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Faculty Profile

Name: William Price
Title: Associate Professor
Office: Chemistry/COS
Phone: 304-696-3156
Email: pricew@marshall.edu
Expert:
 
Achievements

Research Based:
 
Book Chapters:
W.D. Price, L. Crum‡ and J. Chapman‡, “Hydroiodic Acid Attachment to Basic Residues in the Gas Phase,” Advances in Mass Spectrometry V15, ed by E. Gelpi, John Wiley & Sons, LTD, Chichester (2001).
 
 
Funding:
$5000 Research Challenge Grant Pilot Studies – The Role of Serum Lipoproteins in Hereditary Obesity (Feb 2002)

$4.5 M NSF EPSCoR, “Biomolecular Complexity Infrastructure Award” (Jan 2002 – Jan 2005)

$13,000 NSF EPSCoR, “Proteomics Technician Support” (Oct 2001)

$20,000 NSF EPSCoR, " Establishing Collaboratory Mass Spectrometry Projects Between West Virginia University, Marshall University and State Colleges and High Schools" (Feb 2001)

$30,000 NSF EPSCoR, "Enhancing Nuclear Magnetic Research" January (2001)

$20,000 NSF EPSCoR, "Binding Studies of Naturally Occurring Polyamine and Synthetic Analogues to Oligonucleotides" (May 2001)

$750 West Virginia NASA Space Science Consortium Research Capability Enhancement Mini-Grant (January 2000)

$25,000 Thermoquest Corporation, “Novel Methods for Measuring Step-wise Solvation Energies of Biomolecule Ions” (June 1999)

$2.1 M NSF EPSCoR. “Molecular Characterization and Identification Infrastructure Award” (July 1998 – February 2002).

$1000 West Virginia NASA Space Science Consortium Research Capability Enhancement Mini-Grant (January 1998)

$8600 NASA Marshall University Science Faculty Research Enhancement Award (1997-1998).

 
 
Posters:
G. Gudi, W. D. Price and P. S. Callery, "Oligonucleotide Binding Affinities of Naturally
Occuring Polyamines by Ion Trap Mass Spectrometry," Proceedings of the 49th ASMS
Conference on Mass Spectrometry and Allied Topics, Chicago, Il, June 2001.

G. Gudi, W.D. Price, F.A. Rogers and P.S.Callery, " Noncovalent Interactions of an
Azetidine Analogue of a Polyamine with Oligonucleotides by Ion Trap Mass Spectrometry,"
Proceedings of the 49th ASMS Conference on Mass Spectrometry and Allied Topics,
Chicago, Il, June 2001.

J. Rutherford and W. D. Price, "Kinetic Distinction of the Leucine-Isoleucine Isomers by
ESI-MS with Carboxypeptidase Y," 49th ASMS Conference on Mass Spectrometry and
Allied Topics, Chicago, Il, June 2001.

S. Keshavarzian, J. Chapman and W. D. Price, "Binding of HI to Gas-Phase Basic Sites:
An Ab Initio Study," Proceedings of the 48th ASMS Conference on Mass Spectrometry and
Allied Topics, Long Beach, CA, June 2000.

A. S. Riazi and W. D. Price, "Master Equation Analysis of Ion-Molecule Complexation in
the Zero-Pressure Limit," 219th National Meeting of the American Chemical Society, San
Francisco, CA, 2000.

L. Hicks and W. D. Price, “Questions of Life and Death Explored in the Physical Chemistry
Lab: How and Why Proteins Fold,” 219th National Meeting of the American Chemical
Society, San Francisco, CA, 2000.

S. Keshavarzian and W. D. Price, “Hydroiodic Acid Attachment to Basic residues in the Gas
Phase,” 219th National Meeting of the American Chemical Society, San Francisco, CA,
2000.

W. D. Price and T. Lindbery, “GasPhase Proton Transfer Between Zwitterion and
Protonated Ion: An Experimental and Ab Initio Study,” 218th National Meeting of the
American Chemical Society, New Orleans, LA, 1999.

O. Morgan, W. D. Price, R. J. Morgan, S. Tysoe, T. C. Strekas, and A. D. Baker, “Chiral
Ruthenium(II) Complexes of Modified Phenanthroline Derivatives,” 218th National Meeting
of the American Chemical Society, New Orleans, LA, 1999.

