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Faculty Profile

Name: Pier Paolo Claudio
Title: Associate Professor
Office: Biochemistry and Microbiology & Surgery/ SOM
Phone: 304-696-3516
Email: claudiop@marshall.edu
Expert: Gene Therapy, Stem Cells
 
Achievements

Research Based:
 
Book Chapters:
1. De Luca A., Baldi A., Claudio P.P., Howard C.M., Campisi S., Giordano A., Condorelli G. (1995): The retinoblastoma gene and its role in cancer and differentiation. In Future Trends in Endocrinology. Ares-Serono Symposia Series-Frontiers in Endocrinology 14: 197-206.

2. Howard C.M., Claudio P.P., Carbone M., Giordano A. (1998): SV40 and Human Cancer. in Samuels, S.W. and Upton, A.C. Genes, Cancer and Ethics In the Work Environment. OEM Press, Beverly, MA. 167-174.

3. Claudio P. P., Giordano A. (2000): RB1 and RB2. In Pass H.I., Mitchell J.B., Johnson D.H., Turrisi A.T., Minna J.D. (Ed.) Lung Cancer: Principles and Practice. Lippincot Williams & Wilkins. 7: 133-155

4. Claudio PP, Giordano A. (2003): Preparation of retroviral vectors for cell cycle-targeted gene therapy of lung cancer. In Barbara Driscoll (Ed.) Lung Cancer, volume II, Diagnostic and therapeutic methods and reviews. Methods Mol Med. Humana Press. 75: 591-605.

5. Montella, M., Gallipoli, A., Lorusso, A., Creazzola, S., Claudio, P.P., D’Errico, G. (2003): L’organizzazione della lotta contro i tumori. Capitolo 36. In Mazzeo, F., Forestieri, P. Ed. Piccin Nuova Libraria Padova. Trattato di Chirurgia Oncologica. Vol 1, pag. 36.1-36.23.

6. Claudio, F., Claudio, P.P. (2003): I tumori della lingua. Capitolo 36. In Mazzeo, F., Forestieri, P. Ed. Piccin Nuova Libraria Padova. Trattato di Chirurgia Oncologica. Vol 2, pag. 39.1-39.42.

7. Tiziana Tonini, Pier Paolo Claudio, Antonio Giordano and Gaetano Romano. (2004): in Methods in Molecular Biology. Cell cycle control and dysregulation protocols. Part IV RETROVIRIDAE-BASED VECTORS: PROTOCOLS FOR LENTIVIRAL – AND RETROVIRAL-MEDIATED GENE TRANSFER TO ENGINEER CELL CULTURE SYSTEMS. Transient production of retroviral-and lentiviral-based vectors for the transduction of mammalian cells. Humana Press, Chapter 18.

8. Tiziana Tonini, Pier Paolo Claudio, Antonio Giordano and Gaetano Romano. (2004): in Methods in Molecular Biology. Cell cycle control and dysregulation protocols. Part IV RETROVIRIDAE-BASED VECTORS: PROTOCOLS FOR LENTIVIRAL – AND RETROVIRAL-MEDIATED GENE TRANSFER TO ENGINEER CELL CULTURE SYSTEMS. Determination of functional viral titer by drug-resistance colony assay, expression, expression of green fluorescent protein, and beta-galactosidase staining. Humana Press, Chapter 19.

9. Tiziana Tonini, Pier Paolo Claudio, Antonio Giordano and Gaetano Romano. (2004): in Methods in Molecular Biology. Cell cycle control and dysregulation protocols. Part IV RETROVIRIDAE-BASED VECTORS: PROTOCOLS FOR LENTIVIRAL – AND RETROVIRAL-MEDIATED GENE TRANSFER TO ENGINEER CELL CULTURE SYSTEMS. Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptase. Humana Press. Chapter 20.

10. Pier Paolo Claudio, Antonio Giordano. Angiogenesis and cancer. Practical Medical Oncology . Ed M. Lopez. Second Edition 2005.

11. Molecular Pathology of Gynecological Cancer. Part VII: The multidisciplinary therapeutic approach to gynecological cancer in the new millennium. Chapter 13: The Holistic Approach to Female Cancer Patients. Alessandro Bovicelli, Pier Paolo Claudio and Antonio Giordano. Humana Press.

12. Claudio P.P. and Denning D. (2007): Nasopharyngeal carcinoma. In Cancer Research, an encyclopedic reference book. Springer Ed. 615-618.

13. Paraskevi Vogiatzi and Pier Paolo Claudio. Distinct Roles of the Pocket Proteins in the Control of Cell Cycle. Chapter 19 in: Signal Transduction: Pathways, Mechanisms and Diseases. Springer Ed. (2009, in press).



 
 
Books:
1. Claudio P.P., Savastano G. (1992): I tumori cutanei della faccia. Plastiche ricostruttive dopo exeresi. (Cutaneous tumors of the face. Reconstructive surgery after ablation) Ed. Scientifiche Italiane. Napoli, 1 - 160.

