanates, phytochemicals found in cruciferous vegetables, which his lab found to target carcinogenesis during tumor initiation, promotion, and progression.

The following authors and articles are found within the ebook:

Richard M. Niles, Ph.D. and Gary O. Rankin, Ph.D.
Resveratrol, A Phytoalexin with a Multitude of Anti-Cancer Activities

Jamie K. Lau, Kathleen C. Brown, Aaron M. Dom and Piyali Dasgupta, Ph.D.
Capsaicin: Potential Applications in Cancer Therapy

W. Elaine Hardman, Ph.D.
Omega-3 Fatty Acids as an Adjuvant to Cancer Therapy

Richard Egleton, Ph.D.
Green Tea Catechins and Cancer

Kinsley Kelley Kiningham, Ph.D., and Anne Silvis
Receptor Independent Effects of Retinoids

Vincent E. Sollars, Ph.D.
Epigenetics as a Mechanism for Dietary Fatty Acids to Affect Hematopoietic Stem/Progenitor Cells And Leukemia – Royal Jelly for the Blood

Monica Valentovic, Ph.D. and Nalini Santanam, Ph.D./M.P.H.
Nutrition, Oxidative Stress and Cancer

John Wilkinson IV, Ph.D.
Is there an Etiologic Role for Dietary Iron and Red Meat in Breast Cancer Development?

M. Allison Wolf and Pier Paolo Claudio, M.D./Ph.D.
Isothiocyanates Target Carcinogenesis During Tumor Initiation, Promotion and Progression

The ebook can be ordered directly online through the Bentham Science website at the following link: http://198.247.95.142/ebooks/9781608054473/index.htm

24th Annual Research Day hosted at Marshall University School of Medicine

M. Allison Wolf, Ph.D. candidateOn March 20th, the Marshall University School of Medicine hosted its 24th Annual Medical School Research Day. This medical-school wide event, which also encompasses the Biomedical Sciences Graduate Program, is one of the few times in the academic year that everyone in the school community gathers to learn about the research taking place at the Joan C. Edwards School of Medicine (JCESOM).

The event included nearly 80 research presentations and a keynote speech by Dr. William Thies, the Chief Medical and Science Officer for the National Alzheimer’s Organization. The goals of Research Day include giving participants an opportunity to formally present their research, involving the community in the ongoing research being performed at JCESOM, and encouraging Continuing Medical Education in clinical research.

The presenters included professors, graduate students, postdoctoral fellows, medical students, and residents. On the ground floor of the Marshall Medical Center, dozens of research projects were presented. According to Dr. Richard Niles, Senior Associate Dean of Research and Graduate Education, the research presented ranged from Vitamin D3 supplementation to chili peppers and small cell lung cancer.

The following members of the Biomedical Sciences Graduate Program participated:

  • Dr. Piyali Dasgupta
  • Dr. Jung Han Kim
  • Flavia De Carlo, a postdoctoral fellow in Dr. Pier Paolo Claudio’s lab
  • Johannes Francois Fahrmann, a Ph.D. candidate in Dr. Elaine Hardman’s lab
  • Rounak Nande, a Ph.D. student in Dr. Pier Paolo Claudio’s lab
  • Aaron Dom, a medical student and former Medical Sciences Master’s student researching in Dr. Piyali Dasgupta’s lab
  • M. Allison Wolf, a Ph.D. candidate in Dr. Pier Paolo Claudio’s lab
  • Meagan Valentine, a Ph.D. student in Dr. Simon Collier’s lab
  • Miranda Carper, a Ph.D. candidate in Dr. Pier Paolo Claudio’s lab
  • Sarah Mathis, a Ph.D. student in Dr. Pier Paolo Claudio’s lab

The event followed an Alzheimer’s Disease Symposium, which took place on March 19th. Dr. Richard Egleton of the BMS Graduate Program was a guest speaker.

A few members of the BMS Graduate Program also received honors for their presentations at Research Day. M. Allison Wolf’s poster, entitled “Benzyl isothiocyanate targets chemoresistant and metastatic head and neck cell carcinoma cells,” won in the Poster Basic Science category. A researcher in Dr. Piyali Dasgupta’s lab, Clayton Crabtree, won in the Oral Basic Science category for his presentation, “Capsaicin induces apoptosis in human small cell lung cancer via the TRPV pathway.”

