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Faculty Profile

Name: Philippe Georgel
Title: Associate Professor
Office: Biological Sciences/COS
Phone: 304-696-3965
Email: georgel@marshall.edu
Expert: Molecular Biology
 
Achievements

Creative Works:
 1. Spring 2003. Energy requirement for nucleosome sliding (NASA: West Virginia Space Grant Consortium, $2,000).
2. Fall 2004: New models for the role of chromatin in controlling inducible gene transcription. Co-PI with Dr. Frances Shannon (Australian Research Corporation), no compensation.
3. Fall 2004-Spring 2005: Investigation of GAGA transcription factor binding on DNA path and chromatin condensation (NASA: West Virginia Space Grant Consortium, $4,000).
4. Spring 2005-present: Chromatin regulation of mucous phenotype in rat/mouse salivary glands. (Seed grant awarded through the COBRE program at Marshall University School of Medicine; initial installment: $20,000 plus extension: $20,000).
5. Summer 2005: GAGA factor and chromatin. (SURE program, Marshall University, $4,500).
6. May 2006-April 2007: Establishment of an Integrated Cell Differentiation and Development Research Unit. (WV EPSCoR Research Group Initiation, PIs: Georgel, P.T and Blough E, Marshall University, $50,000).
7. May 2006-April 2007: Inter-disciplinary grant (NASA WV Space Consortium, PIs: Blough E, Georgel, P.T, $63,500).
8. May 2006- April 2009: Next Generation Biometrics: Achieving Strength in Molecular Recognition and Transport (National science Foundation EPSCoR, PI: Hill, P. Co-investigator, Georgel, P.T. Marshall University, $ 8,999,903)


 

Research Based:
 
:
Publications

1. Vacuum UV Circular Dichroism and Molecular Modeling Yields a Structure for Changes in the Binding Region of Tat Complexed with HIV-1 RNA+. Loret, E.P., Georgel, P., Johnson, W.C., Ho, P.S. Proceeding National Academy of Science. USA. Vol. 89. pp 9734-9738 (1992).
2. Binding of the RNA Polymerase I Transcription Complex to its Promoter Core Can Modify Positioning of Downstream Nucleosomes Assembled in Vitro. Georgel, P., Demeler, B., Terpening, C., Paule, M.P., van Holde, K.E. Journal of Biological Chemistry. Vol. 268 (3). pp 1947-1954 (1993).
3. Role of Histone Tails in Nucleosome Remodeling by Drosophila NURF. Georgel, P.T., Tsukiyama, T. and Wu, C. EMBO Journal. Vol. 16 (15).pp 4717-4726 (1997).
4. ATP-dependent Remodeling of Chromatin. Wu, C., Tsukiyama, T., Gdula, D., Georgel, P., Martinez-Balbas, M., Mizuguchi, G., Ossipow, V., Sandaltzopoulos, R. and Wang, H-M. Cold Spring Harbor Symposia on Quantitative Biology. Vol. LXIII. pp 525-534 (1998).
5. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Carrier, F, Georgel, P.T., Pourquier, P., Blake, M., Udo Konty, H., Antinore Jr., M.J., Gariboldi, M., Myers, T.G., Weinstein, J., Pommier, Y. and Fornace Jr., A.J. Molecular and Cell Biology. Vol.19 (3). pp 1673-1685 (1999).
6. Sir3p-dependent assembly of chromatin suprastructure in vitro. Georgel, P.T., Debeer, M.A., Pietz, G., Fox, C.A. and Hansen, J.C. P.N.A.S. USA. Vol. 98 (15). pp 8584-8589 (2001).
7. Differential core histone binding behavior: RNA polymerase I promoter region vs. 5S rDNA positioning DNA sequences. Georgel P.T. and Robert, C.H. Cell Biochemistry and Biophysics. Vol 37 (1). pp 1-13 (2002).
8. Formation of higher order secondary and tertiary chromatin structures by genomic mouse mammary tumor virus promoters. Georgel, P.T, Fletcher, T., Hager, G. and Hansen, J.C. Genes and Development. Vol. 17 (13). pp1617-29 (2003).
9. Quantitative Characterization of Specific Genomic Promoters Using Agarose Gel Electrophoresis. Georgel, P.T. and Hansen, J.C. invited article for Biopolymers. Vol. 68. pp 557-562 (2003).
10. Chromatin Compaction by Human MeCP2: Assembly of novel secondary chromatin structures in the absence of DNA methylation. Georgel, P.T, Horowitz, R.A., Woodcock, C.L., Adkins, N.L., Wade, P.A. and Hansen, J.C. Journal of Biological Chemistry. Vol. 278 (34). pp 32181-32188 (2003).
11. The sld mutation is specific for sublingual salivary mucous cells and disrupts apomucin gene expression. Fallon, M.A, Latchney, L.R., Hand, A.R., Denny, P.A., Georgel, P.T., Denny, P.C. and Culp, D.J. Physiological Genomics. Vol 14 (2). pp 95-106 (2003).
12. Determinants of the chromatin remodeling effect induced by the GAGA transcription factor on Drosophila hsp70 gene. Georgel, P.T. Biochemistry and Cell Biology. Vol. 83 (4). pp 555-565 (2005)
13. HDAC1 acetylation is linked to progressive modulation of steroid receptor induced gene transcription. Qiu,Y., Zhao,Y., Becker,M., John,S., Parekh,B.S., Huang,S., Hendarwanto,A., Martinez,E.D., Chen,Y., Lu,H., Adkins,N.L., Stavreva,D.A., Wiench,M., Georgel,P.T., Schiltz,R.L., and Hager,G.L. (Molecular Cell. June 9, 2006).
14. Characterization of chromatin samples in the presence of Drosophila embryo extract by Quantitative Agarose Gel Electrophoresis. Adkins, N.L., Johnson, C.N. and Georgel, P.T. Journal of Biochemical and Biophysical Methods. Vol. 67. Pp 141-150 (2006).


