Translational research aims to transfer discoveries from the laboratory to the bedside quickly
Wednesday, Feb. 27, 2013
HUNTINGTON, W.Va. – Marshall University Joan C. Edwards School of Medicine officials today announced $150,000 in funding for six research grants associated with the school’s translational medicine research program.
The Marshall Health Translational Pilot Grant program, created in 2012, encourages collaborative research between basic scientists and clinical physicians in an effort to speed up the process of laboratory discovery to clinical application for patients. The grants are funded by Marshall Health.
“We are very pleased that Marshall Health has created this grant program to stimulate research efforts,” said Richard M. Niles, Ph.D., senior associate dean for Biomedical Sciences at the School of Medicine. “Moving Marshall to the next level of medical research takes vision, commitment and of course, funding. This grant allows 12 researchers, as well as medical residents and students, the opportunity to explore very diverse areas.”
Marshall Health is the faculty practice plan for the Joan C. Edwards School of Medicine and supports the clinical, educational, research and services missions of the school. Beth Hammers, executive director of the organization, says the pilot grant program provides one year of support at $25,000 for each grantee, with additional funding based on progress of the research.
“Medical research is essential to the development of new medical treatments and cures for patients,” Hammers said. “We are thrilled to help stimulate a robust, viable grant program which pairs basic scientists from Marshall University with School of Medicine physicians to work on projects which will lead to the betterment of our community.”
The investigators and their projects are listed below:
Dr. Pier Paolo Claudio, Department of Biochemistry and Microbiology, and Dr. Anthony Alberico, Department of Neuroscience – “Chemotherapy resistance and sensitivity testing in tumors of the central nervous system”
Dr. Elaine Hardman, Department of Biochemistry and Microbiology, and Dr. James Jensen, Department of Surgery – “Feasibility and Safety of Nutritional Supplementation with Omega-3 Fatty Acids to Reduce Prostate Specific Antigen Rise in Men with Biochemical Failure after Prostatectomy or External-Beam Radiotherapy”
Dr. Nalini Santanam, Department of Pharmacology, Physiology and Toxicology, and Dr. Paulette Wehner, Department of Cardiology – “Perivascular Fat Relation to Hypertension—Appalachian Heart Study”
Dr. Nalini Santanam, Department of Pharmacology, Physiology and Toxicology, and Dr. Abid Yaqub, Department of Medicine, Endocrinology Section – “Impact of Technology-based Behavioral Intervention on Molecular and Clinical Parameters in Patients with Type 2 Diabetes”
Dr. Monica Valentovic, Department of Pharmacology, Physiology and Toxicology, and Dr. Brenda Dawley, Department of Obstetrics and Gynecology – “Prenatal Exposure to Heavy Metals and Polycyclic Aromatic Hydrocarbons (PAH) Alter Umbilical Cord Blood Levels of Thyroid Hormone and Vitamin D”
Dr. Hongwei Yu, Department of Biochemistry and Microbiology, and Dr. Yoram Elitser, Department of Pediatrics – “Investigate the distribution of segmented filamentous bacteria (SFB) in American children and the presence of SFB with childhood diseases”
Other current translational research under way at the Marshall University Joan C. Edwards School of Medicine includes a partnership with the University of Kentucky (UK) as part of the National Institutes of Health’s Clinical and Translational Science Awards program, which also is aimed at speeding the time for laboratory discoveries to benefit patients.
In 2011, UK and its partners received $20 million for the program to support research at UK’s Center for Clinical and Translational Science, making Marshall part of a select national biomedical research network.