To learn more about the 24th Annual Research Day, look to the event website: http://musom.marshall.edu/research/. You can also download the following pdf documents directly:

Research Day 2012 Syllabus

Research Day 2012 Winners

Drs. Hardman and Georgel highlighted by DoD Breast Cancer Research Program

Dr. Philippe Georgel and Dr. W. Elaine HardmanDr. Philippe Georgel and Dr. W. Elaine Hardman have received considerable publicity in the past few years over their receipt of a grant from the Department of Defense’s Breast Cancer Research Program. Their most recent honor comes in being highlighted in the latest program book for the Congressionally Directed Medical Research Programs’ (CDMRP) Breast Cancer Research Program. Their research, the result of a DoD FY09 Idea Expansion award, is entitled “Maternal Consumption of Omega-3 Fatty Acids May Prevent Breast Cancer in Offspring.”

In 1992, the CDMRP was created after breast cancer advocates were able to bring about congressional appropriation of funds dedicated to breast cancer research. The fund seeks to find a way to stamp out breast cancer through support of research that is innovative and has the potential of great impact in the understanding of breast cancer. The CDMRP has received more than $6.5 billion in appropriations since its creation. Receipt of the award comes after a two-tier review process consisting of participation between breast cancer survivors and research scientists. Award of the grant is based upon the relevance of the research to the goals of the program and the scientific merit of the proposed research.

The research of Drs. Hardman and Georgel is directed toward determining which gene expression changes in mice offspring are brought about by feeding pregnant mice a diet that includes canola oil (which contains omega-3) versus a diet that contains corn oil (a control). They then compare the mammary cancer rates of the offspring groups after they are exposed to a carcinogen. Results from their research already indicate differences in microRNA and epigenetic expression in the offspring, as well as changes in the expression of genes related to mammary tumorigenesis, including NF-kappaB.

Congratulations to Dr. Georgel and Dr. Hardman! To read the spotlight on their research in the CDMRP booklet (see page 19), please download the file through this link: http://cdmrp.army.mil/pubs/pips/bcpip.pdf.

Dr. W. Elaine Hardman publishes in Nutrition and Cancer

W. Elaine Hardman, Ph.D.Dr. W. Elaine Hardman has published an article in the most recent issue of Nutrition and Cancer, entitled “Dietary Walnut Suppressed Mammary Gland Tumorigenesis in the C(3)1 TAg Mouse.” In her study, including walnuts in the diets of mice lowered their incidence of developing cancer by 50%. The mice that did develop cancer presented with 50% less tumors. This is in comparison to control mice whose diet did not include walnut.

What makes the results of the study even more astounding is that Dr. Hardman was working with mice that were genetically predisposed to developing breast cancer. Genetic analysis showed that eating a walnut-containing diet altered the expression of many genes involved in the development of breast cancer, not only in mice, but also in humans. The compounds in walnuts that have been shown to slow cancer progression include antioxidants, omega-3 fatty acids, and phytosterols.

Read the entire article online on the Nutrition and Cancer website. A video story featuring Dr. Hardman is also available on the Marshall University YouTube channel

Dr. W. Elaine Harman featured in the Parthenon

The Marshall University student newspaper, the Parthenon, has run a feature article on Dr. W. Elaine Hardman in its March 10, 2011 issue. The article highlights Dr. Hardman’s education, research, and life story. The full text of the piece can be found below and on the Parthenon Website.


W. Elaine Hardman, Ph.D.Elaine Hardman was at Cabell Huntington Hospital one day picking up blood samples to test while carrying a bag of toothbrushes and tubes of toothpaste.

“What are you doing with that?” asked Theodore Witte, Hardman’s research assistant and part-time doctoral student in the biomedical sciences program at Marshall University.

Witte said she saved them from all the hotels she has stayed at and gives them to the women’s shelter.

“How many people do you see doing that?” Witte said. “She doesn’t even consider herself decent; she just is.”

Hardman is the associate professor for the department of biochemistry and microbiology at Marshall and has been at Marshall for five years.

“We were very fortunate to recruit her to Marshall,” said Richard Niles, senior associate dean for research and graduate programs.

Niles met Hardman when they first worked together a couple years ago in the same study section for the American Institutes for Cancer Research. After working with Hardman, he encouraged her to apply for the open position available at Marshall.

“I knew what I was getting myself into before I applied for the job,” Hardman said.

Philippe Georgel, associate professor for biological sciences, said he met Hardman at her interview. He said she was very professional, but his first impression was that she was very quiet.

“I realized there is a lot of energy under that calm surface,” Georgel said. “She is extremely energetic and I think she is one of those researchers who thinks if there is something that can help and benefit others, she will do her best to include other people in her research and in her success.”

Hardman has been researching the subjects of nutrition and cancer for the past 20 years.