Reviews

1. "Pulling a Single Chromatin Fiber Reveals the Forces that maintain its Higher-Order Structure" Research by Y. Cui and C. Bustamante, Proc. Natl. Acad. Sci. USA. 2000, 97, 127. Condensation and commentary by P.T. Georgel. Chemtracts. Vol. 13 (13). pp 26-30 (2000) Non-peer reviewed
2. Linker histone function in chromatin: dual mechanism of action. Georgel, P.T. and Hansen, J.C. Biochemistry and Cell Biology. Vol. 79 (3). pp 313-316 (2001), Special Chromatin Issue
3. Chromatin structure of eukaryotic promoters: a changing perspective. Georgel, P.T. Biochemistry and Cell Biology. Vol. 80. pp 295-300 (2002)
4. To the 30-nm Chromatin Fiber and Beyond. Adkins, N.L, Watts, M. and Georgel, P.T. invited review for Biophysica and Biochemica Acta. FASEB meeting Chromatin and Transcription special issue, Vol. 1677. pp 12-23 (2004)
5. Chromatin remodeling complexes: ATP-dependent machines in action. Johnson, C.N., Adkins, N.L. and Georgel, P.T. Biochemistry and Cell Biology. Vol. 83 (4). Pp 405-417 (2005)
6. GAGA protein: a multi-faceted transcription factor. Adkins, N.L., Hagerman, T.A., and Georgel, P.T. Biochemistry and Cell Biology. in press.



 
 
:
Book Chapters

1. Biophysical analysis of specific genomic loci assembled as chromatin in vivo. Philippe T. Georgel and Jeffrey C. Hansen. Methods in Enzymology Vol. 376. pp 17-29 (2004).

Fellowships

1. Fellowship from the "Société de Secours des Amis des Sciences", France (February 1993 to October 1993).
2. Fellowship from the Foundation for Advances and Education in Science (FAES, July 1993 to October 1993).
3. Elected Member of the “Sigma Xi” Research Society in April 2005.