2. Califano L., Claudio P.P. (1995): I tumori della parotide. (Parotid tumors) Ed. Scientifiche Italiane. Napoli, 1-148.
 
 
Publications (peer reviewed):
1. Francesco Claudio, Francesco Cacace, Michele Pizzorusso, Ornella Schiappa, Pier Paolo Claudio, Franco Ionna, Paolo Marcolin, Antonio Amato. (1983): Strategia di trattamento delle aree di drenaggio linfonodale nei tumori del cavo orale. (Strategy of treatment for lymphonodal drenage areas in tumors of the oral cavity) Il medico italiano, 27: 225 - 237.

2. Califano, A. Cortese, P.P. Claudio. (1989): L'alimentazione artificiale in chirurgia maxillo facciale. (Artificial nutrition in maxillo-facial surgery) Boll. Soc. It. Chir. 10, 3: 173 - 177.

3. Claudio, F. Cacace, M. Rotondi, G. Comella, F. Coucourde, P.P. Claudio, A. M. Bevilacqua, S. Bonassi, S. Toma. (1990): La chemioterapia intra-arteriosa nei tumori avanzati dalla testa e collo effettuata mediante una tecnica di trasposizione carotidea. (Intra-artherial chemotherapy in advanced tumors of the head and neck through a carotid surgical transposition technique) Otorinolaringologia 40: 11 - 9.

4. Giardino C., Claudio P.P. (1992): Proposta di una scheda oncologica clinica per i tumori del cavo orale. (Proposal of a new clinical chart for tumors of the oral cavity) Riv. Ital. di Chir. Max. Fac., (3): 39-48.

5. Papa F., Claudio P.P., Letizia N., Maio C., Giardino C. (1992): Su di un caso di cosidetto Fibroma Ossificante. (Consideration on an interesting case of ossifying fibroma) Riv. Ital. di Chir. Max. Fac., (3): 53 - 58.

6. Claudio F., Rotondi M., Bonassi S., Cacace F., Comella G., Coucourde F., Claudio P.P., Bevilacqua A.M., Forma F., Toma S. (1992): Factors affetting response and survival in advance head and neck cancers treated with intrarterial chemotherapy. Regional Cancer Treatment 4: 180 - 187.

7. Claudio F., Rotondi M., Bonassi S., Cacace F., Comella G., Coucourde F., Claudio P.P., Bevilacqua A.M., Spadini N., Toma S. (1992): I fattori prognostici nei tumori avanzati della testa e collo trattati mediante chemioterapia intra-arteriosa. (Prognostic factors in advanced tumors of the head and neck treated with intrarterial chemotherapy) Otorinolaringologia, Vol 42, (5): 273 - 282.

8. Graña X., De Luca A., Sang N., Fu Y., Claudio P.P., Rossenblatt J., Morgan D.O. and Giordano A. (1994): PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc. Natl. Acad. Sci. USA. Vol 91, 3834-3838.

9. Graña X., Claudio P.P., De Luca A. , Sang,N., and Giordano, A. (1994): PISSLRE, a human novel CDC2-related protein kinase. Oncogene 9, 2097-2103.

10. Claudio P.P., Howard C.M., Baldi A., De Luca A., Condorelli G., Sun Y., Colburn N., Calabretta B., Giordano A. (1994): p130/PRb2 has similar yet distinctive growth suppressive properties as retinoblastoma family members, pRb and p107. Cancer Research 54: 5556-5560.

11. Wen S.-C., Ku D.-H., De Luca A., Claudio P.P., Giordano A., and Calabretta B. (1995): ets-2 regulates cdc2 kinase activity in mammalian cells: coordinated expression of cdc2 and cyclin A. Exp. Cell Res. 217, (1): 8-14.

12. Li S., MacLachlan T., De Luca A., Claudio P.P., Condorelli G.L., and Giordano A. (1995): The cdc2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle. Cancer Research 55, 3992-3995.

13. De Luca A., Baldi A., Claudio P.P., Howard C.M., Campisi S., Giordano A., Condorelli G. (1995): The retinoblastoma gene and its role in cancer and differentiation. In Future Trends in Endocrinology. Ares-Serono Symposia Series- Frontiers in Endocrinology 14: 197-206.

14. Baldi A., De Luca A., Claudio P.P., Baldi F., Giordano G.C., Tommasino M., Paggi M.G. and Giordano A. (1995): The Rb2/p130 gene product is a nuclear protein whose phosphorylation is cell cycle regulated. Journal of Cellular Biochemistry 59: 402-408.

15. Claudio P.P., De Luca A., Howard C.M., Baldi A., Firpo E.J., Koff A., Paggi M.G., Giordano A. (1996): Functional analysis of pRb2/p130 interaction with cyclins. Cancer Research 56: 2003-2008.

16. Baldi A., Boccia V., Claudio P.P., De Luca A., Giordano A.(1996): Genomic structure of the human retinoblastoma-related Rb2/p130 gene. Proc. Natl. Acad. Sci. 93: 4629-4632.

