NAME: Hari Vishal Lakhani
Obesity and vascular dysfunction are major contributors to cardiovascular disease (CVD). CVD remains a major cause of morbidity and mortality in the United States and places a major economic burden upon Appalachian society. Oxidative stress-mediated endothelial cell injury and an increase in the number of circulating endothelial cells (CEC) are seen in many cardiovascular diseases including acute myocardial infarction and coronary artery disease. Endothelial dysfunction is thought to result, in part, from the injurious action of established vascular disease risk factors such as diabetes, obesity and hypertension. Ample evidence indicates that high levels of inflammatory markers, CECs and 20-HETE (a powerful vasoconstrictor) are responsible for superoxide generation and endothelial cell dysfunction. Adiponectin has emerged as important modulator of vascular function acting as vasodilator and anti-inflammatory factor. We have previously reported the presence of a marked increase in CEC in both humans and mice with hypertension, obesity and diabetes.
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