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Faculty Profile

Name: Monica Valentovic
Title: Professor
Office: Pharmacology/SOM
Phone: 304-696-7332
Email: valentov@marshall.edu
Expert:
 
Achievements

Research Based:
 
Abstracts:
M.A. Valentovic, J.G. Ball and B.A. Rogers. Comparison of cephaloridine in vitro renal toxicity between normoglycemic and diabetic rats. Toxicologist 30:306-307, 1996.

S.-K. Hong, D.K. Anestis, L.D. Dial, M.A. Valentovic, J.G. Ball and G.O. Rankin. Effect of ascorbic acid and acivicin on 4-amino-2,6-dichlorophenol (ADCP)-induced nephrotoxicity in the Fischer 344 rat. Toxicologist 30:306, 1996.

N.M. Hawco, M.A. Valentovic, and G.O. Rankin. Effect of hepatic S9 fraction coincubation with renal cortical slices on N-(3,5-dichlorophenol)succinimide (NDPS) and
NDPS metabolite nephrotoxicity. Toxicologist 30:308, 1996.

G.O. Rankin, S.K. Hong, D.K. Anestis, C.C. Skaggs, J.B. Ball, and M.A. Valentovic. N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in GUNN rats. Toxicologist 36:145, 1997.

D.K. Anestis, S.K. Hong, J.G. Ball, M.A. Valentovic, and G.O. Rankin. Dose dependent effect of sodium sulfate on N-(3,5-dichlorophenyl)succinimide (NDPS) nephrotoxicity.
Toxicologist 36:146, 1997

S.K. Hong, D.K. Anestis, J.B. Ball, M.A. Valentovic, and G.O. Rankin. A role for leukotrienes in N-(3,5-dichloro-phenyl)succinimide (NDPS) metabolite nephrotoxicity in
Fischer 344 rats. Toxicologist 36:146, 1997.

M.A. Valentovic, J.G. Ball, S.K. Hong, and G.O. Rankin. In vitro nephrotoxicity of 2- and 4-chloroaniline: comparisons with 4-amino-3-chlorophenol, 2-amino-5-chlorophenol and aminophenols. Toxicologist 36:146, 1997.

J.B. Ball, R.C. Harmon, and M.A. Valentovic. Differences in renal cephaloridine toxicity and accumulation following insulin pretreatment of diabetic rats. Toxicologist 36:148, 1997.

S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic, and G.O. Rankin. NDPS and NDPS metabolite nephrotoxicity in Wistar rats. Toxicologist 42:376, 1998.

M.A. Valentovic, J.G. Ball, and R.C. Harmon. 3,4-Dichloroaniline toxicity in renal cortical slices from Fischer 344 rats. Toxicologist 42:376, 1998.

M.A. Valentovic, J.G. Ball and G.O. Rankin. 2-amino-5-chlorophenol toxicity in rat renal cortical slices: effect of antioxidants. Toxicologist 43:28, 1999.

G.O. Rankin, S.K. Hong, D.K. Anestis, J.G. Ball and M.A. Valentovic. Phenobarbital potentiates N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-
dichlorophenylsuccinamic acid (2-NDHSA) nephrotoxicity in male but not female Fischer 344 rats. Toxicologist 43:28, 1999.

S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic and G.O. Rankin. Sodium sulfate potentiates N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-
dichlorophenylsuccinamic acid (2-NDHSA) nephrotoxicity in Fischer 344 rats. Toxicologist 43:28, 1999.

M.A. Valentovic, J.G. Ball and G.O. Rankin. 2-Amino-4,5-dichlorophenol (2A45CP) toxicity in renal cortical slices from Fischer 344 rats. Toxicologist 54:404, 2000.

G.O. Rankin, S.K. Hong, D.K. Anestis, J.G. Ball and M.A. Valentovic. Attenuation of 4-amino-2,6-dichlorophenol nephrotoxicity in renal cortical slices by ascorbate, aminooxyacetic acid, indomethacin and gluathione. Toxicologist 54:404, 2000.

S.L. Miles, S.K. Hong, O. Noe, D.K. Anestis, M.A. Valentovic, J.G. Ball and G.O. Rankin. Evidence for nephrotoxic sulfate conjugates of N-(3,5-dichlorophenyl)succinimide metabolites. Toxicologist 54:503, 2000.