Abstracts

1. Positioning of nucleosomes on a circular template. Georgel, P., van Holde, K.E. FASEB Journal. Vol.6. pp A67 (1992). Biophysical Society and the American Society for Biochemistry and Molecular Biology Meeting (1992), Houston, Texas.
2. Growth control of genes encoding dNTP synthesizing enzymes in yeast and vertebrate cells. Schesser, K. R, Georgel, P. and Merrill, G. F. Recent advances on enzymes in deoxyribonucleotide synthesis (1993), Manoir Saint Sauveur, Saint Sauveur des Monts, Québec, Canada.
3. Toward the structural analysis of in vivo chromatin assembly. Georgel, P.T., Hansen, J.C, Fletcher, T. and Hager, G. Special chromatin issue, Biochemistry and Cell Biology Vol. 79 (3) (2001).
4. Higher order structural changes of in vivo-assembled MMTV LTR promoter chromatin after dexamethasone induction. Philippe T, Georgel, Terrace Fletcher, Gordon Hager and Jeffrey, C. Hansen. Keystone Symposia: Chromatin Structure and Activity (2002) Abstract Book pp 54.
5. Higher order structure of MMTV promoter chromatin before and after dexamethasone-induced transcription in vivo. Philippe T, Georgel, Terrace Fletcher, Gordon Hager and Jeffrey, C. Hansen. Biochemistry and Cell Biology Vol. 80 (3) pp 388 (2002).
6. Role of MeCp2 in the formation of distinct higher order chromatin structures. Philippe T. Georgel, Nina Akimenko, Nicholas L. Adkins, Christopher L. Woodcock, Paul A. Wade and Jeffrey C. Hansen. Biochemistry and Cell Biology Vol. 81 (3) pp 259 (2003).
7. The methyl CpG binding protein, MeCP2, is capable of assembling unique higher order chromatin structures in vitro. Philippe T. Georgel, Rachel A. Horowitz-Scherer, Nick Adkins, Christopher L. Woodcock, Paul A. Wade, and Jeffrey C. Hansen. (Abstract submitted for the FASEB meeting on Chromatin and Transcription,, Snowmass, CO, 7/12/03).
8. 3D conformation of chromatin secondary structures formed by interactions between human MeCP2 and defined chromatin arrays Rachel A. Horowitz-Scherer, Philippe T. Georgel, Jeffrey C. Hansen, Paul A. Wade, Christopher L. Woodcock (abstract submitted to the Rett Syndrome Research Fundation meeting, 6/03).
9. Formation of higher order secondary and tertiary chromatin structures by genomic mouse mammary tumor virus promoters. Georgel, P.T, Fletcher, T., Hager, G. and Hansen, J.C. (Abstract submitted for the FASEB meeting on Chromatin and Transcription, Snowmass, CO, 7/12/03).
10. Can GAGA multimers substitute for nucleosomes? Blaney, S. , Hatcher, E.E., Smith, K.P. and Georgel, P.T (abstract published in Biochemistry and Cell Biology Vol. 82 2004, pp 525).
11. MeCP2 and histone tails. Adkins, N.L, Akimenko, N., Wade, P.A, Hansen, J.C. and Georgel, P.T. (Abstract published in Biochemistry and Cell Biology, Vol. 82 2004, pp 525).
12. Potential links between cell differentiation in salivary glands and chromatin remodeling. Adkins, N.L., Culp, D.J. and Georgel, P.T. (Abstract submitted for the West Coast Chromatin Conference, published in Biochemistry and Cell Biology, Vol 83 (4) 2005 pp 574).
13. DNA-mediated Sir3 silencing. Johnson, C.N., Adkins, N.L., McBryant, S., Hansen, J.C., and Georgel, P.T. (Abstarct submitted for the AACR meeting, Washington D.C., 4/1/06 to 4/5/06)

Recent Invited Seminar Presentations

Title: Formation of higher order secondary and tertiary chromatin structures by genomic mouse mammary tumor virus promoters. FASEB meeting, Snowmass, CO (July 2003).
Title: Chromatin higher-order structure: How does structure affect function? University of Kentucky, Lexington, KY (September 3, 2003).
Title: Influence of Chromatin Compaction on Gene Activation or How Higher-Order Structure Can Regulate Function. University of Virginia, Charlottesville, VA (February 3, 2005).
Title: Influence of Chromatin Compaction on Gene Activation or How Higher-Order Structure Can Regulate Function. University of Miami, Miami, FL (February 23, 2005).
Title: DNA-Mediated Sir3 Silencing. Chromatin Research Group, NIH, Bethesda, MD (April 4, 2006).