Hardman served six years as a member of the National Institutes of Health study section and spent five years on the Susan G. Komen Breast Cancer Foundation study section.

Some of her earlier research was on the effects of dietary fiber on colon cancer. Now she is studying the effects of omega-3 fatty acids on various cancers, including lung, prostate, breast and colon.

Hardman said her passion for science began in junior high school. She grew up in a small town in the backwoods area of Dicey County, Fla., and always found some interest in science.

She said she asked her mom and dad for a chemistry set, but instead she received a microscope.

However, there was a dilemma.

“At the time I was growing up, what did a girl who liked science do?” Hardman said. “Maybe I could be a nurse or a science teacher, but I finally realized I wanted to be a researcher and I didn’t have a clue how to get there.”

Hardman said the only thing she thought of was to take all the science she could in high school.

By her junior year, she had taken all the science and math courses her high school provided. She decided to go to junior college and ended up graduating a year early from high school.

Within 15 months at junior college in Florida, Hardman completed her two years and went to the University of Florida. Then, seven months later, she finished her junior year at the university and was 18 years old.

She then married and had a family.

“I always knew I was still going to finish college,” Hardman said.

Hardman said she believes her marriage came at the right time.

“It worked for me,” Hardman said. “It enabled me to focus on raising my children when I was young and had more energy. It has also given me enough time at a later time in my life to get back into science and focus on it.”

The family moved to Montgomery, Ala., at the time her youngest of two children, Don, entered preschool. Hardman said then was the perfect time to go back to school and finish her degree.

Auburn University had just started a clinical laboratory, medical technology course, and Hardman said she was interested in it. She went to the department chair and asked what she should do in the field of science. He suggested she enroll in the new technology course.

She said she realized that, even though it was a delightful experience, she could not stand the idea of doing the same type of work every day for the rest of her career.

Her family moved again to San Antonio, Texas, where Hardman found a part-time job at the Cancer Research Therapy Center as a medical technologist.

“I was working with cancer patients,” Hardman said. “I was reading their blood smears, learning about their cancers and learning about their treatment.”

At the time her oldest child, Sharon, entered college, Hardman said she heard about a full-time position as a research assistant available at the University of Texas Science Center.

Hardman said she was ready for a full-time job and started working hard at it. Two years into the position, she said she practically ran the project the center was working on.

Again, however, Hardman made the decision to go back to school and further her education. This time she applied for graduate school at the University of Texas and finished her doctoral degree in cell biology in two years and three months.

“Most students work at it for five to six years,” Hardman said. “But I had already been working on it in the lab for two years.”

As a graduate student, she received her first grant funded by the American Institute for Cancer Research and a pre-doctoral grant. She has also received funding from the Department of Defense and the National Institutes of Health for her research throughout the years.

“Things have fallen into place for me,” Hardman said. “Partly because I was ready for the next step and the next step would come at the time I was ready for it.”

Out of the lab, Hardman can be found cross-country skiing, around campus or in the park, according to some of her students.

“Whenever there is enough snow, she will go do that,” said Anne Silvis, a biomedical sciences doctoral candidate for cancer biology from Hurricane, W.Va. “She is very adventurous and she is going to do whatever she wants to do and she really doesn’t care what people are going to think. She really enjoys life.”

Hardman said she was once a Girl Scout and likes to help with teaching young girls how to white water raft. She also said she likes to stay active, and her students seem to be a little jealous of that.

“Well despite her age, she is perhaps the most active person I know and would probably put me to shame in terms of physical health, and I consider myself in pretty good shape,” said Johannes Fahrmann, a biomedical sciences doctoral student from Dresden, Germany.

Hardman even plans surprise trips for her students. Witte said Hardman would take her lab members on a boat ride for lab meetings.

“Unbelievably, you think that you’re going into a scary lab meeting and you find that you’re going on a boat ride and she is making upside-down cake,” Witte said. “The trick is that she grandmothers us into performing, so you can’t let her down.”

Many of the students interviewed said she was a wonderful role model to them. Silvis said she is inspired by Hardman’s success in the field of science as a woman who has a family.

“She is very important to me having a family myself,” Silvis said. “It’s very comforting. And I think for women to see that, even though she has a family and kids in graduate school, they can accomplish as much as she has in her professional life and still have a family life.”

Hardman said she hopes she is always directing her students in the right direction but may not think she is necessarily the right leader for the job.

“I have always thought of myself as fairly shy, but other people say that I’m a pretty strong leader,” Hardman said. “I don’t quite see that.”

“Things have fallen into place for me; partly because I was ready for the next step and the next step would come at the time I was ready for it.”

-Elaine Hardman