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Nutrition and Cancer Grants and Publications

Recent Research accomplishments: New grants 2009-10:

Principal Investigator(s):Gary O. Rankin
Project Title: West Virginia IDeA Network of Biomedical Research Excellence (WV- INBRE) 3P20RR016477-09S
Dates: 09/25/2009 – 09/24/2011
Total Budget: $651,385
Role on project: collaborator, 1.2 calendar months
Status: Funded, in progress

Principal Investigator: W. Elaine Hardman
Title: Maternal consumption of omega 3 fatty acids to reduce breast cancer risk in offspring
Dates: (approximate) July 1, 2010 to June 30, 2012
Total Budget: $781,000
Agency: Dept of Defense, Breast Cancer Research Program
Status: Funded, Sept 1, 2010

Principal Investigator: Anne Silvis/ W. Elaine Hardman, mentor
Title: Pre-doctoral award for Anne Silvis
Dates: June 1, 2010 to May 31, 2011
Total Budget: $12,000 Agency: WV-NASA Status:
Funded, Sept 1, 2010

Older current grants
5R01CA114018-03 9/14/ 2007 to 8/31/2011
NCI : $266,000/year, $1,064,000 total,
Agency: National Cancer Institute Status: Funded, In progress
Omega-3 fat to reduce risk for breast cancer

MG07A001 7/1/07 to 6/30/11
Am. Institute for Cancer Research/Calif. Walnut Council $120,000
Walnut consumption for benefit against prostate and breast cancer

Publications in last year
Research papers:

Varney, ME, Hardman, WE and Sollars, VE. Omega 3 fatty acids reduce myeloid progenitor cell frequency in the bone marrow of mice and promote progenitor cell differentiation. Lipids in Health and Disease. 2009, 8:9.

Ion, G., Akinsete, J.A. and Hardman, W.E. Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice. BMC Cancer. 2010 Mar 6;10(1):81. [Epub ahead of print].

Witte, TR, Salazar, AJ, Ballester, OF and Hardman, WE. RBC and WBC fatty acid composition following consumption of an omega 3 supplement: Lessons for future clinical trials. Lipids Health Dis. 2010 Mar 22;9:31.

Brown, KC, Witte, TR, Hardman, WE, Luo, H, Chen, YC, Carpenter, AB, Lau, JK, Dasgupta, P. Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway.PLoS One. 2010 Apr 20;5(4):e10243

Varney, ME, Buchanan, JT, Dementieva,Y, Hardman, WE, and Vincent E. Sollars. A high omega-3 fatty acid diet has different effects on early and late stage myeloid progenitors Lipids (in press), 2010.

Hardman, WE, Ion, G, Akinsete, JA, Witte, TR. Dietary walnut suppressed mammary gland tumorigenesis in the C(3)1 TAg mouse. Submitted to Nutrition and Cancer, Aug. 2010

Book Chapters:
Hardman, WE. The influence of -3 PUFAs on chemo- or Radiation Therapy for Cancer. In: Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer. Calviello, G. and Serini, S. editors, Springer. January 2010

Other news:
Invited speaker to: Korea-European Union Omega 3 Symposium, Chungnam National University, Daejeon Korea, June 8, 2010

Invited Speaker to: Korean Association of Cancer Prevention, Omega 3 Symposium, Yonsei University, Seoul, Korea, June 10, 2010.

   

Donald A. Primerano, PhD
Department of Biochemistry and Microbiology
Joan C. Edwards School of Medicine
Marshall University