17. Esposito V., Baldi A., De Luca A., Paciocco G., Gröger A., Sgaramella G., Claudio P.P., Giordano G.G., Baldi F., Caputi M., Kaiser H., Giordano A. (1997): Role of PCNA in differentiating between malignant mesothelioma and mesothelial hyperplasia: prognostic considerations. Anticancer Research 17: 601-604.

18. Esposito V., Baldi A., De Luca A., Claudio P.P., Signoriello G., Bolognese A., Centonze P., Giordano G.G, Caputi M., Baldi F., Giordano A. (1997): p53 immunostaining in differential diagnosis of pleural mesothelial proliferations. Anticancer Research 17: 733-736.

19. De Luca A., Esposito V., Baldi A., Claudio P.P, Fu Y., Caputi M., Pisano M.M, Baldi F., Giordano A. (1997): The cdc2-related kinase PITALRE phosphorylates pRb exclusively on serine and is widely expressed in human tissues. Journal of Cellular Physiology 172: 265-273.

20. De Luca A., MacLachlan T.K., Bagella L., Dean C., Howard C.M., Claudio P.P., Baldi A., Khalili K., Giordano A. (1997): A unique domain of pRb2/p130 acts as an inhibitor of cdk2 kinase activity. J. Biological Chemisty 272: 20971-20974.

21. Sang N., Claudio P.P, Fu Y., Horikoshi N., Graeven U., Weinmann R., Giordano A. (1997): Transforming Region of 243 R E1A contains two overlapping but distinct Transactivation Domains. DNA and Cell Biology. 16:1321-1333.

22. Papa F., Sagliocco R., Cosimo O., Russo A., Claudio P.P., Errico M., Lavorgna G. (1997): Consideration on a case of carcinoma ex pleomorphic adenoma of the parotid gland. Minerva Stomatol. 46 (11): 615-620.

23. Raschella’, G., Tanno, B., Bonetto, F., Negroni, A., Claudio, P.P., Baldi, A., Amendola, R., Calabretta, B., Giordano, A., Paggi, M. (1998): The RB-related gene Rb2/p130 in neuroblastoma differentiation and in B-myb promoter down-regulation. Cell Death & Diff. 5: 401-407.

24. Leri A., Liu Y., Malhotra A., Li Q., Stiegler P., Claudio P.P., Giordano A., Kajstura J., Hintze H. T., Anversa P. (1998): Pacing-induced heart failure in dogs enhances the expression of p53 and p53-dependent genes in ventricular myocytes. Circulation. 97:194-203.

25. Leri A., Claudio P.P., Li Q., Wang X., Reiss K., Wang S., Malhotra A., Kajstura J., Anversa P. (1998): Stretch mediated release of angiotensin II induces myocytes apoptosis by activating p53 that enhances the local renin-angiotensin system and decrease the Bcl-2-to-Bax protein ratio in the cell. J. Clin. Invest. 101(7):1326-1342.

26. Ravi K.R., Weber E., McMahon M., Williams R. J., Baylin S., Mai A., Harter L. M., Dillehay L.E., Claudio P.P., Giordano A., Nelkin D. B., Mabry M. (1998): Activated Raf-1 causes growth arrest in human small cell lung cancer cells. J. Clin. Invest. 101:153-159.

27. Romano G., Claudio P.P., Kaiser H.E., Giordano A. (1998): Recent advances, prospects and problems in designing new strategies for oligonucleotide and gene delivery in therapy. In Vivo 12: 59-68.

28. Tarro G., Esposito C., Perna M., Claudio P.P., Giordano A. (1998): Immunohistochemical characterization of tumor liberated particles (TLP) expression pattern in lung cancer. Anticancer Res. 18: 2365-2370.

29. Howard C.M., Claudio P.P., Gallia G., Gordon J., Giordano G.G., Khalili K., Giordano A.(1998): Retinoblastoma-related protein pRb2/p130 and suppression of tumor growth in vivo. J.Nat. Cancer Inst. 19: 1451-1460.

30. Mutti L., De Luca A, Claudio P.P., Carbone M., Convertino G., Giordano A. (1998): Simian Virus 40-like DNA sequences and large-T antigen-retinoblastoma family protein pRb2/p130 interaction in human mesothelioma. Dev. Biol.Stand.: 94:47-53.

31. Pacilio C., Florio S., Crispino A., Claudio P.P., Pacilio G., Pagnini G. (1998): Modification of membrane fluidity and depolarization by some anthracyclines in different cell lines. Anticancer Research. 18(6A):4027-4034.

32. Pupa S.M, Howard C. M., Invernizzi A. M., De Vecchi R., Giani C., Claudio P.P., Colnaghi M. I., Giordano A., Ménard S. (1999): Ectopic expression of pRB2/p130 suppresses the tumorigenicity of the erb-2-overexpressing SKOV3 tumor cell line. Oncogene. 18(3): 651-656.

33. Leri A, Liu Y, Claudio PP, Kajstura J, Wang X, Wang S, Kang P, Malhotra A, Anversa P. Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis. (1999) Am J Pathol. Feb;154 (2):567-80.