M.A. Valentovic, J.G. Ball. 3,4-Dichlorophenylhydroxylamine induced alterations in rat
renal cortical slices: The effect of antioxidants and sulfhydryl agents. Presented at Contemporary Concepts in Toxicology: Mechanisms of Nephrotoxicity and
Nephrocarcinogenicity April 15-18 Martha’s Vineyard, MA.

J. Minigh and M.A. Valentovic. Effects of myoglobin on renal cortical slices from Fischer 344 rats. Toxicologist 60:309, 2001.

MA. Valentovic, J.G. Ball, N.F. Alejandro and K.S. Ramos. Renal effects of Benzo(a)pyrene in diabetic rats. Toxicologist 60:310, 2001.

S.L. Miles, D.K. Anestis, J.G. Ball, M.A. Valentovic and G.O. Rankin. Effects of N-(3,5-dichlrophenyl)succinimide (NDPS) metabolites on adenosine nucleotide levels in isolated rat renal cortical epithelial cells. Toxicologist 60:310, 2001.

G.O. Rankin, D.K. Anestis, S.K. Hong, J.G. Ball and M.A. Valentovic. Effect of diuresis on N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity
in Fischer 344 rats. FASEB J. 15 (4), A236 (212.1), 2001.

 
 
Publications (peer reviewed):
M.A. Valentovic, J.G. Ball and B.A. Rogers. Comparison of cephaloridine renal accumulation and urinary excretion between normoglycemic and diabetic animals. Toxicology 108:93-99, 1996.

G.O. Rankin, K.W. Beers, D.W. Nicoll, D.K. Anestis, S.K. Hong, J.L. Hubbard, J.G. Ball, M.A. Valentovic, and P.I. Brown. Nephrotoxic potential of 2-amino-5-chlorophenol and 4-amino-3-chlorophenol: Comparisons with 2- and 4- chloroaniline and 2- and 4- aminophenol. Toxicology 108:109-123, 1996.

S.K. Hong, D.K. Anestis, N.M. Hawco, M.A. Valentovic, P.I. Brown and G.O. Rankin. Nephrotoxicity of N-(3-bromophenyl)-2-hydroxy-succinimide: role of halogen groups in the nephrotoxic potential of N-(halophenyl)succinimides. Toxicology 110:17-25, 1996.

S.K. Hong, M.A. Valentovic, D.K. Anestis, J.G. Ball, P.I. Brown and G.O. Rankin. Nephrotoxicity of 4-amino-2-chlorophenol and 2-amino-4-chlorophenol in the Fischer 344 rat. Toxicology 110:47-58, 1996.

M.A. Valentovic, J.G. Ball, S.K. Hong, B.A. Rogers, M.K. Meadows, R.C. Harmon and G.O. Rankin. In vitro toxicity of 2- and 4-chloroaniline: comparisons with 4-amino-3-
chlorophenol, 2-amino-5-chlorophenol and aminophenol. Toxicology In Vitro 10:713-720, 1996.

M.A. Valentovic, T. Yahia, J.G. Ball, S.K. Hong and G.O. Rankin. 3,4-Dichloroaniline acute toxicity in Fischer 344 rats. Toxicology 124; 125-134, 1997.

M.A. Valentovic, B.A. Rogers, M.K. Meadows, J.T. Conner, E. Williams, S.K. Hong and G.O. Rankin. Characterization of methemoglobin formation induced by 3,5-dichloroaniline,
4-amino-2,6-dichlorophenol and 3,5-dichlorophenyl-hydroxylamine Toxicology 118:23-36, 1997.

M.A. Valentovic, J.G. Ball, B.A. Rogers, M.K. Meadows, R.C. Harmon and J. Moles. Cephaloridine in vitro toxicity and accumulation in renal slices from normoglycemic and
diabetic rats. Fund. Appl. Toxicol. 38: 184-190, 1997.

S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic, P.I. Brown and G.O. Rankin. 4-Amino-2,6-dichlorophenol (ADCP) nephrotoxicity in the Fischer 344 rat: Protection by
ascorbic acid, AT-125 and aminooxyacetic acid. Toxicol. Appl. Pharmacol. 147: 115-125, 1997.

M.A. Valentovic and J.G. Ball. 2-Aminophenol and 4-aminophenol toxicity in renal slices from Sprague Dawley and Fischer 344 rats. J Toxicology Environ. Health. 55(3):225-240, 1998.