Publications from MU investigators that acknowledge the Genomics Core Facility

  1. Global Analysis of Gene Expression Changes During Retinoic Acid-Induced Growth Arrest and Differentiation of Melanoma: Comparison to Differentially Expressed Genes in Melanocytes vs. Melanoma. Mary Estler, Goran Boskovic, James Denvir, Sarah Miles, Donald A. Primerano, and Richard M. Niles. (BMC Genomics 9:478- (2008)
  2. Qiu, D., F. H. Damron, T. Mima, H. P. Schweizer, and H. D. Yu. A series of PBAD-based shuttle vectors for functional analysis of toxic and highly-regulated genes in Pseudomonas and Burkholderia spp. and other bacteria. Appl. Environ. Microbiol. Published ahead of print on 10 October 2008, doi:10.1128/AEM.01369-08.
  3. Jing Li, Natalia Belogortseva, David Porter and Maiyon Park, Chmp1A functions as a novel tumor suppressor gene in human embryonic kidney and ductal pancreatic tumor cells. Cell Cycle 18: 7- (2008)
  4. S.E. Kelly, Di Benedetto M., Valluri J.V., and Claudio P.P. Rapid Selection and Proliferation of Cancer Stem Cells in a NASA Developed Microgravity Bioreactor. The European Space Agency (ESA) Meeting.  Life in Space for Life on Earth 22 - 27 June 2008 Angers – France.
  5. Qiu, D., V. M. Eisinger, N. E. Head, G. B. Pier and H. D. Yu. 2008. ClpXP proteases positively regulate alginate over-expression and mucoid conversion in Pseudomonas aeruginosa. Microbiol. 154: 2119-30.
  6. Poschet, J. F., G. S. Timmins, W. Ornatowski, J. Fazio, E. Perkett, K. R. Wilson, H. D. Yu, H. R. de Jonge, and V. Deretic. 2007. Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 293(3):L712-9.
  7. Sikorsky JA, DA Primerano, TW Fenger, and J. Denvir. 2007. DNA Damage Reduces Taq DNA polymerase and PCR Amplification Efficiency. Biochem. Biophys. Res. Comm. 355: 431-437.
  8. Qiu, D., V. M. Eisinger, D. W. Rowen, and H. D. Yu. 2007. Regulated proteolysis controls mucoid conversion in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 104: 8107-8112.
  9. Wilson, K. R., J. M. Napper, J. Denvir, V. E. Sollars, and H. D. Yu. 2007. Defect in early lung defense against Pseudomonas aeruginosa in DBA/2 mice is associated with increased pulmonary inflammation and reduced bactericidal activity in naive macrophages. Microbiol. 153: 968-979. (cites WV-INBRE Prog.)

Genomics Core Publications (co-authors in bold)

  1. Chromatin Stability at Low Concentration Depends on Histone Octamer Saturation Levels. Thomas Hagerman, Quang Fu, James Denvir, Stuart Lindsay and Philippe Georgel. Biophysical Journal 96:1944-51 (2009).
  2. Li, J. Orr, B. White, K., Belogortseva N., Niles R., Boskovic G., Nguyen H., Dykes A., Park M. Chmp1A is a mediator of the anti-proliferative effects of All-trans Retinoic Acid in human pancreatic cancer cells. Molecular Cancer 8:7-20 (2009).
  3. Proteomic and genomic analysis of PITX2 interacting and regulating networks. Yue Huang, Kan Huang, Goran Boskovic, Yulia Dementieva, James Denvir, Donald A. Primerano, Guo-Zhang Zhu. FEBS Letters XXX
  4. Global Analysis of Gene Expression Changes During Retinoic Acid-Induced Growth Arrest and Differentiation of Melanoma: Comparison to Differentially Expressed Genes in Melanocytes vs. Melanoma. M. Estler, G. Boskovic, J. Denvir, S. Miles, D. A. Primerano, and R. M. Niles. BMC Genomics 9:478- (2008)

 

W. Elaine Hardman, Ph.D.
Associate Professor
Department of Biochemistry and Microbiology
Byrd Biotechnology Science Center
Marshall University School of Medicine

