Translational Geriatric Research

Acetaminophen intervention as a rejuvenate medicine Aging-related hyperglycemia is associated with increased oxidative stress and diminished muscle glucose transporter that may be regulated, at least in part, by the mitogen-activated protein kinases (MAPK). Aged skeletal muscle is characterized by an increased incidence of metabolic and functional disorders, which if allowed to proceed unchecked can lead to increased morbidity and mortality. Cardiovascular disease (CVD) is responsible for more than 30% of all deaths worldwide and heart failure is the leading cause of death in individuals more than 65 years of age. The mechanism(s) underlying the development of these age-associated disorders are not well understood. Acetaminophen is easily tolerated and exhibits potent anti-oxidant activity. We investigate how acetaminophen intervention, if present, can attenuate age-associated increases in hyperglycemia and disorders in skeletal muscle and heart.