Tragedy:
A lamentable, dreadful, or fatal event or affair; calamity; disaster.

Quote:

Every human being on this earth is born with a tragedy, and it isn’t original sin.  He’s born with the tragedy that he has to grow up.  That he has to leave the nest, the security, and go out to do battle.  He has to lose everything that is lovely and fight for a new loveliness of his own making, and it’s a tragedy.  A lot of people don’t have the courage to do it. (Helen Hayes)

Serve:
To be useful or of service to; help.

Quote:

The only ones among you who will be really happy are those who will have sought and found how to serve. (Albert Schweitzer)

Blame:
To place the responsibility for (a fault, error, etc.).

Quote:

The man who smiles when things go wrong has thought of someone to blame it on. (Robert Bloch)

Pursuit:
An effort to secure or attain; quest.

Quote:

An object in possession seldom retains the same charm that it had in pursuit. (Pliny the Younger)