Peer reviewed research reports

  1. Cameron, IL, Sun, LZ, Hardman, WE and Williams, CD. Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis. Cancer Cell Int. 2005 Jul 26;5:23.
  2. Hardman, WE, Sun, L.Z., Short, N. and Cameron, IL. Dietary omega-3 fatty acids and ionizing irradiation on human breast cancer xenograft growth and angiogenesis. Cancer Cell Int. 2005 Apr 28;5(1):12.
  3. Cameron, IL, Short, N, Sun, LZ and Hardman, WE. Endothelial cell pseudopods and angiogenesis of breast cancer tumors Cancer Cell Int. 2005 May 26;5(1):17.
  4. Cameron, IL, Kent, JE, Philo, R, Barnes, CJ, and Hardman, WE. Numerical Distribution of Lymphatic Nodules in Human Sigmoid Colon, Rectosigmoidal Junction, Rectum and Anal Canal. Clinical Anatomy, 2006: 19(2), 164-170.
  5. Hardman, WE. Dietary canola oil suppressed growth of implanted MDA-MB 231 human breast tumors in nude mice. Nutr and Cancer, 2007, 57(2), 177-183.
  6. Hardman WE and Ion, G. Walnut consumption for growth suppression of human MDA-MB 231 xenografts. Nutr and Cancer. 2008, 60(5), 666-674.
  7. Varney, ME, Hardman, WE and Sollars, VE. Omega 3 fatty acids reduce myeloid progenitor cell frequency in the bone marrow of mice and promote progenitor cell differentiation. Lipids in Health and Disease. Lipids in Health and Disease. 2009, 8:9.
  8. Ion, G., Akinsete, J.A. and Hardman, W.E. Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice. Breast Cancer Research, submitted 7/2009.

Book chapters

  1. Hardman, WE. Omega 3 fatty acids as an adjuvant to cancer therapy. In: Focus on Dietary Fats Research. M. V. Landow, editor, Nova Science Publishers, New York 2006
  2. Hardman, WE. Omega-3 PUFAs in combination with chemotherapic agents. In: Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer. Calviello, G. editor, Springer. In press: June 2009

 

Piyali Dasgupta, PhD.
Assistant Professor
Department of Pharmacology,
Physiology & Toxicology
Joan C. Edwards School of Medicine
Marshall University
R.C. Byrd Biotech Science Center

Chapters In Scholarly Books

  1. Pillai S, Dasgupta P., Chellappan SP (2009) Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo. In: CHROMATIN PROTOCOLS Ed. SP Chellappan, Methods Mol. Biol., 523, 323-329. Humana Press Inc., NJ, USA
  2. Dasgupta, P. and Chellappan, S. (2007) Chromatin immunoprecipitation assays: Molecular Analysis of chromatin modification and gene regulation, In: CANCER GENOMICs AND PROTEOMICS Ed. Paul Fischer, Methods Mol. Biol., 383, 135-152. Humana Press Inc., NJ, USA.

Journal Articles

  1. Egleton, R. D., Brown, K.C. and Dasgupta, P. (2009) Angiogenic Activity of Nicotinic Acetylcholine Receptors: Implications in Tobacco-related Vascular Diseases. Pharmacology & Therapeutics 121, 2, 205-223.
  2. Dasgupta, P., Rizwani, W., Pillai, S., Kinkade,R., Rastogi,S., Banerjee, S., Kovacs, M., , Carless, M., , E., Kim, Haura, E., Coppola, D. and Chellappan, S. (2009) Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. International J. Cancer 124, 1, 36-45 .
  3. Egelton, R.D., Brown, K.C., Dasgupta, P. (2008) Nicotinic Acetylcholine Receptors: Multiple Roles in Proliferation and Inhibition of Apoptosis Trends Pharmacol Sci , 29, 151-158.
  4. Kinkade, R., Dasgupta, P., Carie, A., Pernazza, D., Carless, M., Pillai, S., Lawrence, N., Sebti, S.M., Chellappan, S. (2008) A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice. Cancer Res., 68, 3810-3818.
  5. Dasgupta, P., Rastogi, S., Joshi, B., Pillai, S., Ordonez, D., Morris, M., Haura, E. and Chellappan, S. (2006) Nicotine induces cell proliferation by ?-arrestin mediated activation of Src and Rb-Raf-1 pathway. J. Clin. Invest., 116, 2208-17.
  6. Dasgupta, P., Kinkade, R., Joshi, B., DeCook, C., Haura, E. and Chellappan, S. (2006) Nicotine inhibits apoptosis induced by chemotherapeutic drugs by upregulating XIAP and survivin. Proc. Natl. Acad. Sci., USA, 103, 6332-7.
  7. Rastogi, S., Joshi, B., Dasgupta, P*., Morris, M., Wright, K. and Chellappan, S. (2006) Prohibitin facilitates cellular senescence by recruiting specific co-repressors to inhibit E2F-target genes. Mol. Cell. Biol. 26, 4161-71.
    * equal second author
  8. Dasgupta, P., Padmanabhan, J. and Chellappan, S. (2006) Rb function in the apoptosis and senescence of non-neuronal and neuronal cells: Role in Oncogenesis. Curr. Mol. Medicine 6, 719-29.
  9. Kinkade,R., Dasgupta, P. and Chellappan, S. (2006) The ABCs of Targeting Raf: Novel approaches to Cancer Therapy. Current Cancer Therapy Reviews 2, 305-14.
  10. Dasgupta, P. and Chellappan, S. (2006). Nicotine-mediated cell proliferation and angiogenesis: New Twists to an Old Story. Cell Cycle 5, 2324-28.

