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Faculty Profile

Name: Richard Niles
Title: Professor and Chair
Office: Biochemistry and Molecular Biology/SOM
Phone: 304-696-7323
Email: niles@marshall.edu
Expert:
 
Achievements

Research Based:
 
:
Desai, S., and Niles, R.M. Characterization of Retinoic Acid-Induced AP-1 Activity in B16 Melanoma Cells. J. Biol. Chem. 272: 12809-12815, 1997.

Klinge, C.M., Bodenner, D.L., Desai, D., Niles, R.M., and Traish, A.M. Binding of Type II Nuclear Receptors and Estrogen Receptor to Full and Half-Site Estrogen Response Elements in vitro. Nucleic Acids Res. 25: 1903-1912, 1997.

Wang, S., Desai, D., Wright, G., Niles, R.M., and Wright, G.L. Effects of Protein Kinase C a Overexpression on A7r5 Smooth Muscle Cell Proliferation and Differentiation. Exp. Cell Res. 236: 117-126, 1997.

Mahalingam, H., Watanabe, A., Tachibana, M., and Niles, R.M. Characterization of Density-Dependent Regulation of the Tyrosinase Gene Promoter: Role of Protein Kinase C. Exp. Cell Res. 237: 83-92, 1997.

Niles, R.M. Control of Retinoid Nuclear Receptor Function and Expression. In Subcellular Biochemistry, Vol. 30: Fat-Soluble Vitamins, pp. 3-28, Quinn and Kagan eds. Plenum Press, New York, 1998.

Desai, D.S., Hirai, S-i., Karnes, Jr., W.E., Niles, R.M., and Ohno, S. Cloning and Characterization of the Murine PKC promoter; Identification of a Retinoic Acid Response Element. Biochem. Biophys. Res. Comm. 263: 28-34, 1999.

Desai,S.H., Boskovic, G., Eastham,L., Dawson,M., and Niles, R.M. Effect of Receptor-Selective Retinoids on Growth and Differentiation Pathways in Mouse Melanoma Cells. Biochem. Pharmacol. 59: 1265-1275, 2000.

Niles, R.M. Recent Advances in the Use of Vitamin A (Retinoids) in the Prevention and Treatment of Cancer. Nutrition 16: 1084-1089, 2000.

Niles, R.M. Vitamin A and Cancer. Nutrition 16: 573-576, 2000.

Geng, W.D., Boskovic, G., Fultz, M.E., Niles, R.M., Ohno, S., and Wright, G.L. Regulation of Expression and Activity of Four PKC Isozymes in Confluent and Mechanically Stimulated UMR-108 Osteoblastic Cells. J. Cell. Physiol. 189: 216-228, 2001.

Niles, R.M. The Use of Retinoids in the Prevention and Treatment of Skin Cancer. Expert Opin. Pharmacother. In Press.


 
 
Book Chapters:
(1998). Control of retinoid nuclear receptor function and expression. In R. Quinn & V. Kagan (Eds.), Subcellular Biochemistry, Vol. 30: Fat-Soluble Vitamins (pp. 3-28). New York: Plenum Press
 
 
Funded Grants:
(1996-1999). Retinoids and Protein Kinase C in Melanoma Differentiation. National Institutes of Health (NCI), principal investigator, $421,134

 
 
Presentations:
(1996, October). PKC and Melanogenesis CBRC. Presented at Massachusettes General Hospital, Charlestown, MA.

(1996, October). Retinoids and PKC in Melanoma Differentiation. Presented at the Department of Biochemistry, Boston University School of Medicine, Boston, MA.

(1997, December). Control of Melanoma Growth and Differentiation by Retinoids. Presented at National Cancer Institute, Bethesda, MD.

(1998, February). Retinoids and Melanoma Differentiation. Presented at Wake Forest University Comprehensive Cancer Center, Winston-Salem, NC.

(1998, April). Regulation of Melanoma Growth and Differentiation by Retinoids. Washington State University, Pullman, WA.

