{"id":26989,"date":"2024-07-17T15:47:10","date_gmt":"2024-07-17T19:47:10","guid":{"rendered":"https:\/\/www.marshall.edu\/news\/?p=26989"},"modified":"2024-07-17T15:47:10","modified_gmt":"2024-07-17T19:47:10","slug":"marshall-university-researcher-awarded-american-heart-association-grant-to-explore-novel-treatment-for-hypertension-related-ischemic-stroke","status":"publish","type":"post","link":"https:\/\/www.marshall.edu\/news\/2024\/07\/marshall-university-researcher-awarded-american-heart-association-grant-to-explore-novel-treatment-for-hypertension-related-ischemic-stroke\/","title":{"rendered":"Marshall University researcher awarded American Heart Association grant to explore novel treatment for hypertension-related ischemic stroke"},"content":{"rendered":"
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Through its Transformational Project Award, the American Heart Association supports \u201chighly innovative, high-impact projects that build on work in progress that could ultimately lead to critical discoveries or major advancements that will accelerate the field of cardiovascular and\/or cerebrovascular research.\u201d<\/span>\u00a0<\/em><\/div>\n
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HUNTINGTON, W.Va.<\/strong> – <\/span>Jinju Wang, Ph.D., <\/span>assistant professor of biomedical sciences at the Marshall University Joan C. Edwards School of Medicine, <\/span>has received<\/span> a <\/span>T<\/span>ransformational <\/span>P<\/span>roject <\/span>Award<\/span> from th<\/span>e American Heart Association <\/span>to evaluate<\/span> the potential effects of angiotensin-converting enzyme 2 (ACE2) <\/span>modified<\/span> exosomes in hypertension-related ischemic stroke.<\/span><\/span><\/p>\n<\/div>\n

ACE2 is a protein that regulates blood pressure by breaking down angiotensin II, a peptide that narrows blood vessels.<\/span> By delivering ACE2, these exosomes can help reduce blood pressure by converting angiotensin II into its less harmful form.<\/span> Wang\u2019s<\/span> new three-year $300,000 grant (24TPA1291189) will <\/span>utilize<\/span> a transgenic mouse model with hypertension to test the effects of these modified exosomes<\/span>.<\/span><\/span><\/p>\n

“The rising incidence of stroke among the aging and hypertensive population underscores the pressing need for innovative ischemic stroke therapies, especially for elderly individuals,\u201d said Wang, principal investigator on the study. \u201cThis study introduces ACE2-modified exosomes as a promising novel therapeutic avenue for ischemic stroke in the context of aging and hypertension. It will significantly contribute to expanding the practical application of ACE2-modified exosomes in the context of cerebrovascular disorders, serving as a proof-of-concept for the versatile delivery of biomedical molecules through exosomes.\u201d<\/span>\u00a0<\/span><\/p>\n

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The anti-inflammatory and protective effects of ACE2 could mitigate the damage caused by stroke, particularly in hypertensive patients<\/span>.<\/span> T<\/span>he successful completion of this <\/span>could lead to <\/span>novel treatment<\/span>s<\/span> aimed<\/span> at<\/span> lessen<\/span>ing<\/span> the severity of ischemic stroke in elderly patients with hypertension.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div>\n

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In addition to Wang, the study team includes<\/span> Marshall biomedical sciences faculty members <\/span>Ji Bihl, Ph.D., <\/span>co-investigator on the study, and consultants <\/span>Alejandro Q. Nato<\/span> Jr.<\/span>, Ph.D., <\/span>Lawrence Grover, Ph.D., and Gary Rankin, Ph.D. <\/span>Wang<\/span> joined the School of Medicine in<\/span><\/span> 2021<\/span><\/span> and leads focused research <\/span>on understanding the physiological and pathological roles of extracellular <\/span>vesicles<\/span> (EVs) in cerebrovascular diseases such as stroke and dementia.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div>\n

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Through its Transformational Project Award, the American Heart Association supports \u201chighly innovative, high-impact projects that build on work in progress that could ultimately lead to critical discoveries or major advancements that will accelerate the field of cardiovascular and\/or cerebrovascular research.\u201d\u00a0 HUNTINGTON, W.Va. – Jinju Wang, Ph.D., assistant professor of biomedical sciences at the Marshall University […]<\/p>\n","protected":false},"author":239,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[78,79,26],"tags":[],"class_list":["post-26989","post","type-post","status-publish","format-standard","hentry","category-jcesom","category-marshall-health","category-news-releases"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.marshall.edu\/news\/wp-json\/wp\/v2\/posts\/26989","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.marshall.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.marshall.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.marshall.edu\/news\/wp-json\/wp\/v2\/users\/239"}],"replies":[{"embeddable":true,"href":"https:\/\/www.marshall.edu\/news\/wp-json\/wp\/v2\/comments?post=26989"}],"version-history":[{"count":2,"href":"https:\/\/www.marshall.edu\/news\/wp-json\/wp\/v2\/posts\/26989\/revisions"}],"predecessor-version":[{"id":26991,"href":"https:\/\/www.marshall.edu\/news\/wp-json\/wp\/v2\/posts\/26989\/revisions\/26991"}],"wp:attachment":[{"href":"https:\/\/www.marshall.edu\/news\/wp-json\/wp\/v2\/media?parent=26989"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.marshall.edu\/news\/wp-json\/wp\/v2\/categories?post=26989"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.marshall.edu\/news\/wp-json\/wp\/v2\/tags?post=26989"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}