 

Vincent E. Sollars, Ph.D.
Director of the Flow Cytometry Core Associate Professor
Joan C. Edwards School of Medicine
Marshall University

  1. A high omega-3 fatty acid diet has different effects on early and late stage myeloid progenitors (2010). MelindaE. Varney, James T. Buchanan, Yulia Dementieva, W. Elaine Hardman and Vincent E. Sollars. Lipids (accepted).
  2. 17-N-Allylamino-17-demethoxygeldanamycin induces a diverse response in human acute myelogenous cells(2010). Jennifer Napper and Vincent E. Sollars. Leukemia Research 34(11), 1493-1500.
  3. Silencing and Re-expression of Retinoic Acid Receptor Beta2 in Human Melanoma (2010). Jun Fan, Linda Eastham, Mindy Varney, Adam Hall, Nicolas L. Adkins, Vincent E. Sollars, Phillipe Georgel, Richard M. Niles. Pigment Cell Melanoma Research 23 (3), 419-429.
  4. Rapid selection and proliferation of CD133(+) cells from cancer cell lines: chemotherapeutic implications (2010).Sarah E. Kelly, Altomare Di Benedetto, Adelaide Greco, Candace M. Howard, Vincent E. Sollars, Donald A. Primerano, Jagan V. Valluri, Pier Paolo Claudio. PLoS One 5(4): e10035.
  5. Omega 3 fatty acids reduce myeloid progenitor cell frequency in the bone marrow of mice and promote progenitor cell differentiation (2009). Melinda E. Varney, W. Elaine Hardman, and Vincent E. Sollars. Lipids in Health and Disease 8(9).
  6. Defect in early lung defense against Pseudomonas aeruginosa in DBA/2 mice is associated with acute inflammatory lung injury and reduced bactericidal activity in naïve macrophages (2007). Kari R. Wilson, Jennifer M. Napper, James Denvir, Vincent E. Sollars, and Hongwei D. Yu. Microbiology 153(4), pp. 968-979.
  7. Analysis of Pre-leukemic Expansion of Myeloid Progenitors in Inbred Strains of Mice (2006). Vincent E. Sollars, Edward Pequignot, Jay L. Rothstein, and Arthur M. Buchberg. Mammalian Genome 17(8), 808-821.
  8. Diversity in secreted PLA2-IIA activity among inbred mouse strains that are resistant or susceptible to ApcMin/+ tumorigenesis (2005). Marina Markova, Revati A. Koratkar, Karen A. Silverman, Vincent E. Sollars, Melina MacPhee-Pellini, Rhonda Walters, Juan P. Palazzo, Arthur M. Buchberg, Linda D. Siracusa and Steven A. Farber. Oncogene 24, 6450-6458.
  9. The Epigenomic Viewpoint on Cellular Differentiation of Myeloid Progenitor Cells as it Pertains to Leukemogenesis (2005). Vincent E. Sollars. Current Genomics 6 (3), 137-144.
  10. Epigenetic modification as an enabling mechanism for leukemic transformation (2005). Vincent E. Sollars. Frontiers in Bioscience 10, 1635-1646.
  11. Multigenerational selection and detection of altered histone acetylation and methylation patterns: toward a quantitative epigenetics in Drosophila (2004). Mark D. Garfinkel, Vincent E. Sollars, Xiangyi Lu, and Douglas M. Ruden. Methods Mol Biol 287, 151-168.
  12. Waddington’s Widget: Hsp90 and the inheritance of acquired characters (2003). Douglas M. Ruden, Mark D. Garfinkel, Vincent E. Sollars and Xiangyi Lu. Seminars in Cell and Molecular Biology 14, 301-310.
  13. Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution (2003). Vincent Sollars, Xiangyi Lu, Li Xiao, Xiaoyan Wang, Mark D. Garfinkel, and Douglas M. Ruden. Nature Genetics 33, pp. 70-74.
  14. A novel transgenic line of mice exhibiting autosomal recessive male-specific lethality and non-alcoholic fatty liver disease (2002). Vincent E. Sollars, Benjamin J. McEntee, Julie B. Engiles, Jay L. Rothstein and Arthur M. Buchberg. Human Molecular Genetics 11(22), pp. 2777-2786.
  15. Membrane Fusion Proteins are Required for oskar mRNA Localization in the Drosophila Egg Chamber. Douglas M. Ruden, Vincent Sollars, Xiaoyan Wang, Daisuke Mori, and Marina Alterman (2000). Developmental Biology 218, pp. 314-325.
  16. A Drosophila Kinesin-like Protein, Klp38B, Functions during Meiosis, Mitosis and Segmentation. Douglas M. Ruden, Wei Cui, Vincent Sollars, and Marina Alterman (1997). Developmental Biology 191, pp. 284-296.