(1998, November). Induction of Melanoma Differentiation by Vitamina A (Retinoids). Presented at University of Osteopathic and Health Sciences, Des Moines, Iowa.

(1999, March). Control of Melanoma Growth and Differentiation by Vitamin A (Retinoids). Presented at West Virginia University Health Sciences Center, Morgantown, WV.

(1999, March). Role of Protein Kinase C in the Induction of Melanoma Differentiation by Retinoids. Presented at the University of Louisville, Louisville, KY.

(1999, April). Regulation of Melanoma Growth and Differentiation by Retinoids. Presented at the Southern Research Institute, Birmingham, AL.

(1999, May). Involvement of PKC in the Regulation of Melanoma Proliferation and Differentiation by Vitamin A (Retinoids). Presented at Cornell University, Ithaca, NY.
 
 
Publications:
(1996-1999). Retinoids and Protein Kinase C in Melanoma Differentiation. National Institutes of Health (NCI), principal investigator, $421,134

 
 
Publications:
Xiao, Y., Desai, D., Quick, T. C., & Niles, R. M. (1996). Control of retinoic acid receptor expression and function in mouse melanoma by cyclic AMP. Journal of Cellular Physiology 167, 413-421.

& Combs, R. (1996). The relationship between susceptibility to retinoic acid treatment and protein kinase cµ expression in murine melanoma cell lines. Experimental Cell Research. 223, 21-28.

Huijzer, J. C., McFarland, M., Niles, R. M., & Meadows, G. G. (1996). Phorbol 12-myristate 13-acetate enhances nm23 gene expression in murine melanocytes, but not in syngeneic B16-BL6 melanoma variants. Journal of Cellular Physiology 166, 487-494.

Desai, D., Michalak, M., Singh, N. K., & Niles, R. M. (1996). Inhibition of retinoic acid receptor function and retinoic acid-regulated gene expression in mouse melanoma cells by calreticulin: A potential pathway for cyclic AMP regulation of retinoid action. Journal of Biological Chemistry, 271, 15153-15159.

Mahalingam, H., Vaughn, J., Novotny, J., & Gruber, J. R. (1996). Regulation of melanogenesis in B16 mouse melanoma cells by protein kinase C. Journal of Cellular Physiology, 168, 549-558.

Desai, S., & Niles, R. M. (1997). Characterization of retinoic acid-induced AP-1 activity in B16 melanoma cells. Journal of Biological Chemistry, 272, 12809-12815.

Klinge, C. M., Bodenner, D. L., Desai, D., Niles, R.M., & Traish, A.M. (1997). Binding of type II nuclear receptors and estrogen receptor to full and half-site estrogen response elements in vitro. Nucleic Acids Research, 25, 1903-1912.

Wang, S., Desai, D., Wright, G., Niles, R.M., & Wright, G. L. (1997). Effects of protein kinase C overexpression on A7r5 smooth muscle cell proliferation and differentiation. Experimental Cell Research, 236, 117-126.

Mahalingam, H., Watanabe, A., Tachibana, M., & Niles, R. M. (1997). Characterization of density dependent regulation of the tyrosinase gene promoter: Role of protein kinase C. Experimental Cell Research, 237, 83-92.
 

Professional/Community Based Service:
 
:
Session Chair: Retinoids and Cell Differentiation, American Association for Cancer Research Meeting, Washington, D.C. April, 1996.

Organized and Chaired Session on “Resveratrol in Cancer Prevention and Treatment” for 9th AICR Annual Research Conference, Washington, D.C., 1999.

Organized and Chaired Session on “Vitamins, Antioxidants and Trace Elements in Breast and Prostate Cancer Prevention and Treatment” for 10th AICR Annual Research Conference, Washington, D.C., 2000.

Member of Steering Committee for the Nutrition-Gene Interaction Research Interest Section of the American Society for Nutritional Sciences.

Chair for Mini-Symposum “Genomics and Nutrition," Experimental Biology 2001 (ASNS), Orlando, FL, April, 2001.