Poster presentations

1. Positioning of nucleosomes on a circular template. Georgel, P., van Holde, K.E. FASEB Journal. Vol.6. pp A67 (1992). Biophysical Society and the American Society for Biochemistry and Molecular Biology Meeting (1992), Houston, Texas. Presenter: Philippe Georgel.
2. Putative regulators of apomucin gene expression in rat sublingual glands. Philippe T. Georgel and David J. Culp. Gordon Research Conference (1999), Ventura, California. (No abstract is published: policy of the Gordon Research Conference). Presenter: Philippe Georgel.
3. Higher order structural changes of in vivo-assembled MMTV LTR promoter chromatin after dexamethasone induction. Philippe T, Georgel, Terrace Fletcher, Gordon Hager and Jeffrey, C. Hansen. Keystone Symposia: Chromatin Structure and Activity (Santa Fe, NM, January 2002). Presenter: Philippe Georgel.
4. The methyl CpG binding protein, MeCP2, is capable of assembling unique higher order chromatin structures in vitro. Philippe T. Georgel, Rachel A. Horowitz-Scherer, Nick Adkins, Christopher L. Woodcock, Paul A. Wade, and Jeffrey C. Hansen. (Abstract submitted for the FASEB meeting, Chromatin and Transcription, Snowmass, CO, 7/12/03). Presenter: Nick Adkins.
5. Energy requirement for nucleosome slidding (part 1). Meagan Watts, David Neff, Michael L. Norton, and Philippe T. Georgel (Sigma Xi research day, Huntington, WV, 4/23/04) Presenter: Meagan Watts
6. Tertiary Structure of the GAGA binding sites on the hsp70 promoter. Kristin Smith and Philippe T. Georgel (Winner of the SURF program poster session, Huntington, WV 7/20/03). Presenter: Krisitn Smith.
7. Energy requirement for nucleosome slidding (part 2). Meagan Watts, David Neff, Michael L. Norton, and Philippe T. Georgel (SURF program poster session, Huntington, WV 7/20/03). Presenter: Meagan Watts
8. Effect of GAGA transcription factor binding site mutations on chromatin structure. Elizabeth A. Hatcher, Shawna Blaney, Nick Adkins and Philippe T. Georgel. (Sigma-Xi research day, Huntington, WV 4/23/04). Presenter: Elizabeth A. Hatcher.
9. Contribution of GAGA factor to chromatin structure. Shawna Blaney, Elizabeth Hatcher, Nick Adkins, Kristin Smith, Philippe T. Georgel. (2004 West Virginia Undergraduate Researcher of the Year, Charleston, WV 5/11/04). Presenter: Shawna Blaney
10. Synthesis of DNA template and GAGA factor purification to test GAf effects on Drosophila Heat Shock Protein 70 promoter region. Josh Lewis, Thomas hagerman, Jennifer Leidy, Nicholas Adkins, and Philippe T. Georgel. (SURF program poster session, Huntington, WV, 7/20/04). Presenter: Josh Lewis.
11. Construction of DNA template to test GAGA factor effects on Drosophila heat shock protein 70 promoter region. Joshua Lewis, Thomas Hagerman, Nicholas L. Adkins and Philippe T. Georgel. (Sigma-Xi research day, Huntington, WV 4/22/05). Presenters: Joshua Lewis and Thomas Hagerman.
12. Protein-induced DNA bending. Jennifer M. Leidy, Nicholas, L. Adkins, Philippe T. Georgel (Sigma-Xi research day, Huntington, WV 4/22/05). Presenter: Jennifer Leidy.
13. DNA-mediated Sir3 silencing: formation of Sir3-coated structures in nucleosomes through DNA tracking. Adkins, N.L., Johnson, C.N., NcBryant, S., Woodcock, C.L., Hansen, J.C., and Georgel, P.T. (AACR meeting, Washington DC, 4/5/06). Presenter: Georgel, P.T.

 

Professional/Community Based Service:
 
:
Meeting Organization

1. Co-organizer of the mini-symposium: "DNA and Proteins, dancing partners" at the Carnegie Institute in Washington DC., November 1996.
2. Co-organizer of the symposium: “Frontiers in Life Science: from DNA to Phenotypes” to be held at Marshall University, Huntington, March 29, 2004

Ad hoc reviewer for: Science, Journal of Biological Sciences, Bioch. BioPhys. Res. Communications, Archives of Biochemistry and Biophysics, Journal of Biological Chemistry, European Journal of Cell Biology, Biochimica and Biophysica Acta, Biochemistry and Cell Biology, and FEBS Letters.

Grant reviewer for the NSF, Australian Research Council (nominated Expert of International Standing in 2006), U.S. Defense Department (U.S. Army Medical Research and Materiel Command), North Carolina Biotechnology Center and the Alberta Cancer panel.

Jury member for the West Virginia Science Fair held in Huntington, WV on 3/29/03, 3/27/04, 4/02/05 and 3/25/06.
 

Awards:
 

1. Elected president of the "Maitrise" of Cell Biology and Physiology student association in Poitiers, France, 1987-1988
2. Elected Member of the “Sigma Xi” Research Society in April 2005
3. Nominated Expert of International Standing by the Australian Research Council of International Standing in April 2006
 

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