Home    Members    News    Research    Publications    Genomics    Links    Contact

Nutrition and Cancer Research


Philippe Georgel, Ph.D.
Associate Professor
Byrd Biotechnology Building
Marshall University

Chromatin Structure and Function

Click here to view the slide show >

My laboratory is working on the role of sulforaphane (SFN), an isothiocynate compound present in cruciferous vegetables, in epigenetic modifications in the context of prostate cancer. The role of DNA methylation, histone post-translational modifications (PTM), and chromatin folding are investigated. Our initial focus was on two genes affected by SFN treatment, the tumor suppressor p21 and the human telomerase reverse-transcriptase (hTERT). In collaboration with Dr. Gordon Hager (NIH) and Roderick Dashwood (Oregon State University), we are specifically looking at the genome-wide changes in distribution of histone PTMs and recruitment of histone de-acetylases (HDAC) in response to SFN treatment

Vincent E. Sollars, Ph.D.
Director of the Flow Cytometry Core
Associate Professor

Curative strategies for chronic myelogenous leukemia

Curative strategies for chronic myelogenous leukemia (CML) blast crisis are inadequate. The progression of this disease to blast crisis is caused by blockage of differentiation in myeloid progenitor cells. Our preliminary data in mice show that omega-3 fatty acids can reduce myeloid progenitor cell levels and induce differentiation of these cells in vivo. We propose that dietary intake of omega-3 fatty acids can be used as a preventive strategy for blast crisis progression in CML. We hypothesize that omega-3 fatty acids can increase differentiation of bone marrow progenitor cells through epigenetic mechanisms and that this effect may be applicable to slowing progression of CML to blast crisis. Click here to read more >

Omega 3 fatty acids reduce myeloid progenitor cell frequency in the bone marrow of mice and promote progenitor cell differentiation

Click here to view the slide show >

Sollars Slide ShowDietary Omega-3 Fatty Acids can affect Myeloid Cell Development.


Richard M. Niles, Ph.D.
Professor and Chair
Department of Biochemistry and Microbiology
Senior Associate Dean for Research and Graduate Education
Joan C. Edwards School of Medicine
Marshall University

Our laboratory is investigating the mechanism by which dietary constituents such as vitamin A, resveratrol (red wine), quercetin (apples), etc arrest growth of melanoma cells and prevent melanocytes from being converted to melanoma cells. Melanoma is rapidly increasing in incidence, especially in the under 40 year old population. In its early stage, it is curable by surgery, but once its spreads, it is notoriously resistant to treatment.

Click here to view the slide show >

Sollars Slide Show


Piyali Dasgupta, PhD.
Assistant Professor
Department of Pharmacology,
Physiology & Toxicology
Joan C. Edwards School of Medicine
Marshall University
R.C. Byrd Biotech Science Center

Anti-neoplastic Activity of Capsaicin in Human Small Cell Lung Cancer

Small cell lung cancer (SCLC) is characterized by rapid progression, early metastasis and a dismal survival rate. My laboratory investigates the anti-cancer activity of the nutritional agent capsaicin in human SCLCs.

Capsaicin is the major active ingredient of chilli peppers. It exhibits chemopreventive effects in animal models, suppressing carcinogenesis of the skin, colon, lung, tongue, and prostate. Although, many studies have addressed the chemopreventive potential of capsaicin, only few have addressed its potential as an anti-cancer nutritional agent. Click here to read more >


W. Elaine Hardman, Ph.D.
Associate Professor
Department of Biochemistry and Microbiology
Byrd Biotechnology Science Center
Marshall University School of Medicine


Scientists think that about 1/3 to ½ of all cancers could be PREVENTED by dietary changes.

Hardman Slideshow ThumbnailA  goal of my research is to assess the ability of various dietary changes to prevent cancer.
Click here to read more >

John Wilkinson, Ph.D.
Assistant Professor, Anatomy and Pathology Department
Joan C. Edwards School of Medicine
Marshall University

Research Statement

Transsulfuration and Liver Cancer.  In January, Dr. Sollars and I were awarded an R21 grant from the National Cancer Institute to examine the impact of ethanol and iron on epigenetic mechanisms of importance to liver cancer development, that may in turn be influenced by transsulfuration. Click here to read more >

Home    Members    News    Research   Publications   Genomics    Links    Contact