2014 Participants
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NAME: Erin Fankhanel

PROJECT TITLE: Nano-therapy for sepsis induced kidney injury

Despite ongoing efforts for effective treatments, sepsis remains a leading cause of death and causing problems for hospitals, both in health and financially. Cerium oxide has recently been shown to reduce the effects of sepsis, particularly by its antioxidant properties. It is thought that the antioxidant properties are beneficial in reducing the organ dysfunction and damage occurring as a result of sepsis. Kidney injury will be the focus of this research in particular, to determine if cerium oxide is effective in preventing, reducing, or reversing the sepsis-induced kidney injury. To determine the efficacy of cerium oxide as a treatment for kidney injury, male Sprague Dawley rats will be randomly placed in one of four groups: control, cerium oxide only, sepsis, and sepsis plus cerium oxide treatment. Data will be collected through histological and biochemical methods after kidney tissue is collected and stored at animal sacrifice, as well as data for the physical assessment of the kidney function and morphology. Taken together, these results will be used to provide insight into the mechanism and efficacy of using cerium oxide nanoparticles to treat kidney injury. The results of this study may possibly be helpful in leading to new treatments of sepsis and the organ dysfunction linked to the condition. Specific to this study, the results can lead to increased knowledge about kidney damage due to sepsis and the effects of cerium oxide exposure on sepsis-induced injured kidneys.