TEXT: Essentials of Environmental Toxicology; 1996; W. William Hughes; Taylor & Francis, 1101 Vermont Avenue, NW Suite 200 Washington DC 20005-3521.

COURSE DESCRIPTION: The course will emphasize the principles of toxicology, dose-response relationships, xenotoxins, the distribution of toxins and the storage of toxins.

COMPUTER REQUIREMENTS: The ability to access and obtain information from the Internet

INSTRUCTOR: Dr. John A. Singley

212 C, Communications Building

Office hours posted in the department

See department Secretary for an appointment.

CREDITS: Three

PREREQUISITES: SED 454 or 554 or 647 or equivalent, Chemistry 211/212 and 217/218, Math 130

LEARNING OUTCOME: Since this is an introductory course in toxicology, it will emphasize an understanding of toxicology and concentrate on general principles and examples of these principles. The student will learn about toxicology concepts, dose-response relationship, how toxicants are absorbed, the distribution and storage of toxicants, the toxicology of target organs, teratogenesis, mutagenesis and carcinogenesis, and risk assessment. The course will provide the student with the knowledge necessary to make rational decisions about the toxicology of various agents.

EVALUATION AND MEASUREMENTS OF STUDENT PROGRESS: The student will be responsible for both lecture and reading material. In addition, a term paper about some aspect of toxicology will be required of each student. Further, the student will be required to give a 15 minute oral presentation about their paper. The presentation should not be a reading of the paper, but a synopsis of the topic. Strictly reading the paper will result in a reduction in the grade for the paper and report. The papers are due the 15th week of class. The topic of the paper is left to the student. However, the topic should not be so broad as to cover a vast field in toxicology, e.g. toxicants. Rather, the topic should be narrower in scope, e.g. liver toxicants. The paper needs to be at least ten pages in length and should have at least 12 references. The paper and the presentation should convey to the instructor the student's knowledge of the subject. The paper

should follow the format that is similar to papers published in leading safety of industrial hygiene publications. Examples of such publications are available in the department library and in the main Marshall library.

GRADES: Quizzes 45% (15% each), Term paper and oral presentation 25%, Homework problems 25%, Attendance and Classroom participation 5%.

ATTENDANCE POLICY: Attendance at each class is expected and attendance will be taken. Excessive absences will result in a lower grade. Further, since students are preparing to enter a profession where they will become part of the management system and will be expected to be punctual for meetings and with their reports, we will start the training in our classes. Tardiness for class will be noted and could also result in a lower grade.

There will be no classes during the University holidays and breaks.

POLICY STATEMENT: The use of tobacco in any form is prohited in the classroom. In addition, students shall not wear any hats in class, unless they have a medical or religious need. There will be no excused absences except for those discussed below. For a medical excuse a note from the physician must be turned in to the instructor. Absences for business reasons or for an immediate family emergency may be considered if contact is made with the instructor on a timely basis. Business reasons require a letter from your employer on letterhead stationary. The same rules apply for term paper presentations. Any quiz that is missed must be made up. Since a new quiz must be prepared , you will need to make arrangements with the instructor about the make up quiz. However, the bottom line for absences is, an absence is absence regardless of the reason..

Students also need to pay attention to each other's oral presentation since the last hour quiz will include some questions from the presentation materials.

COURSE OUTLINE:

Wk 1 Introduction to Environmental Toxicology. Pp 1-18

Wk 2 Toxicology Concepts. Pp 19-28

Wk 3 Dose-Response Relationship. Pp 29-42

Wk 4 Hour Quiz 1

Wk 5 Absorption of Toxicants. Pp 43-58

Wk 6 Distribution and Storage of Toxicants. Pp 59-70

Wk 7 Biotransformation and Elimination of Toxicants. Pp 71-84

Wk 8 Target Organ Toxicity. Pp 85-104

Wk 9 Hour Quiz 2

Wk 10 Teratogenesis, Mutagenesis, and Carcinogenesis. Pp 105-124

Wk 11 Environmental Toxicants. Pp 125-142

Wk 12 Mechanisms of Toxicity.

Wk 13 Risk Assessment. Pp 143-148

Wk 14 Hour Quiz 3

BIBLIOGRAPHY:

Biological Effects of Low Level Exposures in Dose-Response Relationships; 1994; Edward J. Calabrese, Editor; Lewis Publishers, Boca Raton,FL

Casserett and Doull's Toxicology; 1980; John Dould, Curtis Klassen and Mary O. Amdur, Editors; MacMillian Publishing Co, Inc NY NY

Industrial Toxicology; 1988; Philly L. Williams and James L. Burson, Editors, Van Nostrand Reinhold, 115 Fifth Ave, NY NY 10003