Department: Pharmacology, Physiology & Toxicology
Research Cluster: Neuroscience and Developmental Biology
- Impact of REM sleep loss on hippocampal memory functions.The hippocampus is one of the major brain structures required for memory formation. Memory formation occurs through enhancement (potentiation) of synaptic function, and memory formation is impaired by sleep disruption. We are examining how deprivation of the Rapid Eye Movement (REM) portion of sleep affects hippocampal synaptic functions related to memory. We are also examining hippocampal-dependent learning using a spatial memory task (Morris water maze). One area of focus is the potential role of hormones as mediators for the effects of REM sleep loss on hippocampal function.
- Models of signaling mechanisms in LTP. In the hippocampus, brief periods of high activity at excitatory synapses cause long lasting potentiation (LTP) of synaptic transmission. LTP is widely used as a cellular model for the synaptic changes which occurs during memory formation. In this project we combined experimental (my laboratory) and computation (Bill Holmes, Ohio University) approaches to model processes occurring at the cell, synapse and molecular levels during LTP.
Spitzer N, Sammons GS, Butts HM, Grover LM, Price EM. Multipotent progenitor cells derived from adult peripheral blood of swine have high neurogenic potential in vitro. J Cell Physiol. 2011 Dec;226(12):3156-68.
Patterson SL, Grover LM, Schwartzkroin PA, Bothwell M. Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9: 1081-1088, 1992.