34. Minimo C., Bibbo M., Claudio P.P., De Luca A., Giordano A. (1999): The role of pRb2/p130 protein in diagnosing lung carcinoma on fine needle aspiration biopsies. Pathol Res and Pract. 195: 67-70.

35. Numata S., Claudio P.P., Giordano A., Croce C.M. (1999): Bdp: a new member of a family of DNA binding proteins, associates with the retinoblastoma gene product.Cancer Research, 59: 3741-3747.

36. Claudio P.P., Fratta L., Stassi G., Howard C.M., Farina F., Numata S., Pacilio C., Davis A., Lavitrano M., Volpe, Wilson J.M., Trimarco B., Giordano A., and Condorelli G. (1999): Adenoviral RB2/p130 gene transfer inhibits smooth muscle cell proliferation and prevents restenosis following angioplasty. Circulation Research, 85:1032-39.

37. Leoncini L., Bellan C., Claudio P.P., Lazzi S., Cevenini G., Megha T., Laurini L., Luzi P., Fraternali Orcioni G., Piccioli M., Pileri S., Giardino C., Tosi G.M., Giordano A. (1999): Retinoblastoma related p107 and pRb2(p130) proteins in malignant lymphomas. Distinct mechanisms of cell growth control. Clinical Cancer Research, 12: 4065-4072.

38. De Falco G., Bagella L., Claudio P.P., De Luca A., Fu Y., Calabretta B., Sala A., Giordano A. (2000): Physical interaction between CDK9 and B-Myb results in suppression of B-myb gene autoregulation. Oncogene , 19: 373-379.

39. Pagnini U., Pacilio C., Florio S., Crispino A., Claudio P.P., Giordano A., Pagnini G. (2000). Medroxyprogesterone acetate increases anthracyclines uptake in chronic lymphatic leukemia cells: role of nitric oxide and lipid peroxidation. Anticancer Research, 20 (1A): 33-42.

40. Claudio P.P., Howard C.M., Fu Y., Califano, L., Mercer E.W., Micheli, P., Caputi, M., Giordano A. (2000): Mutations in the Retinoblastoma-related Gene RB2/p130 in primary nasopharyngeal carcinoma. Cancer Research, 60: 8-12.

41. Claudio P.P., Howard C.M., Pacilio C., Cinti C., Romano G., Minimo C., Maraldi N.M., Minna J.D., Gelbert L., Leoncini, L., Tosi, G.M., Micheli, P., Caputi M., Giordano G.G., and Giordano A. (2000): Mutations in the Retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retroviralmediated gene transfer. Cancer Research, 60: 372-382.

42. Cinti C., Claudio P.P., Howard C.M., Neri L.M., Fu Y., Leoncini, Tosi G.M., Maraldi N.M., Giordano A. (2000) Genetic alterations disrupting the nuclear localization of the retinoblastoma related gene RB2/p130 in human cell lines and primary tumors. Cancer Research, 60: 383-389.

43. Caterina Cinti, Lorenzo Leoncini, Aggrey Nyongo, Filomena Ferrari, Stefano Lazzi, Cristiana Bellan, Alessandra Zamparelli, Pier Paolo Claudio, Nadir Mario Maraldi, Piero Tosi and Antonio Giordano. (2000): Genetic alterations of the retinoblastoma related gene RB2/p130 identify different pathogenetic mechanism in and among Burkitt's lymphoma subtypes. American J. of Pathology, 156 (3): 751-760.

44. Claudio P.P., Caputi M., Giordano A. (2000): The Rb2/p130 gene: the latest weapon in the war against lung cancer? Clin Canc. Research, 6 (3): 754-64.

45. Candace M. Howard, Pier Paolo Claudio, Antonio De Luca, Peter Stiegler, Francesco Paolo Jori, Nabile M. Safdar, Mario Caputi, Kamel Khalili, and Antonio Giordano. (2000): Inducible pRb2/p130 expression and growth suppressive mechanisms: evidence of a pRb2/p130, p27Kip1, and cyclin E negative feedback regulatory loop. Cancer Research, 60: 2737-2744.

46. Perrotti, D., Iervolino, A., Cesi, V., Cirinna, M., Lombardini, S., Grassilli, E., Bonatti, S. Claudio, P.P., Calabretta, B. (2000) BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS (TLS) proteolysis through a protein kinase CbetaII dependent pathway. Mol Cell Biol. 20(16): 6159-69.

47. Claudio, P.P. (2000) Immunohistochemical investigation of new suppressor oncogene p130 in oral squamous cell carcinoma. Oral Oncology, Letter to the Editor 36(5): 497.

48. Cinti C., Claudio P.P., Howard, C.M., Neri L.M., De Luca A., Waterman J.L.F., Azzoni L., Giordano A., Halazonetis T.D., Maraldi N.M. (2000): A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 induces -irradiation resistance affecting pro-apoptotic genes expression. Oncogene, 19 (44): 5098-5106.

