Colloquium: “Determining the what, when, and how of therapeutic intervention strategies for controlling complex immune responses”

Marshall University Math Colloquium
April 14, 2015

Judy Day
University of Tennessee

Abstract
Ideally, when challenged with a bacterial insult, a host orchestrates an immune response that, not only eliminates the offending pathogen, but also restores the host to homeostasis. However, due to the complex nature of the response, this is not always possible, especially in critically ill patients. Clearly, intervention is needed; however, determining the types of intervention that should be given, when they should be given, and in what amount remains a challenge. Computational modelling and control methodologies can provide fresh insight into this challenging biomedical problem and potentially offer techniques to answer these difficult questions. This talk will discuss computational control methodologies that are being explored to determine the what, when, and how of therapeutic intervention strategies for controlling complex immune responses.