Richard M. Niles, Ph.D.
Professor and Chair
Department of Biochemistry and Microbiology
Senior Associate Dean for Research and Graduate Education
Joan C. Edwards School of Medicine
Marshall University

 

  1. Niles, R.M. Biomarker and Animal Models for Assessment of Retinoid Efficacy in
    Cancer Chemoprevention. Acta Pharmacologica Sinica 28: 1383-1391, 2007.
  2. Eastham, L.L., Mills, C.N., and Niles, R.M. PPAR alpha/gamma Expression and
    Activity in Mouse and Human Melanocytes and Melanoma Cells. Pharm. Res.
    25:1327-1333, 2008.
  3. Huang, Y., Minigh, J., Miles, S., and Niles, R.M. Retinoic acid Decreases ATF-2
    Phosphorylation and Sensitizes Melanoma Cells to Taxol- Mediated Growth
    Inhibition. J. Mol. Signalling 3:3, 2008
  4. Estler, M., Boskovic, G., Denvir, J., Miles, S., Primerano, D.A., and Niles, R.M.
    Global Analysis of Gene Expression Changes During Retinoic Acid-Induced
    Growth Arrest and Differentiation of Melanoma: Comparison to Differentially
    Expressed Genes in Melanocytes vs. Melanoma. BMC-Genomics, 9:478 ,2008.
    Epub
  5. Li, J., Orr, B., White, K., Belogortseva, N., Niles, R., Boskovic, G., Nguyen, H., Dykes, A., and Park, M. Chmp 1A is a Mediator of the Anti-proliferative Effects of all-trans Retinoic acid in Human Pancreatic Cancer Cells. Mol. Cancer 8:7, 2009, Epub
  6. Fan, J., Zhu, G.Z., and Niles, R.M. Expression and Function of CD9 in Melanoma Cells. Mol. Carcinogenesis, In Press.