49. Pier Paolo Claudio, Peter Stiegler, Candace M. Howard, Cristiana Bellan, Corrado Minimo, Janusz Rak, Al Kovatich, Paola De Fazio, Pietro Micheli, Mario Caputi, Robert Kerbel, Giovan Giacomo Giordano, and Antonio Giordano. (2001): RB2/p130 gene enhanced expression down-regulates Vascular Epithelial Growth Factor expression and inhibits Angiogenesis in vivo. Cancer Research, (62):462-68.

50. Claudio, P. P., Cinti, C., and Giordano, A. Application of the primer in situ DNA synthesis (PRINS) technique to titer recombinant virus and evaluation of the efficiency of viral transduction, Anal Biochem. 291: 96-101., 2001.

51. Galderisi, U., Melone, M. A., Jori, F. P., Piegari, E., Di Bernardo, G., Cipollaro, M., Cascino, A., Peluso, G., Claudio, P. P., and Giordano, A. pRb2/p130 gene overexpression induces astrocyte differentiation, Mol Cell Neurosci. 17: 415-25, 2001.

52. Zini, N., Trimarchi, C., Claudio, P. P., Stiegler, P., Marinelli, F., Maltarello, M. C., La Sala, D., De Falco, G., Russo, G., Ammirati, G., Maraldi, N. M., Giordano, A., and Cinti, C. pRb2/p130 and p107 control cell growth by multiple strategies and in association with different compartments within the nucleus, J Cell Physiol. 189: 34- 44, 2001.

53. Pier Paolo Claudio, Alessandra Zamparelli, Luigi Califano,Aldo Zupi, Cristiana Bellan, Corrado Minimo, Candace M. Howard, Giovanna Carrillo, Pietro Micheli, Caterina Cinti, Lorenzo Leoncini, Costantino Giardino, Antonio Giordano. Expression of Cell-Cycle Regulated Proteins pRB2/p130, p107, E2F4, p27, and of pCNA in Salivary Gland Tumors. Prognostic and diagnostic implications. Rivista Italiana di Chirurgia Maxillo Facciale Vol XII, 1: 37-48, 2001.

54. Francesco Papa, Salvatore Ferrara, Livia Felicetta, Giovanni Lavorgna, Margherita Matarazzo, Stefania Staibano, Sabrina Troisi, and Pier Paolo Claudio. Mandibular metastatic hepatocellular carcinoma: report of a case involving severe and uncontrollable hemorrhage. Anticancer Res. 21: 2121-30., 2001.

55. Pier Paolo Claudio. Asian-American variants of human papillomavirus 16 and risk for cervical cancer: a case control study. J Natl Cancer Inst 2001; 93: 1325-1330. Commentary Basic Sciences, The Women’s Oncology Review, 4: 357-358, 2001.

56. Claudio, P. P., Zamparelli, A., Garcia, F. U., Claudio, L., Ammirati, G., Farina, A., Bovicelli, A., Russo, G., Giordano, G. G., McGinnis, D. E., Giordano, A., and Cardi, G. Expression of Cell-Cycle-regulated Proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in Prostatic Gland Adenocarcinoma, Clin Cancer Res. 8: 1808-15., 2002.

57. Pucci, B., Claudio, P.P., Masciullo, V., Bellincampi, L., Terrioni, A., Khalili, K., Melino, G., Giordano, A. pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 up-regulation and Bcl2 down-regulation. Oncogene 21: 5897-5905, 2002.

58. Condorelli, G.L., Morisco, C., Latronico, M., Claudio, P.P., Dent, P., Tsichlis, P., Condorelli, G., Frati, G., Drusco, A., Croce, C.M., and Napoli C. TNF-α signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-α receptor. FASEB, 16: 1732-37, 2002.

59. Tonini, T., Hillson, C. and Claudio, P.P. Interview with the retinoblastoma family members: do they help each other? J. Cell Physiol. 192, 2: 138-150, 2002.

60. Lazzi, S., Bellan, C., De Falco, G., Cinti, C., Ferrari, F., Nyongo, A., Claudio, P.P., Tosi, G.M., Vatti, R., Gloghini, A., Carbone, A, Giordano, A., Leoncini, L., Tosi, P. Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: Implications for disease pathogenesis. Human Pathol., 33, 7: 723-731, 2002.

61. Claudio, P.P., Tonini, T., Giordano, A. The retinoblastoma family: twins or distant cousins? Genome Biol. 3: 9, REVIEWS3012, 2002.

62. Claudio PP, Giordano A. Preparation of retroviral vectors for cell-cycle-targeted gene therapy of lung cancer. Methods Mol Med 2003: 75: 591-605.

63. Pier Paolo Claudio, Candace, M. Howard A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med 2002; 374:1645-51. Commentary, The Women’s Oncology Review, 3: 113-18-2003.

64. De Falco G., Bellan C., Lazzi S., Claudio P.P., La Sala D., Cinti C., Tosi P., Giordano A., Leoncini L. The interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in the pathogenesis of AIDS-related neoplasms. Oncogene, 22; 6214-19, 2003.