J. Chapman, T. Lindbery and W. D. Price, “Evaluation of Ab Initio Methods for
Determining the Binding Energies of Proton-Bound Dimers,” Proceedings of the 47th ASMS
Conference on Mass Spectrometry and Allied Topics, Dallas, TX, June 1999.

W. D. Price, “Mapping the Ion-Zwitterion Proton Transfer Potential Energy Surface,”
Proceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas,
TX, June 1999.

A. Estes, R. Morrison, L. Meadows and W. D. Price, “The isolation, identification, and
analysis of an analgesic from Clibadium arboreum,” Proceedings of the 47th ASMS
Conference on Mass Spectrometry and Allied Topics, Dallas, TX, June 1999.

J. Dillon, R. J. Morgan, O. V. Morgan, R. J. Donovan and W. D. Price, “New Class of
Chiral Diimine Ligands Derived from Amino Acids,” 217th National Meeting of the
American Chemical Society, Anaheim, CA, 1999.

W.D. Price, R.A. Jockusch and E.R. Williams, “Blackbody Infrared Radiative Processes:
Dissociation and Equilibrium,” Proceedings of the 45th ASMS Conference on Mass
Spectrometry and Allied Topics, Palm Springs, CA, May 1997.

P. D. Schnier, E.F. Strittmatter, J.S. Klassen, W. D. Price and E.R. Williams, “Dissociation
Energetics of DNA and DNA Complexes,” Proceedings of the 45th ASMS Conference on
Mass Spectrometry and Allied Topics, Palm Springs, CA, May 1997.

P. D. Schnier, W. D. Price, D. S. Gross, Y. Zhao and E. R. Williams, “Blackbody Infrared
Radiative Dissociation (BIRD): Binding Energies of Non-Covalent Biomolecule Complexes in
the Gas Phase,” Proceedings of the 44th ASMS Conference on Mass Spectrometry and Allied
Topics, Portland, OR, May 1996.

 
 
Presentations:


W.D. Price, R.A. Jockusch and E.R. Williams, “Experimental and Theoretical Evidence for
Gas Phase Amino Acid Zwitterions,” Proceedings of the 45th ASMS Conference on Mass
Spectrometry and Allied Topics, Palm Springs, CA, June 1997.

W. D. Price, P. D. Schnier, R. A. Jockusch and E. R. Williams, “Blackbody Infrared
Radiative Dissociation: From Dissociation Energetics to Structural Elucidation,” Proceedings
of the 44th ASMS Conference on Mass Spectrometry and Allied Topics, Portland, OR, May
1996.

E. R. Williams, W. D. Price, P. D. Schnier, D. S. Gross, Y. Zhao,and R. A. Jockusch, “The
Role of Charge State on the Conformation and Dissociation Energetics of Biomolecule Ions,”
Proceedings of the 44th ASMS Conference on Mass Spectrometry and Allied Topics,
Portland, OR, May 1996.

W. D. Price, P.D. Schnier and E. R. Williams, “Activation Parameters in the Low Pressure
Limit,” presented at the 1996 Lake Arrowhead Ion Chemistry Conference, Lake Arrowhead,
CA, January 1996.

P. D. Schnier, W. D. Price and E. R. Williams, “Thermal Dissociation of Large Peptide and
Protein Ions,” presented at the 1996 Lake Arrowhead Ion Chemistry Conference, Lake
Arrowhead, CA, January 1996.

(1997, January). Kinetics and energetics of gas-hasle ion dissociation obtained via the blackbocy infrared radiative dissociation technique. Invited speaker at the Oak Ridge National Laboratory, Oak Ridge, TN.

Jockusch, R. A., & Williams, E. R. (1997, May). Blackbody infrared radiative processes: Dissociation and equilibrium. Paper presented at the 45th ASMS Conference on Mass Spectrometry and Allied Topics, Palm Springs, CA.

Jockusch, R. A., & Williams, E. R. (1997, June). Experimental and theoretical evidence for gas phase amino acid zwitterions. Paper presented at the 45th ASMS Conference on Mass Spectometry and Allied Topics, Palm Springs, CA.

(1998, May). Ab initio analysis of gas-phase proton transfer between an ion and zwitterion. Paper presented at the 46th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL.

