2007 Participants
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Christina Newsome
Huntington, WV
Working with Dr. Leslie Frost

Visit Christina's webpage here: http://mupfc.marshall.edu/~newsome34

The C-peptide of insulin was thought to be biologically inactive, but recent studies have shown that the C-peptide causes multiple molecular and physiological effects.  There is evidence that the C-peptide binds to a cell surface receptor, probably a G-protein coupled receptor, and that the COOH-terminal pentapeptide is essential for binding and constitutes an active site.  For a further understanding of the detailed nature of the physiological effects of C-peptide, the receptor structure will have to be determined.  We hope to identify the cellular receptor for the insulin C-peptide