65. Tiziana Tonini, Francesca Rossi, Pier Paolo Claudio. Molecular basis of angiogenesis. Oncogene, 22: 6549-56, 2003.

66. Russo G, Claudio PP, Fu Y, Stiegler P, Yu Z, Macaluso M and Giordano A. RB2/p130 target genes in non-small lung cancer identified by microarray analysis. Oncogene, 22; 6959-69, 2003.

67. Gaetano Romano, Pier Paolo Claudio, Tiziana Tonini, Antonio Giordano. Human immunodeficiency virus type 1 (HIV-1) derived vectors: safety considerations and controversy over therapeutic applications. The European J. of Dermatology, 13 (5): 424-9, 2003.

68. Claudio, P. P., Russo, G., Kumar, C. A., Minimo, C., Farina, A., Tutton, S., Nuzzo, G., Giuliante, F., Angeloni, G., Maria, V., Vecchio, F. M., Campli, C. D., and Giordano, A. pRb2/p130, vascular endothelial growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma: their clinical significance. Clin Cancer Res, 10: 3509-3517, 2004.

69. Tonini, T., Claudio, P. P., Giordano, A., and Romano, G. Transient production of retroviral- and lentiviral-based vectors for the transduction of Mammalian cells. Methods Mol Biol, 285: 141-148, 2004.

70. Tonini, T., Claudio, P. P., Giordano, A., and Romano, G. Determination of Functional Viral Titer by Drug-Resistance Colony Assay, Expression of Green Fluorescent Protein, and beta-Galactoside Staining. Methods Mol Biol, 285: 149-154, 2004.

71. Tonini, T., Claudio, P. P., Giordano, A., and Romano, G. Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptase. Methods Mol Biol, 285: 155-158, 2004.

72. Tonini, T., Bagella, L., D'Andrilli, G., Claudio, P. P., and Giordano, A. Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A. Oncogene, 23: 4930-4937, 2004.

73. Russo G, Giordano A, Claudio P.P. RBL2 (retinoblastoma-like 2). Atlas Genet Cytogenet Oncol Haematol. March 2004. URL : http://www.infobiogen.fr/services/chromcancer/Genes/RBL2ID443.html

74. Vattemi E., Claudio P.P. Gene therapy for lung cancer: practice and promise. Ann Ital Chir. 2004 May-Jun;75(3):279-89.

75. Giuseppe Russo, Alessandra Zamparelli, Candace M. Howard, Corrado Minimo, Cristiana Bellan, Giovanna Carrillo, Luigi Califano, Lorenzo Leoncini, Antonio Giordano, and Pier Paolo Claudio. Expression of Cell-Cycle Regulated Proteins pRB2/p130, p107, E2F4, p27, and of pCNA in Salivary Gland Tumors. Prognostic and diagnostic implications. Clinical Cancer Research, 2005 May 1;11(9):3265-73.

76. Gilberto Sammartino, Mariano Tia, Gaetano Marenzi, A.E. di Lauro, Elio D’Agostino, and Pier Paolo Claudio. Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after extraction of impacted mandibular third molars. JOMS, Jun;63(6):766-70, 2005.

77. Francesco Papa, Antonio Cortese, Maria Cristina Maltarello, Raffaele Sagliocco, Pietro Felice, and Pier Paolo Claudio. Outcome of 50 consecutive sinus lift operations. BJOMS, Aug;43(4):309-13, 2005.

78. Vattemi E., and Claudio P.P. Current status of gene therapy for lung cancer. Drugs of the Future 30: (10), 1017, 2005.

79. Giacinti L., Claudio P.P., Giordano A. Epigenetic Information and Estrogen Receptor Alfa Expression in Breast Cancer. The Oncologist, 2006 Jan;11(1):1-8.

80. Merola E. Claudio PP, Giordano A. p53 and the malignant progression of Barrett's esophagus. J Cell Physiol. Mar; 206(3):574-7, 2006.

81. Francesca Sanseverino, Rosa Santopietro, Michela Torricelli, Giuseppina D’Andrilli, Gabriele Cevenini, Alessandro Bovicelli, Lorenzo Leoncini, Giovanni Scambia, Felice Petraglia, Antonio Giordano and Pier Paolo ClaudiopRb2/p130 and VEGF expressions in endometrial carcinoma in relation to angiogenesis and tumor histopathologic grade. Cancer Biol Ther. 2006 Jan 22;5(1).

82. Elettra Merola, Eliseo Mattioli, Corrado Minimo, Weineng Zuo, Carla Rabitti, Michele Cicala, Renato Caviglia, Lucio Pollice, Antonio Giordano and Pier Paolo Claudio. Immunohistochemical evaluation of pRb2/p130, VEGF, EZH2, p53, p16, p21waf-1, p27, and PCNA in Barrett’s Esophagus. Journal Cell Physiology, 207(2): 512-9, 2006.

83. Vogiatzi, P, De Falco G., Claudio PP, Giordano A. How Does the Human RUNX3 Gene Induce Apoptosis in Gastric Cancer? Latest Data, Reflections and Reactions. Cancer Biol Ther. (4):371-374, 2006.