(1999, June). Mapping the ion-zwitterion proton transfer potentiol energy surface. Paper presented at the 47th ASMS Conference on Mass Spectrometry and Allied Toics, Dallas, TX.

Morgan, R. J., Morgan, O. V., Price, W. D., Donovan, R. J., & Dillon, J. New class of chiral diimine ligands derived from amino acids. Poster session presented at the 217th National Meeting of the American Chemical Society, Anaheim, CA.

Chapman, J., Lindbery, T., & Price, W. D. (1999, June). Evaluation of ad initio methods for determining the binding energies of proton-bound dimers. Poster session presented at the 47th ASMS conference on Mass Spectrometry and Allied Topics, Dallas, TX.

Estes, A., Morriosn, R., Meadows, L. & Price, W. D. (1999, June). The isolation, identificatin, and analysis of an analgesic from Clibadium arboreum. Poster session presented at the 47th ASMS conference on Mass Spectrometry and Allied Topics, Dallas, TX.

& Lindbery, T. (1999). Gas phase proton transfer between zwitterion and protonated ion: An experimental and ab initio study. Poster presented at the 218th National Meeting of the American Chemical Society, New Orleans, LA.

Morgan, O., Price, W. D.,Morgan, R. J., Tysoe, S., Strekas, T. C., & Baker, A. D. (1999). Chiral ruthenium(II) complexes of modified phenanthroline derivatives. Poster session presented at the 218th National Meeting of the American Chemical Society, New Orleans, LA.

(1997, January). Kinetics and energetics of gas-hasle ion dissociation obtained via the blackbocy infrared radiative dissociation technique. Invited speaker at the Oak Ridge National Laboratory, Oak Ridge, TN.

Jockusch, R. A., & Williams, E. R. (1997, May). Blackbody infrared radiative processes: Dissociation and equilibrium. Paper presented at the 45th ASMS Conference on Mass Spectrometry and Allied Topics, Palm Springs, CA.

Jockusch, R. A., & Williams, E. R. (1997, June). Experimental and theoretical evidence for gas phase amino acid zwitterions. Paper presented at the 45th ASMS Conference on Mass Spectometry and Allied Topics, Palm Springs, CA.

(1998, May). Ab initio analysis of gas-phase proton transfer between an ion and zwitterion. Paper presented at the 46th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL.

(1999, June). Mapping the ion-zwitterion proton transfer potentiol energy surface. Paper presented at the 47th ASMS Conference on Mass Spectrometry and Allied Toics, Dallas, TX.

Morgan, R. J., Morgan, O. V., Price, W. D., Donovan, R. J., & Dillon, J. New class of chiral diimine ligands derived from amino acids. Poster session presented at the 217th National Meeting of the American Chemical Society, Anaheim, CA.

Chapman, J., Lindbery, T., & Price, W. D. (1999, June). Evaluation of ad initio methods for determining the binding energies of proton-bound dimers. Poster session presented at the 47th ASMS conference on Mass Spectrometry and Allied Topics, Dallas, TX.

Estes, A., Morriosn, R., Meadows, L. & Price, W. D. (1999, June). The isolation, identificatin, and analysis of an analgesic from Clibadium arboreum. Poster session presented at the 47th ASMS conference on Mass Spectrometry and Allied Topics, Dallas, TX.

& Lindbery, T. (1999). Gas phase proton transfer between zwitterion and protonated ion: An experimental and ab initio study. Poster presented at the 218th National Meeting of the American Chemical Society, New Orleans, LA.

Morgan, O., Price, W. D.,Morgan, R. J., Tysoe, S., Strekas, T. C., & Baker, A. D. (1999). Chiral ruthenium(II) complexes of modified phenanthroline derivatives. Poster session presented at the 218th National Meeting of the American Chemical Society, New Orleans, LA.


 
 
Publications:
S.M. Stevens, R.C. Dunbar, W.D. Price, M. Sena, C. H. Watson, L.S. Nichols, J.M.
Riveros, D.E. Richardson, and J.R. Eyler, “Blackbody Infrared Radiative Dissociation of
Partially Solvated Trisbipyridineruthenium(II) Complex Ions,” J. Phys. Chem A, in press.