Organized and Chaired Session on “Molecular Action of Nutrients in Cancer Prevention” for the 11th AICR Annual Research Conference. Washington, D.C., July, 2001.
 

Awards:
 

Principal Investigator: Retinoids and Protein Kinase C in Melanoma Differentiation. NIH (NCI. $421,134 - 4/1/96 - 3/31/99.

Co-Investigator: (PI Dr. Gary Rankin, Chair of Pharmacology, Marshall University School of Medicine)
Chemical-Induced Nephrotoxicity: Succinimides. NIH. $1,152,124 - 4/01/98 - 03/31/03.

Principal Investigator: Induction of Melanoma Differentiation by Retinoic Acid: Early Response Genes
AICR. $164,835 – 1/1/00 – 12/31/01.

Principal Investigator: Retinoids and Protein Kinase C in Melanoma Differentiation. NIH. $1,050,000 – 4/1/00 – 3/31/05.

Obtained Burroughs-Wellcome Visiting Professorship Award for Department of Biochemistry & Molecular Biology At Marshall University to sponsor Dr. Daria Mochly-Rosen from Stanford University, Nov. 2000.

Co-Investigator: Molecular Sciences. NSF-EPSCoR. $3,000,000 – 1/1/02 – 12/31/04.

“Researcher of the Year Award” 1999-2000 Sigma Xi – Marshall University Chapter.

Alumni Achievement Award - 2001. Rhode Island College, Providence, RI.

 

Other Achievements:
 
Invited Seminars:
Regulation of Melanoma Growth and Differentiation by Retinoids Washington State University, Pullman, WA., April, 1998.

Induction of Melanoma Differentiation by Vitamina A (Retinoids)University of Osteopathic and Health Sciences
Des Moines, Iowa, Nov., 1998.

Control of Melanoma Growth and Differentiation by Vitamin A (Retinoids)West Virginia University Health Sciences Center, Morgantown, WV, March, 1999.

Role of Protein Kinase C in the Induction of Melanoma Differentiation by Retinoids University of Louisville
Louisville, KY, March, 1999.

Regulation of Melanoma Growth and Differentiation by Retinoids, Southern Research Institute, Birmingham, AL, April, 1999.

Involvement of PKC in the Regulation of Melanoma Proliferation and Differentiation by Vitamin A (Retinoids)
Cornell University, Ithaca, NY, May, 1999.

Regulation of Melanoma Growth and Differentiation by Retinoids and Protein Kinase C, Department of Biochemistry, Wake Forest University School of Medicine
Winston-Salem, NC, Sept. 1999.

Opportunities for Biotechnology Industry in the Tri-State Area, Huntington Rotary Club, Huntington, WV, May 2000.

Identification of Retinoid-Regulated Genes in Melanoma Cells Through the Use of DNA Arrays, Experimental Biology Meeting, Orlando, FL, March, 2001.

Retinoic Acid and Protein Kinase C: Role in Melanoma Growth and Pigmentation, Avon, Inc., Corporate Research
Suffern, NY, April, 2001.

Identification of the Transcription Factor Tbx2 as a Vitamin A-Regulated Gene in Mouse Melanoma Cells
AICR Annual Research Conference on Nutrition and Cancer
Washington, D.C., July, 2001.

Vitamin A (Retinoids) Regulation of Melanoma Growth and Differentiation, University of Southern Maine/Maine Medical Center Research Institute, Portland, ME, Oct., 2001.
 
 
Peer Review:
Member Special Review Committee for SCOR NHLBI, NIH, March 1996.

Member Pathobiology Review Panel for US Army Breast Cancer Research Program, Sept. 1995, 1996, 1997, 1998.

Appointed Chair of Pathobiology Review Panel for US Army Breast Cancer Research Program, 1999, 2000.

Member, Special Review Panel for US Army Breast Cancer “Concept” Grant Program, May 2000.

Ad hoc reviewer for NIH Metabolic Pathology Study Section, Nov., 2000, Feb, 2001.

Permanent member NIH Metabolic Pathology Study Section, June, 2001.
 

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