TEXT: Biological Monitoring, An Introduction; Shane S.Que Hee, Editor; Van Nostrand Reinhold, 115 Fifth Ave NY NY, 10003

COURSE DESCRIPTION: The course covers the rationale for a Biological Monitoring program. Toxicokinetics, hazard potentials, and mechanism for exposure measurements also are discussed.

COMPUTER REQUIREMENTS: Familiarity with the use of the Internet.

INSTRUCTOR: Dr. John A. Singley,

212C Communications Building.

Office hours posted in the department, see the Department Secretary.

Telephone 696-3067

CREDITS: Three

PREREQUISITES: At least one prior Industrial Hygiene course, either SED 454 or SED 647 or

equivalent. Good working knowledge of Chemistry (211/212 ,217/218. Knowledge of Biology is also essential.

LEARNING OUTCOME: The course is designed to give the student the latest information in

Biological Monitoring so that the student can establish a biological monitoring program when they are employed.

* the toxicokinetics of several substances in humans.

* the use of newer and better biological markers of exposure measurements.

* assessment of the relationship between the biological marker of exposure and the risk of adverse effects.

* guidelines for the evaluation of potential health hazards in industry.

* understanding which biological markers that are of practical use for assessing exposure to industrial chemicals.

EVALUATION AND MEASUREMENT OF STUDENT PROGRESS: The student will be responsible for both lecture and textbook material. In addition, a term paper about some aspect of Biological Monitoring will be required of each student. Further, the student will be required to give a 15 minute oral presentation about their paper. The presentation should not be a reading of the paper. Presentations will start during the seventh class period. Four students will be alloted 15 minutes, requiring one hour of each class for the presentations. Who presents on what week will be determined by lots, the first class period. It is expected that the student will adhere strictly to the presentation schedule. The topic of the paper is left to the student, but do not choose an overly broad topic. The paper needs to be at least ten pages in length and should have at least 12 references. The paper should follow the format similar to paper published in leading safety and industrial hygiene journals. Such journals are available in the department library and the main library. .

POLICY STATEMENT The use of tobacco in any form is prohibited in the classroom. In addition, Students shall not wear any hats in class, unless they have a medical or religious need. There will be no excused absences except as discussed below. For a medical excuse a note from the physician must be turned in to the instructor. Absences for business reasons or for an immediate family emergency may be considered if contact is made with the instructor on a timely basis. Business reasons require a letter from your employer on letterhead stationary. The same rules apply for term paper presentation. Any quiz that is missed must be made up. Since a new quiz must be prepared, you will need to make arrangements with the instructor about the make up quiz. However the bottom line for absences is, an absence is an absence regardless of the reason.

Students also need to pay attention to each other's oral presentation,.since the final examination will include questions based on the presentations.

ATTENDANCE POLICY: Attendance at each class is expected and attendance will be taken. Excessive absences will result in a lower grade. Tardiness also will be noted and could result in a lower grade..

GRADING: Quizzes 60% (15% each )

Term Paper 35%

Attendance, class participation 5%.

and unannounced quizzes

COURSE OUTLINE:

Wk 1 Concepts in Chemistry and Biochemistry Chapters 1 & 2

Wk 2 Exposure Routes, Disposition of Xenobiotics Chapters 3 & 4

Wk 3 Metabolism Chapters 5 & 6

Wk 4 Hour Quiz 1

Wk 5 Medical Sureillance and Markers Chapters 7, 8 & 9

Wk 6 Adducts Chapters 19, 11 & 12

Wk 7 Immunology Chapters 13 & 15

Wk 8 Hour Quiz 2

Wk 9 Protection Guidelines Chapter 18

Wk 10 Nitriles Chapter 19

Wk 11 Quantiative Monitoring Chapter 29

Wk 12 Biological Indices Chapter 21

Wk 13 Hour Quiz 3

Wk 14 Pesticides Chapter 22

Wk 15 Hazardous Wastes Chapter 23

Wk 16 Hour Quiz 4

BIBLIOGRAPHY:

Biological Monitoring Methods for Industrial Chemists; 1980; Randall C. Bassalt; Biomedical Publishers, Davis CA

Surface and Dermal Monitoring for Toxic Exposures; 1994; Shirley A. Ness; Van Nostrand Reinhold, 115 Fifth Ave, NY NY 10003

Industrial Chemical Exposure-Guidelines for Biological Monitoring; 1991; Robert R. Lauwey and

Perrine Hoet,; Lewis Publishers, 2000 Corporate Blvd, NW, Boca Raton Fl.