Contact: Ginny Painter, Communications Director, Marshall University Research Corporation, 304.746.1964, or Leah C. Payne, Director of Public Affairs, Schools of Medicine and Pharmacy, 304-691-1713

Dr. Santanam will be presenting her research internationally at the International Society of Antioxidants in Nutrition and Health’s (ISANH) 2nd World Congress on Fertility and Antioxidants Therapy, December 6 – 7, 2012 in Paris, France.
the sexes; she states that with this study, they are “trying to identify biomarkers unique to this particular fat so that we can use it in the future to diagnose or in the treatment of coronary artery disease.” Additionally, the biomarkers found in the adipose tissue have been correlated to patients with hypertension. This study is part of the West Virginia Appalachian Heart Study; therefore most of the individuals included in this study are Appalachians. Dr. Santanam would like to acknowledge: Dr. Christopher Adams, Dr. Nepal Chowdhury, Dr. Todd Gress, and Dr. Paulette Wehner.
Mardochee Isme, a senior student at Bluefield State College in Bluefield, West Virginia, and a 2012 participant in West Virginia IDeA Network of Biomedical Research Excellence’s (WV-INBRE) Summer Research Program at Marshall University, is the winner of a Student Travel Award from the Annual Biomedical Research Conference for Minority Students (ABRCMS). Isme will attend the 2012 ABRCMS conference located in San Jose, CA, November 7 – 10, 2012 to present her research. The travel award is worth $1,500 and can go toward any travel-related expenses to the conference and/or conference registration fees.
Omni Shoreham Hotel and was attended by six faculty members from the Joan C. Edwards School of Medicine, Marshall University in the West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) program, three from West Virginia University and one each from Bluefield State College, Concord College, West Virginia State University, West Virginia Wesleyan College and the University of Charleston. Several of the Marshall University faculty presented research during the meeting including Drs. Monica Valentovic, Nalini Santanam
and Travis Salisbury from the Department of Pharmacology, Physiology and Toxicology and Dr. Donald Primerano from the Department of Biochemistry and Microbiology. Also presenting research was Andre Benja Lamyaithong, an undergraduate student at Wheeling Jesuit University, who has been conducting research on antidotes for acetaminophen overdose with Dr. Valentovic for two summers as part of the West Virginia INBRE summer research program. Other JCE School of Medicine faculty members attending the meeting were: Dr. Jim Denvir, Department of Biochemistry and Microbiology, who co-authored the work with Dr. Primerano; and Dr. Gary Rankin, Department of Pharmacology, Physiology and Toxicology, who is a member of the Executive Planning Committee for the NISBRE meeting.
Dr.Valentovic’s research on how a component of grapes and red wine (resveratrol) can reduce damage to the kidney caused by a commonly used drug (cisplatin) to treat cancer was presented in a regular research session and highlighted in a special session on clinical and translational research. In addition, Dr. Primerano’s research into the genetics of families with high blood cholesterol was highlighted in a special session on cardiovascular disease.
Currently, 23 states and Puerto Rico are eligible to compete for COBRE or INBRE grants. Marshall University was awarded an INBRE grant as the lead institution in 2004 with West Virginia University serving as a partner lead institution. Dr. Gary Rankin, Professor and Chair of the Department of Pharmacology, Physiology and Toxicology at Marshall University is the Principal Investigator for the WV-INBRE program.
Dr. Christopher Adams, first year Cardiology fellow, Marshall University, School of Medicine, Huntington WV, presented and won the top prize for the best poster presentation in both regional and national conferences held by the American College of Cardiology for his work on “Perivascular Fat Biomarkers and Corresponding Echocardiographic Evidence: WV‐Appalachian Heart Study”.
On March 23, 2012, the Marshall University Cell Differentiation and Development Center (CDDC) held its second annual regional research symposium. The CDDC symposium focused on bioinformatics and the ways in which it is used to study the molecular interactions involved in the regulation of gene expression.


Rebecca Furby, a participant of the 2011 SRIMS program at Marshall University, has won an award from the Federation of American Societies for Experimental Biology, or FASEB, to present at a national conference. The FASEB Minority Access to Research Careers (MARC) program’s mission statement is to “achieve greater participation in the biomedical and behavioral research enterprise of this country by individuals from underrepresented minority groups.” Underrepresented minority undergraduate and graduate students, post-baccalaureates, postdoctorates, junior faculty, and faculty scientists in the behavioral and biomedical sciences are eligible to apply for the award.