John Wilkinson, Ph.D.
Assistant Professor, Anatomy and Pathology Department
Joan C. Edwards School of Medicine
Marshall University

  1. Jiao Y, Wilkinson J 4th, Di X, Wang W, Hatcher H, Kock ND, D'Agostino R Jr, Knovich MA, Torti FM, Torti SV. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood. 2009 Jan 8;113:462-9.
  2. Yan Jiao, John Wilkinson IV, E. Christine Pietsch, Joan L. Buss, Roy P. Planalp, Frank M. Torti, Suzy V. Torti. Iron chelation in the biological activity of curcumin. Free Rad. Biol. Med., 40:1152-60, 2006.
  3. **John Wilkinson IV, E. Christine Pietsch, Suzy V. Torti, and Frank M. Torti. Ferritin Regulation By Oxidants and Chemopreventive Xenobiotics. Adv. Enzyme Regul. 43:135-151, 2003. (Review).
  4. Greene, B.T., Thorburn, J., Thorburn, A., Planalp, R.P., Brechbiel, M.W., Jennings-Gee, J., Wilkinson J. IV, Torti, F.M. and Torti, S.V., Activation of Caspase Pathways during Iron Chelator-Mediated Apoptosis J Biol Chem 277(28):25568-25575, 2002.
  5. Ruggeri, B.A., Robinson, C., Angeles, T., Wilkinson, J. IV, and Clapper, M.L. The Chemopreventive Agent Oltipraz Possesses Potent Anti-Angiogenic Activity In Vitro, Ex Vivo, and In Vivo, and Inhibits Tumor Xenograft Growth. Clin. Cancer Res. 8: 267-274, 2002.
  6. Cerda, S., Wilkinson, J., Branch, S.K., and Broitman, S.A.Enhancement of Sterol Synthesis by the Monoterpene Perillyl Alcohol is Unaffected by Competitive HMGCoA Reductase Inhibition. Lipids 34:605-615, 1999.
  7. Cerda, S., Wilkinson, J., Thorgeirsdottir, S., and Broitman, S.A. Perillyl Alcohol Induced Cell Cycle Changes , Altered Actin Cytoskeleton, and Decreased Ras and p34cdc2 expression in Colonic Adenocarcinoma SW480 Cells J Nut. Biochem. 10:19-30, 1999.
  8. John Wilkinson, IV and Margie L. Clapper Detoxication Enzymes and Chemoprevention. Proc. Soc. Exp. Bio. Med. 216:192-200, 1997. (Review)
  9. Selwyn .A. Broitman, John Wilkinson IV, Sonia Cerda, Steven K. Branch. Effects of Monoterpenes and Mevinolin on Murine Colon Tumor CT-26 in vitro and its Hepatic “Metastases” in vivo. Adv. Exp. Biol. Med., 401:111-130, 1996.
  10. Cerda, S., Wilkinson, J. IV, and Broitman, S.A. Regulation of cholesterol synthesis in 4 colonic adenocarcinoma cell lines. Lipids, 30:1083-1092, 1995.
  11. Selwyn A. Broitman, Sonia Cerda, and John Wilkinson IV, Cholesterol Metabolism and Colon Cancer. Prog. Food Nut. Sci., 17:1-40, 1993. (Review)
  12. John Wilkinson IV, Pathways in Biochemistry: Lipoprotein Metabolism. J. Nutritional Biochem, May, 1990. (Technical Illustration)

Pier Paolo Claudio, M.D., Ph.D.
Associate Professor Department of
Biochemistry and Microbiology &
Department of Surgery, Joan C. Edwards
School of Medicine Marshall University
R.C. Byrd Biotech Science Center

  1. Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP. Rapid selection and proliferation of CD133+ cells from cancer cell lines: chemotherapeutic implications. PLoS One 2010; 5 (4): e10035.
  2. Pedersini R, Vattemi E, Claudio PP.  Adenoviral gene therapy in high-grade malignant glioma.  Drug News Perspect. 2010 Jul-Aug;23(6):368-79.
  3. Vogiatzi P, Claudio PP.  Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer.  Expert Rev Anticancer Ther. 2010 Jul;10(7):1027-30.
  4.  Mukerjee,R.  Claudio, P.P.,  Chang, R.J.,  Del Valle, L. and Sawaya, B.E. Transcriptional regulation of HIV-1 gene expression by p53 cell cycle (Cell Cycle, in press, 2010).

 

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