S.K. Hong, D.K. Anestis, M.A. Valentovic, J.G. Ball, P.I. Brown, R.T. Wang and G.O.Rankin. Gender differences in acute N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS)
and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (NDHSA) nephrotoxicity in Fischer 344 rats. J Toxicol Environ Health 54(8):613-32, 1998.

D.G. Lister, J. Carl III, J.H. Morgan, D.A. Denning, M.Valentovic, B. Trent, B.L. Weaver. Pediatric all-terrain vehicle trauma: a 5 year statewide experience. J Pediatric Surg. 33(7):1081-3, 1998.

S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic, P.I. Brown and G.O. Rankin. Effect of glucuronidation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Fischer 344 rats. Toxicology 132:43-55, 1999.

J.L. Hubbard, O. Noe II, M. Egermayer, S.K. Hong, D.K. Anestis, M.A. Valentovic, J.G. Ball and G.O. Rankin. Nephrotoxic potential of N-(3,5-dichloro-4-fluorophenyl) succinimide in Fischer 344 rats: Comparison with N-(3,4,5-trichlorphenyl)succinimide. Toxicology 132:119-125, 1999.

S.K. Hong, D.K. Anestis, J.G. Ball, M. A. Valentovic, P.I. Brown and G.O. Rankin. Effect of sulfation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Fischer 344 rats. J. Toxicol. Environ. Health Part A 57:47-62, 1999.

M.A. Valentovic, M.K. Meadows, R.C. Harmon, J.G. Ball, S. Stohl, S.K. Hong and G.O. Rankin. 2-Amino-5-chlorophenol toxicity in renal cortical slices from Fischer 344 rats:
Effects of antioxidants and sulfhydryl agents. Toxicol. Appl. Pharmacol. 161: 1-9, 1999.

S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic, P.I. Brown and G.O. Rankin. Sodium sulfate potentiates N-(3,4-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in the Fischer 344 rat. Toxicology 138(3): 165-74, 1999.

M.A. Valentovic, J.G. Ball, S. Stoll and G.O. Rankin. 3,4-Dichlorophenylhydroxylamine cytotoxicity in renal cortical slices from Fischer 344 rats. Toxicology 162(3): 149-156, 2001.

S.K. Hong, D.K. Anestis, M.A. Valentovic, J.G. Ball, P.I. Brown and G.O. Rankin. Gender differences in the potentiation of N-(3,5-dichlorophenyl)sucinimide metabolite nephrotoxicity by Phenobarbital. J Toxicol Environ Health 64(3): 241-256, 2001.

G.O. Rankin, H. Sun, D.K. Anestis, O. Noe, J.G. Ball, M.A. Valentovic, P.I. Brown and J. L. Hubbard. Role of stereochemistry in N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity. Toxicology 168: 241-250, 2001.

G.O. Rankin, S.K. Hong, D.K. Anestis, T.T. Henderson, J.G. Ball, M.A. Valentovic and P.I. Brown. Effect of three N-acetylamino acids on N-(3,5-dichlorophenyl)succinimide (NDPS)and NDPS metabolite nephrotoxicity in Fischer 344 rats. J. Toxicol. Environ Health J Toxicol. Environ. Health 65:539-556, 2002.

S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic, G.O. Rankin. In vitro nephrotoxicity induced by chloronitrobenzenes in renal cortical slices from Fischer 344 rats. 129:133-141, 2002.

M.A. Valentovic, J.G. Ball, H. Sun and G.O. Rankin. Characterization of 2-amino-4,5-dichlorophenol (2A45CP) In Vitro Toxicity in Renal Cortical Slices from Male Fischer 344 rats. Toxicology 172 (2): 113-123, 2002.
 

Professional/Community Based Service:
 
Society of Toxicology (SOT):
SOT, In Vitro Specialty Section, Councilor 1998-2001.
SOT, In Vitro Specialty Section, Vice President Elect, 2000-2001.
SOT, In Vitro Specialty Section, Vice President, 2001-present.
SOT New Investigator Forum, 1990.
In Vitro Specialty Section, Judge for Outstanding Graduate Student Abstract 1999, 2000, 2001.
Mechanisms Specialty Section, Judge for Outstanding Graduate.
Student Manuscript, 2000.
 

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