84. Abbadessa G., Santoro A., and Claudio P.P. Meeting Report: 42nd Annual Meeting of the American Society of Clinical Oncology (ASCO) June 2-6, 2006, Atlanta, GA. Drugs of the Future 31:(7), 2006.

85. Pier Paolo Claudio, Chiara Mariano, Sujatha Radhakrishnan, Kamel Khalili, Mahmut Safak, Antonio Giordano, Shohreh Amini, and Bassel E Sawaya. Phosphorylation of p53 by cdk9 prevents HIV-1 gene transcription and viral replication. Journal Cell Physiology 208(3): 602-612, 2006.

86. Genovese C., Trani D., Caputi M., Claudio, P.P. Cell cycle control and beyond: emerging roles for the retinoblastoma gene family. Oncogene. 2006 Aug 28;25(38):5201-9.

87. Vogiatzi, P., Abbadessa, G., Cassone, M., Claudio, P.P. The limitless role of p53 in cell cycle machinery: good news or bad news? Cancer Biol Ther. 2006 Sep; 5(9):1090-3.

88. Vattemi M, and Claudio PP. Adenoviral gene therapy in head and neck cancer. Drug News Perspect. 2006 Jul-Aug;19(6):329-37.

89. Howard, C.M., Forsberg F., Liu, J.B., Merton D.A., Minimo C., Pier Paolo Claudio Ultrasound guided site specific gene delivery system using adenoviral vectors and commercial ultrasound contrast agents. Journal Cell Physiology 2006 Nov; 209 (2):413-21.

90. Paraskevi Vogiatzi, Marco Cassone, and Pier Paolo Claudio. On the road to personalizing gene therapy in gastric cancer: proposals for transforming dreams into reality. Drug News Perspect. 2006 Nov;19(9):533-40.

91. Eliseo Mattioli, Paraskevi Vogiatzi, Ang Sun, Giovanni Abbadessa, Giulia Angeloni, Domenico D’Ugo, Daniela Trani, John P. Gaughan, Fabio Maria Vecchio, Gabriele Cevenini, Roberto Persiani, Antonio Giordano, and Pier Paolo Claudio Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16 INK4A, p27KIP1, p21WAF1, Ki-67 expression patterns in gastric cancer. J Cell Physiol. 2007 Jan; 210(1):183-91.

92. Bagella, Tiziana Tonini, Giuliano Cottone, Pier Paolo Claudio, Marco G. Paggi, Antonio De Luca, Antonio Giordano. A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity and cell cycle arrest. Oncogene, 2007 Mar 22;26(13):1829-39

93. De Falco, G., Leucci, E., Lenze, D., Piccaluga, PP, Claudio, PP, Onnis, A., Cerino, G., Nyagol, J., Mwanda, W., Bellan, C., Hummel, M., Pileri, S., Tosi, P., Stein, H., Giordano, A., Leoncini, L. Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt's lymphoma cell lines and primary tumors. Blood. 2007 Aug 15;110(4):1301-7.

94. Giovanni Abbadessa, Paraskevi Vogiatzi, Lorenza Rimassa and Pier Paolo Claudio. Antiangiogenic drugs currently used for colorectal cancer: what other pathways can we target to prolong responses? Drug News and Perspectives, June 2007, 20 (5), 1-7.

95. Antonio Graziano, Vincenzo Desiderio, and Pier Paolo Claudio. Stem cells in tissue engineering for therapeutic use, a promising tool or an approachable reality? Drugs Future 31(12): 1117, 2006.

96. Candace M. Howard and Pier Paolo Claudio Meeting report of the 2006 Radiological Society of North America (RSNA). Molecular imaging: Novel techniques that not only visualize cellular changes driving disease processes before they become apparent anatomically, but also useful therapeutic tools for multiple diseases? Drugs of the Future, 2007.

97. Emanuela Vattemi and Pier Paolo Claudio Advances and Perspectives of Gene- Based therapy for Brest Cancer. Drugs Fut 32(6): 507, 2007.

98. Emanuela Vattemi and Pier Paolo Claudio Tumor Suppresor Genes as Cancer Therapeutics Drugs News Perspectives Oct;20(8):511-20, 2007.

99. Paraskevi Vogiatzi, Pierpaolo Aimola, Scarano M. Irene and Pier Paolo Claudio. Epigenome: from the control of cell growth to cancer. Drug News Perspectives Dec;20(10):627-33, 2007.

100. Gilberto Sammartino, Gaetano Marenzi, Candace Howard, Oreste Trosino, Corrado Minimo, Luigi Califano, and Pier Paolo Claudio. Chondrosarcoma of the jaw: an anterior mandibular localization. A case report with a four-year follow-up. Journal of Maxillofacial Surgery 2008 Nov;66(11):2349-55.

101. S. E. Kelly, Di Benedetto A., Valluri, J.V., Claudio, P.P. Selection and Proliferation of Stem Cells. Gravitational and Space Biology, 2008.