W. D. Price, R. A. Jockusch and E. R. Williams, "Structure of Cationized Arginine
(Arg•M+, M = H, Li, Na, K, Rb, Cs) in the Gas Phase: Further Evidence for Zwitterionic
Arginine" J. Phys. Chem A., 1999, 103, 9266-9274.

W.D. Price, R. A. Jockusch and E. R. Williams, “Binding Energies of Protonated Betaine
Complexes: A Probe of Zwitterion Structure in the Gas Phase” J. Am. Chem. Soc., 1998,
120, 3474-3484.

W.D. Price and E.R. Williams, “Activation of Peptide Ions by Blackbody Radiation: Factors
Which Lead to Dissociation Kinetics in the Rapid Energy Exchange Limit” J. Phys. Chem.
A, 1997, 101, 8844-8852.


W.D. Price, R. A. Jockusch, P.D. Schnier and E. R. Williams, “Does Arginine Exist as a
Zwitterion in the Gas Phase?” J. Am. Chem. Soc., 1997, 119, 11988-11989.

P.D. Schnier, W.D. Price, E. F. Strittmatter and E. R. Williams, “Dissociation Energetics
and Mechanisms of Leucine Enkaphalen (M + H)+ and (2M + H)+ Ions (X = H, Li,Na, K, an
Rb) Measured by Blackbody Infrared Radiative Dissociation,” J. Am. Soc. Mass Spectrom.,
1997, 8, 771-780.

W. D. Price, P. D. Schnier and E. R. Williams, “Binding Energies of the Proton Bound
Amino Acid Dimers Gly•Gly, Ala•Ala, Gly•Ala and Lys•Lys Measured by Blackbody Infrared
Radiative Dissociation,” J. Phys. Chem. B, 1997, 101, 664-673.

R. A. Jockusch, P. D. Schnier, W. D. Price, E. F. Strittmatter, P. A. Demirev and E. R.
Williams, “Effects of Charge State on Fragmentation Pathways, Dynamics and Activation
Energies of Ubiquitin Ions Measured by Blackbody Infrared Radiative Dissociation,” Anal.
Chem., 1997, 69, 1119-1126.

Schnier, P. D., & Williams, E. R. (1996). Tandem mass spectrometry of large biomolecule ions by blackbody infrared radiative dissociation. Analytical Chemistry, 68, 859-866.

Schnier, P. D., Price, W. D., & Williams, E. R. (1996). Modeling the maximum charge state of arginine-containing peptide ions formed by electrospray ionization. Journal of the American Society for Mass Spectrometry, 7, 972-976.

Schnier, P. D., Price, W. D., Jockusch, R. A., & Williams, E. R. (1996). Blackbody infrared radiative dissociation of brandykinin and its analogues—energetics, dynamics, and evidence for salt-bridge structures in the gas phase. Journal of the American Chemical Society, 118, 7178-7189.

Schnier, P. D., Jockusch, R. A., Strittmatter, E. F., & Williams, E. R. (1996). Unimolecular reaction kinetics in the high-pressure limit without collisions. Journal of the American Chemical Society, 118, 10640-10644.

Jockusch, R. A., Schnier, P. D., Price, W. D., Strittmatter, E. F., Demirev, P. A., & Williams, E. R. (1997). Effects of charge state on fragmentation pathways, dynamics and activation energies of ubiquitin ions measured by blackbody infrared radiative dissociation. Analytical Chemistry, 69, 1119-1126.

Schnier, P. D., & Williams, E. R. (1997). Binding energies of the proto bound amino acid dimers Gly•Gly, Ala•Ala, Gly•Ala and Lys•Lys measured by blackbody infrared radiative dissociation. Journal of Physical Chemistry B, 101, 664-673.

Schnier, P. D., Price, W. D., Strittmatter, E. F., & Williams, E. R. (1997). Dissociation energetics and mechanisms of leucine enkaphalen (M + H)+ and (2M + H)+ions (X = H, Li,Na,K, and Rb) measured by blackbody infrared radiative dissociation. Journal of the American Society for Mass Spectrometry, 8, 771-780.

Jockusch, R. A., Schnier, P. D., & Williams, E. R. (1997). Does arginine exist as a zwitterion in the gas phase? Journal of the American Chemical Society, 119, 11988-11989.

