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Asking Deeper Questions

Sidney Strause’s Path from Medicine to Biomedical Discovery
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Sidney Strause stands in a lab wearing her white coat with her arms crossed
When Williamstown, West Virginia native Sidney Strause first arrived at Marshall University as a student in the accelerated BS/MD program, she imagined a future in medicine. But early in her training, a new curiosity began to take hold, one that would shift her path from clinical care to scientific discovery.

Sidney Strause wears her white coat while she looks at a bottle of liquid in a lab

Sidney earned a bachelor’s degree in biological science after three years at Marshall and is currently enrolled as a second-year Ph.D. student in the Joan C. Edwards School of Medicine (JCESOM) biomedical research program.

“I realized that research offered a vehicle to ask deeper questions.” - Sidney Strause

“I realized that research offered a vehicle to ask deeper questions—not only how diseases present clinically, but why they occur at the cellular level and how we might intervene more precisely,” Sidney said.

That realization led her into biomedical research and into a close mentorship with faculty who continue to shape her academic and professional journey.

“Mentoring graduate students such as Sidney is about turning their initial scientific curiosity into research capability,” said Sandrine Pierre, PhD, professor of biomedical sciences at JCESOM. “As they advance into the program, they gradually cease to be trainees—they become emerging colleagues who will shape the future of biomedical research.”

During her undergraduate studies, Sidney sought out hands-on research opportunities and connected with Dr. Pierre to explore cardiovascular physiology. What began as an introduction to laboratory work quickly evolved into a sustained research mentorship.

As her experience grew, so did her independence in the lab. Early on, Sidney focused on learning laboratory techniques and understanding experimental systems. Now, she is developing her own scientific questions and designing experiments to answer them.

“Mentoring graduate students such as Sidney is about turning their initial scientific curiosity into research capability.” - Dr. Pierre

“At this stage, I’m beginning to articulate my own hypotheses and think through how the tools and methods I’m learning can be applied to test them,” she said.

Sidney’s work focuses on the molecular signaling pathways that allow heart cells to produce energy efficiently and adapt to stress. In conditions like heart failure, these systems can become disrupted, leading to structural and functional changes in the heart over time. Her research examines how specific ion transport proteins and cellular signaling networks influence this remodeling process, with the goal of identifying mechanisms that could inform more targeted therapies.

In 2025, Sidney’s work earned international recognition when she received the International Union of Pure and Applied Biophysics Poster Prize at the 17th International Meeting on P-Type ATPases in Health & Disease in Cairns, Australia—placing her research among leading scientists in the field.

Sidney Strause stands in a lab smiling while wearing her white coat

Sidney was also selected for the highly competitive Porter Physiology Development Fellowship from the American Physiological Society (APS), one of the nation’s most prestigious trainee awards for graduate students in physiology. The fellowship has provided research support, structured professional development, and access to a national mentorship network, strengthening her scientific training and expanding her engagement within the physiology community.

Most recently, Sidney was awarded a prestigious American Heart Association Predoctoral Fellowship, which supports her research on cardioprotection during adverse remodeling in heart failure progression. The fellowship underscores the national significance of her work and its potential to improve understanding and treatment of heart disease.

Through these opportunities, Sidney has developed technical skills, analytical confidence, and a deeper understanding of hypothesis-driven science. They have also clarified her interest in pursuing a research-focused career where discovery, mentorship and impact intersect.

Her work has also taken her beyond Marshall’s campus, representing the university and West Virginia in international research spaces.

“Representing Marshall as a West Virginia native in international research spaces is deeply meaningful to me.” - Sidney Strause

“Representing Marshall as a West Virginia native in international research spaces is deeply meaningful to me,” Sidney said. “It demonstrates that impactful, globally relevant science can emerge from institutions rooted in regional service and community.”

Sidney credits Marshall’s collaborative research environment as a key factor in her growth. In addition to her primary mentor, she has received guidance from rotation advisors, senior scientists and instructors who invested in her development.

“Collective mentorship, paired with early responsibility and sustained access, has been central to my growth and reflects a training environment supported by a broad scientific community,” she said.

From aspiring physician to emerging biomedical researcher, Sidney’s journey reflects Marshall University’s commitment to hands-on research, close mentorship and preparing students to make meaningful contributions to science and society.

For Sidney, the work ahead remains grounded in a simple goal: keep asking deeper questions and help shape the future of biomedical research along the way.

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