102. Manuela Vattemi and Pier Paolo Claudio. The feasibility of Gene Therapy in the Treatment of Head and Neck Cancer. Head and Neck Oncology. Invited Review Article. Head Neck Oncol. 2009 Jan 12;1(1):3.

103. Manuela Vattemi and Pier Paolo Claudio. CONTUSUGENE LADENOVEC. Monograph, Drugs of the Future 2009, 34(3):1-6.

104. Adelaide Greco, Altomare DiBenedetto, Candace Howard, Sarah Kelly, Yulia Dementieva, Michele Miranda, Arturo Brunetti, Marco Salvatore, Luigi Claudio, Devanand Sarkar, Paul B. Fisher, and Pier Paolo Claudio. Eradication of therapy-resistant human prostate tumors using an ultrasound guided site-specific Mda7/IL-24 cancer terminator virus. Molecular Therapy (in press, 2009).

105. Gilberto Sammartino, Mariano Tia, Gaetano Marenzi, Eva Gentile, and Pier Paolo Claudio. Could PRP and resorbable membrane be considered an effective solution in the prevention of periodontal defects following deep impacted lower third molar extraction? Journal of Maxillofacial Surgery. (in press, 2009).

106. Paraskevi Vogiatzi, Marco Cassone, Luigi Claudio, and Pier Paolo Claudio Targeted Therapy for Hormone-Refractory Prostate Cancer: Looking Through New Lenses. Drugs News and Perspectives (in press, 2009).

107. Vincenzo Desiderio, Antonio Graziano, Pierpaolo Aimola and Pier Paolo Claudio. Stem cells in cancer therapy: from their role into pathogenesis to their use as therapeutic agents Drugs News and Perspectives (in press, 2009).
 

Awards:
 
Fellowships
1989-1994 Fellowship awarded for training in Maxillo-Facial Surgery at the
Department of Maxillo-Facial Surgery, University of Naples “Federico II,” Italy.

1994-1995 Fellowship from “Lega Nazionale Lotta contro i Tumori” of the
National Institute of Tumor “Fondazione Senatore Pascale,” Naples, Italy.

1995-1997 Fellowship from the American-Italian Cancer Foundation, New York, USA.

1999-2001 Fellowship from the “Associazione Leonardo di Capua”, Napoli, Italy.
 
 
Professional Awards
1987 II Edition of the national award for young researchers “A. Schweitzer”, Italy.

1989 M.D. Degree, Summa cum laude.

1994 Residency program in Maxillo-Facial Surgery, Summa cum laude.

1999 Lions Club Napoli-Mergellina Award for outstanding achievements in cancer research.

2002 Who’s Who in Science and Engineering, 2002 edition.

2003 Who’s Who in Science and Engineering, 2003 edition

2003 2000 Outstanding Scientists of the 21st Century.

2004 Who’s Who in Science and Engineering, 2004 edition

2004 Research Board of Advisors, Who’s is Who.

2004 Rotary Club – Napoli Award for outstanding achievements in gene therapy

2007 International Award “Sebetia-Ter” for Biomedical Sciences

2008 Lion’s Club Fondi Award for Stem Cell Research
 
 
Research Grants
WW Smith Charity Foundation. # C0305
Pier Paolo Claudio (PI): Ultrasound enhancement of viral-mediated gene transfer following systemic administration. $ 120,000 (Expired 2006)

NIH R01 CA60999: Rb2/p130 from the mechanism to gene therapy.
Pier Paolo Claudio (CoPI) $ 1,250,000 (Expired 2009)

NIH P01 NS36466-08: Project #2 Tumor suppressor Rb family/pRb2 in medulloblastoma.
Pier Paolo Claudio (CoPI) $ 750,000 Project#2 (Expired 2009)

CDDC grant: Microgravity sensitization to chemotherapy of multi-drug resistant cancer cells
Pier Paolo Claudio (PI) $ 20,000/year (Expired 2008)

NIH R21 CA131395 Ultrasound guided site-specific gene delivery in prostate cancer
Pier Paolo Claudio (PI) $ 385,000 - Active 2009-2011

NIH R03: Image guided enhancement of mda-7 gene therapy in pancreas adenocarcinoma
Pier Paolo Claudio (PI) $100,000 - Active 2009-2011
 

Other Achievements:
 
Journal Editor:
2001- The women’s oncology review (Assistant and contributing Editor)

2004- Regional Editor of the Journal of Experimental & Clinical Cancer Research (Editor-USA)

2005- International Journal of Biomedical Science (Molecular Biology Section)

2005- Drugs News and Perspectives (Editor-USA)

2005- Drugs of Today (Editor USA)

2005- Drugs of the Future (Editor USA).

2006- Journal Experimental & Clinical Cancer Research (Editor-USA)

2008 Current Signal Transduction Therapy (Editor-USA)
 
 
University Services:
2006-present Member of Marshall University Library Committee

2007-present Member of the Marshall University Institutional Biosafety Committee (IBC)

2008-present Member of the Marshall University Faculty Senate
 

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