Photo of Dr. Zijian Xie

Zijian Xie, Ph.D.
Director

Dr. Zijian Xie was named director of the Marshall Institute for Interdisciplinary Research in November 2013.

His laboratory is internationally recognized for its groundbreaking work to understand the behavior of cellular pathways and their relationship to cancer, renal disease and cardiac failure.

Xie holds international patents and patent applications on seven medical inventions resulting from his research. He has served as principal investigator, project leader or co-investigator on National Institutes of Health-funded projects totaling more than $10 million, and has established active international collaborations with total funding of more than $1 million. He has been involved with the creation of two spin-off companies from his research.

He is the author or co-author of more than 100 articles published in scientific journals, has authored a number of book chapters and has been invited to give numerous presentations as part of national and international conferences, symposia, seminars and visiting professorships. He serves as a regular member of NIH study sections and has chaired and co-organized several international symposia.

Dr. Xie came to Marshall from the faculty of the University of Toledo’s College of Medicine, where he was a professor of physiology, pharmacology and medicine, and served as the co-director of the M.D./Ph.D. program.

He earned a bachelor’s degree from the Nanjing College of Pharmacy in Nanjing, China, in 1982, a master’s degree in toxicology at the Chinese Academy of Medical Sciences in Beijing in 1984 and a doctorate in pharmacology at the Medical College of Ohio (now University of Toledo) in 1990.

Training

  • B.S., Pharmacy, 1982, Nanjing College of Pharmacy, Nanjing, P.R. China
  • M.S., Toxicology, 1984, Chinese Academy of Medical Sciences, Beijing, P.R. China
  • Ph.D., Pharmacology, 1990, Medical University of Ohio, Toledo, OH

Appointments

  • Director, Marshall Institute for Interdisciplinary Research, Marshall University, 2013-present
  • Professor of Medicine, Department of Medicine, University of Toledo College of Medicine, Health Science Campus, 2005-2013
  • Professor of Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, 2005-2013
  • Associate Professor of Medicine, Medical University of Ohio, 2001-2005
  • Associate Professor of Pharmacology and Therapeutics, Medical College of Ohio, 2000-2005
  • Assistant Professor of Pharmacology and Therapeutics, Medical College of Ohio, 1996-1999
  • Research Assistant Professor of Pharmacology and Therapeutics, Medical University of Ohio, 1992-1996
  • Instructor of Pharmacology and Therapeutics, Medical College of Ohio, 1991-1992
  • Postdoctoral Fellow, Departments of Pharmacology and Pathology, Medical University of Ohio, 1990-1991

Research Interests

  • Molecular mechanism of membrane transported-mediated signal transduction
  • Development of novel agonists and antagonists of receptor Na+/K+-ATPase
  • Renal and cardiac physiology of endogenous cardiotonic steroids

Representative Publications