A team of researchers led by a Marshall University faculty member has found that
a gene therapy “cocktail” may hold the key to treating feline fibrosarcoma—an
aggressive type of cancer that affects thousands of cats in the U.S. each year.
Current therapies for the disease are often ineffective for long-term tumor
The research was conducted by Dr. Pier Paolo Claudio, associate professor in the Biomedical Sciences Graduate Program and the Departments of Biochemistry and Microbiology and Surgery at the Joan C. Edwards School of Medicine, and colleagues from the McKown Translational Research Institute at the school of medicine, the university’s Department of Biology, the Martin Veterinary Clinic in Ashland, Ky., and the University of L’Aquila in Italy.
The study at Marshall focused on the rare non-vaccination site fibrosarcoma, which have been found to be associated with genetic alterations. It seemed a natural fit for Claudio, whose research focuses on understanding the molecular mechanisms governing the growth of cancers to help develop new strategies for treatment.
The research was published last week in the journal PLoS ONE. The full article, “Targeting a newly established spontaneous feline fibrosarcoma cell line by gene transfer,” is available online at http://dx.plos.org/10.1371/journal.pone.0037743.
Claudio was in Italy last week where he presented three invited lectures about his research. He spoke at the National Cancer Institute and the CEINGE Institute in Naples, and at the meeting “Fragment of history: Seminar on the oral medicine of the past and of the future” in Sorrento.
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