{"id":1300,"date":"2011-04-28T12:02:52","date_gmt":"2011-04-28T16:02:52","guid":{"rendered":"http:\/\/www.marshall.edu\/forensics\/?p=1300"},"modified":"2015-12-08T09:50:28","modified_gmt":"2015-12-08T14:50:28","slug":"lagrone-research-poster","status":"publish","type":"post","link":"https:\/\/www.marshall.edu\/forensics\/news\/lagrone-research-poster","title":{"rendered":"Research Day 2011 – Erin LaGrone – Trifluoroacetyl Derivatization of Amphetamine, Methamphetamine, MDMA and Other Controlled Substances with Similar Mass Spectra"},"content":{"rendered":"

Trifluoroacetyl Derivatization of Amphetamine, Methamphetamine, MDMA and Other Controlled Substances with Similar Mass Spectra<\/strong><\/p>\n

Biography:<\/strong><\/p>\n

Erin Elizabeth LaGrone is from Katy, Texas, and she received her bachelor\u2019s degree in chemical engineering from Lamar University in Beaumont, Texas.\u00a0 She will graduate this May with her master\u2019s degree in forensic science from Marshall University with emphases in forensic chemistry and crime scene investigation.\u00a0 This past summer she interned with the forensic chemistry division of the Austin Police Department in Austin, Texas, where she conducted research in the derivatization of controlled substances.<\/p>\n

Abstract:<\/strong><\/p>\n

\u00a0For the identification of a controlled substance, mass spectrometry is the most commonly used method. \u00a0However, there are some cases where the controlled substance shares a similar mass spectrum with a drug of a lower scheduling or a compound that is not even considered to be a controlled substance, such as methamphetamine and phentermine.\u00a0 Here, it is proposed that the derivatization of these compounds will create mass spectra that are sufficiently different enough to make a positive identification.\u00a0 Controlled substance standards were derivatized with trifluoroacetic anhydride and analyzed with a GC-MS, resulting in unique, identifiable spectra for each standard.<\/p>\n

Poster:<\/strong><\/p>\n

\u00a0\"Trifluoroacetyl<\/a><\/strong><\/p>\n

References:<\/strong><\/p>\n

    \n
  1. Zaitsu, K., Katagi, M., Kamata, H. T., Miki, A., Tsuchihashi, H., \u201c Discrimination and identification of regioisomeric \u03b2-keto analogues of 3,4-methylenedioxyamphetamines by gas chromatography-mass spectrometry,\u201d Forensic Toxicology, Vol. 26, 2008, pp. 45-51<\/li>\n
  2. \u00a0\u201cSWGDrug Recommendations,\u201d Scientific Working Group for the Analysis of Seized Drugs, 5th Ed., 29 January 2010, pp. 14-16<\/li>\n
  3. Frison, G., Tedeschi, L., Favretto, D., Reheman, A., Ferrara, S. D., \u201cGas chromatography\/mass spectrometry determination of amphetamine-related drugs and ephedrines in plasma, urine and hair samples after derivatization with 2,2,2-trichloroethyl chloroformate,\u201d Rapid Communications in Mass Spectrometry, Vol. 19, 2005, pp. 919-927<\/li>\n
  4. \u00a0\u201cThermo Scientific Pierce Reagents, Solvents and Accessories,\u201d Thermo Scientific, 2008, pp. 1,2, 4, 13, 16<\/li>\n
  5. Gan, B. K., Baugh, D., Liu, R. H., Walia, A. S., \u201cSimultaneous Analysis of Amphetamine, Methamphetamine, and 3,4-Methylenedioxymethamphetamine (MDMA) in Urine Samples by Solid-Phase Extraction, Derivatization, and Gas Chromatography\/Mass Spectrometry,\u201d Journal of Forensic Sciences, Vol. 36, 1991, pp. 1331-1341<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Trifluoroacetyl Derivatization of Amphetamine, Methamphetamine, MDMA and Other Controlled Substances with Similar Mass Spectra Biography: Erin Elizabeth LaGrone is from Katy, Texas, and she received her bachelor\u2019s degree in chemical engineering from Lamar University in Beaumont, Texas.\u00a0 She will graduate this May with her master\u2019s degree in forensic science from Marshall University with emphases in<\/p>\n","protected":false},"author":120,"featured_media":1302,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4,5],"tags":[150,113,120],"class_list":["post-1300","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-research","tag-research","tag-research-day-2011","tag-students"],"acf":[],"fimg_url":"https:\/\/www.marshall.edu\/forensics\/files\/2011\/04\/Lagrone.jpg","_links":{"self":[{"href":"https:\/\/www.marshall.edu\/forensics\/wp-json\/wp\/v2\/posts\/1300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.marshall.edu\/forensics\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.marshall.edu\/forensics\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.marshall.edu\/forensics\/wp-json\/wp\/v2\/users\/120"}],"replies":[{"embeddable":true,"href":"https:\/\/www.marshall.edu\/forensics\/wp-json\/wp\/v2\/comments?post=1300"}],"version-history":[{"count":0,"href":"https:\/\/www.marshall.edu\/forensics\/wp-json\/wp\/v2\/posts\/1300\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.marshall.edu\/forensics\/wp-json\/wp\/v2\/media\/1302"}],"wp:attachment":[{"href":"https:\/\/www.marshall.edu\/forensics\/wp-json\/wp\/v2\/media?parent=1300"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.marshall.edu\/forensics\/wp-json\/wp\/v2\/categories?post=1300"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.marshall.edu\/forensics\/wp-json\/wp\/v2\/tags?post=1300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}