& Williams, E. R. (1997). Activation of peptide ions by blackbody radiation: Factors which lead to dissociation kinetics in the rapid energy exchange limit. Journal of Physical Chemistry A, 101, 8844-8852.

Jockusch, R. A. & Williams. E. R. (1998). Binding energies of protonated betaine complexes: A probe of zwitterion structure in the gas phase. Journal of the American Chemical Society, 120, 3474-3484.

Jockusch, R. A., & Williams, E. R. (1999). Structure of cationized arginine (Arg•M+, M = H, Li, Na, K, Rb, Cs) in the gas phase: Further evidence for zwitterioinic arginine. Journal of Physical Chemistry A., 103, 9266-9274.


W. D. Price, P. D. Schnier, R. A. Jockusch, E. F. Strittmatter and E. R. Williams,
“Unimolecular Reaction Kinetics in the High-Pressure Limit Without Collisions,” J. Am.
Chem. Soc., 1996, 118, 10640-10644.

P. D. Schnier, W. D. Price, R. A. Jockusch and E. R. Williams, “Blackbody Infrared
Radiative Dissociation of Bradykinin and Its Analogues - Energetics, Dynamics, and Evidenc
for Salt-Bridge Structures in the Gas Phase,” J. Am. Chem. Soc., 1996, 118, 7178-7189.

P.D. Schnier, W. D. Price and E. R. Williams, “Modeling the Maximum Charge State of
Arginine-Containing Peptide Ions Formed by Electrospray Ionization,” J. Am. Soc. Mass
Spectrom., 1996, 7, 972-976.

W. D. Price, P. D. Schnier and E. R. Williams, “Tandem Mass Spectrometry of Large
Biomolecule Ions by Blackbody Infrared Radiative Dissociation,” Anal. Chem., 1996, 68,
859-866.

 
 
Seminars:
"Teaching Mass Spectrometry Across the Upper Division Chemistry Curriculum: Structured
Laboratories and Open Access," 49th ASMS Conference on Mass Spectrometry and Allied
Topics, Chicago, Il, June 2001. (Keynote Lecture)

“Investigations of Biomolecular Complexity at Marshall University," Eighth Annual West
Virginia EPSCoR State Conference, Charleston, WV, February 2001.

"The Evolution of Molecular Complexity Explored with Computers and Mass
Spectrometers." New Mexico Tech, Socorro, New Mexico, October 2000.

"Toward Understanding the Role of Proton Transfer Reactions in Protein Conformations," Los
Alamos National Laboratory, Los Alamos, New Mexico, October 2000.

"The Nature of Hydroiodic Attachment to Basic Peptide Residues in the Gas Phase," 15th
International Mass Spectrometry Conference, Barcelona, Spain, August 2000.

"Mass Spectrometry, Computations, and the Machinery of Life," New Mexico Highlands
University, Las Vegas, New Mexico, March 2000.

“Undergraduate Research in Identification Technologies,” Seventh Annual West Virginia
EPSCoR State Conference, Charleston, WV, February 2000.

“Ions, Molecules and Computational Techniques,” Oak Ridge National Laboratory, Oak
Ridge, TN, October 1999.

“Mass Spectrometry and Prospecting for Natural Products in the Tropical Rain Forest,” 51st
Southeast Regional Meeting of the American Chemical Society, Knoxville, TN, October
1999.

“Computational Methods for Exploring Gas Phase Ion Chemistry,” 47th ASMS Conference
on Mass Spectrometry and Allied Topics, Dallas, TX, June 1999.

“Role of Mass Spectrometry in Biomedical Research,” Marshall University School of
Medicine, April, 1999.

“Structure and Reactivity of Gas-Phase Biomolecule Ions,” Joint Meeting of the Central Ohio
Valley and Kanawa Valley Sections of the American Chemical Society, Charleston, WV
October, 1997.

"Kinetics and Energetics of Gas-Phase Ion Dissociation Obtained Via the Blackbody Infrared
Radiative Dissociation Technique" Oak Ridge National Laboratory, Oak Ridge, TN, January
1997.




 

Awards:
 
Awards
American Society for Mass Spectrometry Young Investigator Award, June 1999.

Includes an unrestricted cash award of $25 K for research.

 

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